GRM4 — 136 ClinVar variants
All ClinVar germline GRM4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 117 flagged for review →
8 Benign · 3 Likely benign · 125 Uncertain significance
Full GRM4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 117
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 94
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GRM4 p.Ala251Thr Uncertain significance Single submitter
- GRM4 p.Ala399Thr Uncertain significance Single submitter
- GRM4 p.Ala422Thr Uncertain significance Single submitter
- GRM4 p.Ala701Thr Uncertain significance Single submitter
- GRM4 p.Ala81Thr Uncertain significance Single submitter
- GRM4 p.Ala862Val Uncertain significance Single submitter
- GRM4 p.Ala885Thr Uncertain significance Single submitter
- GRM4 p.Ala895Val Uncertain significance Single submitter
- GRM4 p.Ala897Val Uncertain significance Single submitter
- GRM4 p.Arg104Cys Uncertain significance Single submitter
- GRM4 p.Arg135His Uncertain significance Single submitter
- GRM4 p.Arg13Gln Uncertain significance Single submitter
- GRM4 p.Arg170Cys Uncertain significance Single submitter
- GRM4 p.Arg170His Uncertain significance Single submitter
- GRM4 p.Arg258Trp Uncertain significance Single submitter
- GRM4 p.Arg270Leu Uncertain significance Single submitter
- GRM4 p.Arg391His Uncertain significance Single submitter
- GRM4 p.Arg505Gln Uncertain significance Single submitter
- GRM4 p.Arg517Cys Uncertain significance Single submitter
- GRM4 p.Arg517His Uncertain significance Single submitter
- GRM4 p.Arg570His Uncertain significance Single submitter
- GRM4 p.Arg60Gln Uncertain significance Single submitter
- GRM4 p.Arg623His Uncertain significance Single submitter
- GRM4 p.Arg676His Uncertain significance Single submitter
- GRM4 p.Arg686His Uncertain significance Single submitter
- GRM4 p.Arg775His Uncertain significance Single submitter
- GRM4 p.Arg78Trp Uncertain significance Single submitter
- GRM4 p.Arg858His Uncertain significance Single submitter
- GRM4 p.Asn569Ser Uncertain significance Single submitter
- GRM4 p.Asn613Lys Uncertain significance Single submitter
- GRM4 p.Asn782Ser Uncertain significance Single submitter
- GRM4 p.Asn852Lys Uncertain significance Single submitter
- GRM4 p.Asn91His Uncertain significance Single submitter
- GRM4 p.Asp345Asn Uncertain significance Single submitter
- GRM4 p.Asp439Glu Uncertain significance Single submitter
- GRM4 p.Asp614Asn Uncertain significance Single submitter
- GRM4 p.Asp648Asn Uncertain significance Single submitter
- GRM4 p.Gln481Lys Uncertain significance Single submitter
- GRM4 p.Gln513Pro Uncertain significance Single submitter
- GRM4 p.Glu117Lys Uncertain significance Single submitter
- GRM4 p.Glu232Asp Uncertain significance Single submitter
- GRM4 p.Glu236Asp Uncertain significance Single submitter
- GRM4 p.Glu274Gly Uncertain significance Single submitter
- GRM4 p.Glu543Lys Uncertain significance Single submitter
- GRM4 p.Glu891Gln Uncertain significance Single submitter
- GRM4 p.Gly137Ser Uncertain significance Single submitter
- GRM4 p.Gly140Asp Uncertain significance Single submitter
- GRM4 p.Gly228Asp Uncertain significance Single submitter
- GRM4 p.Gly246Val Uncertain significance Single submitter
- GRM4 p.Gly473Glu Uncertain significance Single submitter
- GRM4 p.Gly684Asp Uncertain significance Single submitter
- GRM4 p.Gly68Val Uncertain significance Single submitter
- GRM4 p.His323Tyr Uncertain significance Single submitter
- GRM4 p.His39Tyr Uncertain significance Single submitter
- GRM4 p.Ile212Val Uncertain significance Single submitter
- GRM4 p.Ile410Met Uncertain significance Single submitter
- GRM4 p.Ile644Thr Uncertain significance Single submitter
- GRM4 p.Ile99Val Uncertain significance Single submitter
- GRM4 p.Leu31Val Uncertain significance Single submitter
- GRM4 p.Leu592Arg Uncertain significance Single submitter
- GRM4 p.Leu654Pro Uncertain significance Single submitter
- GRM4 p.Leu706Phe Uncertain significance Single submitter
- GRM4 p.Leu893Pro Uncertain significance Single submitter
- GRM4 p.Lys673Thr Uncertain significance Single submitter
- GRM4 p.Lys814Met Uncertain significance Single submitter
- GRM4 p.Met164Ile Uncertain significance Single submitter
- GRM4 p.Met27Ile Uncertain significance Single submitter
- GRM4 p.Met836Ile Uncertain significance Single submitter
- GRM4 p.Phe408Ser Uncertain significance Single submitter
- GRM4 p.Pro25His Uncertain significance Single submitter
- GRM4 p.Pro34Ser Uncertain significance Single submitter
- GRM4 p.Pro38Ala Uncertain significance Single submitter
- GRM4 p.Pro38Leu Uncertain significance Single submitter
- GRM4 p.Pro526Ala Uncertain significance Single submitter
- GRM4 p.Pro577Leu Uncertain significance Single submitter
- GRM4 p.Pro696Ser Uncertain significance Single submitter
- GRM4 p.Ser383Asn Uncertain significance Single submitter
- GRM4 p.Ser752Leu Uncertain significance Single submitter
- GRM4 p.Thr275Ala Uncertain significance Single submitter
- GRM4 p.Thr303Ile Uncertain significance Single submitter
- GRM4 p.Thr615Met Uncertain significance Single submitter
- GRM4 p.Thr808Pro Uncertain significance Single submitter
- GRM4 p.Thr819Met Uncertain significance Single submitter
- GRM4 p.Thr908Ile Uncertain significance Single submitter
- GRM4 p.Thr908Ser Uncertain significance Single submitter
- GRM4 p.Trp10Leu Uncertain significance Single submitter
- GRM4 p.Trp9Cys Uncertain significance Single submitter
- GRM4 p.Tyr230Cys Uncertain significance Single submitter
- GRM4 p.Val198Leu Uncertain significance Single submitter
- GRM4 p.Val432Met Uncertain significance Single submitter
- GRM4 p.Val453Ile Uncertain significance Single submitter
- GRM4 p.Val596Met Uncertain significance Single submitter
- GRM4 p.Val777Leu Uncertain significance Single submitter
- GRM4 p.Val905Ile Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- GRM4 p.Ala278Thr Uncertain significance Single submitter
- GRM4 p.Arg292Cys Uncertain significance Single submitter
- GRM4 p.Arg425Cys Uncertain significance Single submitter
- GRM4 p.Arg483Cys Benign Single submitter
- GRM4 p.Arg554Cys Uncertain significance Single submitter
- GRM4 p.Arg611Cