GRM2 — 116 ClinVar variants
All ClinVar germline GRM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 98 flagged for review →
4 Benign · 6 Likely benign · 106 Uncertain significance
Full GRM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 98
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GRM2 p.Ala281Val Uncertain significance Single submitter
- GRM2 p.Ala287Val Uncertain significance Single submitter
- GRM2 p.Ala363Thr Uncertain significance Single submitter
- GRM2 p.Ala47Val Uncertain significance Single submitter
- GRM2 p.Ala538Thr Uncertain significance Single submitter
- GRM2 p.Ala575Thr Uncertain significance Single submitter
- GRM2 p.Ala677Thr Uncertain significance Single submitter
- GRM2 p.Ala811Val Uncertain significance Single submitter
- GRM2 p.Ala98Val Uncertain significance Single submitter
- GRM2 p.Arg247His Uncertain significance Single submitter
- GRM2 p.Arg271Cys Uncertain significance Single submitter
- GRM2 p.Arg354His Uncertain significance Single submitter
- GRM2 p.Arg358Leu Uncertain significance Single submitter
- GRM2 p.Arg405Gln Uncertain significance Single submitter
- GRM2 p.Arg445His Uncertain significance Single submitter
- GRM2 p.Arg452Cys Uncertain significance Single submitter
- GRM2 p.Arg465His Uncertain significance Single submitter
- GRM2 p.Arg467His Uncertain significance Single submitter
- GRM2 p.Arg499Cys Uncertain significance Single submitter
- GRM2 p.Arg531Gln Uncertain significance Single submitter
- GRM2 p.Arg591Gln Uncertain significance Single submitter
- GRM2 p.Arg636His Uncertain significance Single submitter
- GRM2 p.Arg665Gln Uncertain significance Single submitter
- GRM2 p.Arg713Gln Uncertain significance Single submitter
- GRM2 p.Arg720Cys Uncertain significance Single submitter
- GRM2 p.Arg724His Uncertain significance Single submitter
- GRM2 p.Arg834His Uncertain significance Single submitter
- GRM2 p.Asn722Lys Uncertain significance Single submitter
- GRM2 p.Asn73His Uncertain significance Single submitter
- GRM2 p.Cys355Tyr Uncertain significance Single submitter
- GRM2 p.Gln669Glu Uncertain significance Single submitter
- GRM2 p.Glu273Lys Uncertain significance Single submitter
- GRM2 p.Glu301Asp Uncertain significance Single submitter
- GRM2 p.Glu308Gly Uncertain significance Single submitter
- GRM2 p.Glu308Val Uncertain significance Single submitter
- GRM2 p.Gly449Asp Uncertain significance Single submitter
- GRM2 p.Gly45Ser Uncertain significance Single submitter
- GRM2 p.Gly570Glu Uncertain significance Single submitter
- GRM2 p.Gly612Ser Uncertain significance Single submitter
- GRM2 p.Gly763Val Uncertain significance Single submitter
- GRM2 p.Gly851Asp Uncertain significance Single submitter
- GRM2 p.His97Tyr Uncertain significance Single submitter
- GRM2 p.Ile136Val Uncertain significance Single submitter
- GRM2 p.Leu268Val Uncertain significance Single submitter
- GRM2 p.Leu62Met Uncertain significance Single submitter
- GRM2 p.Leu800Phe Uncertain significance Single submitter
- GRM2 p.Leu814Pro Uncertain significance Single submitter
- GRM2 p.Phe643Ser Uncertain significance Single submitter
- GRM2 p.Pro187Leu Uncertain significance Single submitter
- GRM2 p.Pro261Ala Uncertain significance Single submitter
- GRM2 p.Pro490Leu Uncertain significance Single submitter
- GRM2 p.Pro831Thr Uncertain significance Single submitter
- GRM2 p.Ser125Tyr Uncertain significance Single submitter
- GRM2 p.Ser246Gly Uncertain significance Single submitter
- GRM2 p.Ser325Arg Uncertain significance Single submitter
- GRM2 p.Ser325Thr Uncertain significance Single submitter
- GRM2 p.Ser731Leu Uncertain significance Single submitter
- GRM2 p.Thr290Ile Uncertain significance Single submitter
- GRM2 p.Thr629Met Uncertain significance Single submitter
- GRM2 p.Thr743Met Uncertain significance Single submitter
- GRM2 p.Tyr144Asp Uncertain significance Single submitter
- GRM2 p.Val17Met Uncertain significance Single submitter
- GRM2 p.Val33Met Uncertain significance Single submitter
- GRM2 p.Val588Ile Uncertain significance Single submitter
- GRM2 p.Val694Met Uncertain significance Single submitter
- GRM2 p.Val736Met Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- GRM2 p.Ala127Glu Uncertain significance Single submitter
- GRM2 p.Arg200His Uncertain significance Single submitter
- GRM2 p.Arg346His Uncertain significance Single submitter
- GRM2 p.Arg354Cys Uncertain significance Single submitter
- GRM2 p.Arg358Trp Uncertain significance Single submitter
- GRM2 p.Arg397Cys Uncertain significance Single submitter
- GRM2 p.Arg562Cys Uncertain significance Single submitter
- GRM2 p.Arg635Gln Uncertain significance Single submitter
- GRM2 p.Arg788Gln Uncertain significance Single submitter
- GRM2 p.Arg829Gln Uncertain significance Single submitter
- GRM2 p.Arg829Trp Uncertain significance Single submitter
- GRM2 p.Asn203Ser Uncertain significance Single submitter
- GRM2 p.Asn286Ser Uncertain significance Single submitter
- GRM2 p.Asp215Asn Uncertain significance Single submitter
- GRM2 p.Asp866Gly Uncertain significance Single submitter
- GRM2 p.Cys576Ser Uncertain significance Single submitter
- GRM2 p.Cys859Arg Uncertain significance Single submitter
- GRM2 p.Gln669Pro Uncertain significance Single submitter
- GRM2 p.Gln820His Uncertain significance Single submitter
- GRM2 p.Glu197Gln Uncertain significance Single submitter
- GRM2 p.Glu604Asp Uncertain significance Single submitter
- GRM2 p.Gly44Ser Uncertain significance Single submitter
- GRM2 p.Leu480Val Uncertain significance Single submitter
- GRM2 p.Phe105Leu Uncertain significance Single submitter
- GRM2 p.Phe201Leu Uncertain significance Single submitter
- GRM2 p.Phe535Ser Uncertain significance Single submitter
- GRM2 p.Pro514Leu Uncertain significance Single submitter
- GRM2 p.Pro711Leu Uncertain significance Single submitter
- GRM2 p.Ser356Gly Uncertain significance Single submitter
- GRM2 p.Thr620Asn Uncertain significance Single submitter
- GRM2 p.Val382Ala Uncertain significance Single submitter
- GRM2 p.Val796Ala Uncertain significance Single submitter
All GRM2 variants
Benign 4
- p.Asn824= Multiple submitters
- p.Asn439Ser Single submitter
- p.Thr270= Single submitter
- p.Val865= Single submitter
Likely benign 6
- p.Ala248Val Single submitter
- p.Asp123= Single submitter
- p.Gly296= Single submitter
- p.Gly667= Single submitter
- p.Ile140= Single submitter
- p.Leu692Phe Single submitter
Uncertain significance 106
- p.Ala127Glu Single submitter ⚠
- p.Ala275Val Single submitter
- p.Ala281Val Single submitter ⚠
- p.Ala287Val Single submitter ⚠
- p.Ala363Thr Single submitter ⚠
- p.Ala430Val Single submitter
- p.Ala47Val Single submitter ⚠
- p.Ala538Thr Single submitter ⚠
- p.Ala575Thr Single submitter ⚠
- p.Ala677Thr Single submitter ⚠
- p.Ala811Val Single submitter ⚠
- p.Ala98Val Single submitter ⚠
- p.Arg200His Single submitter ⚠
- p.Arg247His Single submitter ⚠
- p.Arg271Cys Single submitter ⚠
- p.Arg346His Single submitter ⚠
- p.Arg354Cys Single submitter ⚠
- p.Arg354His Single submitter ⚠
- p.Arg358Leu Single submitter ⚠
- p.Arg358Trp Single submitter ⚠
- p.Arg397Cys Single submitter ⚠
- p.Arg405Gln Single submitter ⚠
- p.Arg445His Single submitter ⚠
- p.Arg452Cys Single submitter ⚠
- p.Arg465Cys Single submitter
- p.Arg465His Single submitter ⚠
- p.Arg467Cys Single submitter
- p.Arg467His Single submitter ⚠
- p.Arg499Cys Single submitter ⚠
- p.Arg531Gln Single submitter ⚠
- p.Arg562Cys Single submitter ⚠
- p.Arg591Gln Single submitter ⚠
- p.Arg635Gln Single submitter ⚠
- p.Arg636His Single submitter ⚠
- p.Arg665Gln Single submitter ⚠
- p.Arg713Gln Single submitter ⚠
- p.Arg714Gln Single submitter
- p.Arg720Cys Single submitter ⚠
- p.Arg724His Single submitter ⚠
- p.Arg788Gln Single submitter ⚠
- p.Arg829Gln Single submitter ⚠
- p.Arg829Trp Single submitter ⚠
- p.Arg834His Single submitter ⚠
- p.Asn203Ser Single submitter ⚠
- p.Asn286Ser Single submitter ⚠
- p.Asn722Lys Single submitter ⚠
- p.Asn73His Single submitter ⚠
- p.Asp215Asn Single submitter ⚠
- p.Asp866Gly Single submitter ⚠
- p.Cys355Tyr Single submitter ⚠
- p.Cys576Ser Single submitter ⚠
- p.Cys859Arg Single submitter ⚠
- p.Gln669Glu Single submitter ⚠
- p.Gln669Pro Single submitter ⚠
- p.Gln820His Single submitter ⚠
- p.Glu197Gln Single submitter ⚠
- p.Glu273Lys Single submitter ⚠
- p.Glu301Asp Single submitter ⚠
- p.Glu308Gly Single submitter ⚠
- p.Glu308Val Single submitter ⚠
- p.Glu604Asp Single submitter ⚠
- p.Gly449Asp Single submitter ⚠
- p.Gly44Ser Single submitter ⚠
- p.Gly45Ser Single submitter ⚠
- p.Gly570Glu Single submitter ⚠
- p.Gly612Ser Single submitter ⚠
- p.Gly704Asp Single submitter
- p.Gly763Val Single submitter ⚠
- p.Gly851Asp Single submitter ⚠
- p.His97Tyr Single submitter ⚠
- p.Ile136Val Single submitter ⚠
- p.Leu268Val Single submitter ⚠
- p.Leu480Val Single submitter ⚠
- p.Leu62Met Single submitter ⚠
- p.Leu800Phe Single submitter ⚠
- p.Leu814Pro Single submitter ⚠
- p.Phe105Leu Single submitter ⚠
- p.Phe201Leu Single submitter ⚠
- p.Phe535Ser Single submitter ⚠
- p.Phe643Ser Single submitter ⚠
- p.Pro187Leu Single submitter ⚠
- p.Pro261Ala Single submitter ⚠
- p.Pro490Leu Single submitter ⚠
- p.Pro514Leu Single submitter ⚠
- p.Pro711Leu Single submitter ⚠
- p.Pro831Thr Single submitter ⚠
- p.Ser125Tyr Single submitter ⚠
- p.Ser246Gly Single submitter ⚠
- p.Ser325Arg Single submitter ⚠
- p.Ser325Thr Single submitter ⚠
- p.Ser356Gly Single submitter ⚠
- p.Ser731Leu Single submitter ⚠
- p.Ser870Leu Single submitter
- p.Thr290Ile Single submitter ⚠
- p.Thr620Asn Single submitter ⚠
- p.Thr629Met Single submitter ⚠
- p.Thr743Met Single submitter ⚠
- p.Tyr144Asp Single submitter ⚠
- p.Val17Met Single submitter ⚠
- p.Val33Met Single submitter ⚠
- p.Val382Ala Single submitter ⚠
- p.Val588Ile Single submitter ⚠
- p.Val694Leu Single submitter
- p.Val694Met Single submitter ⚠
- p.Val736Met Single submitter ⚠
- p.Val796Ala Single submitter ⚠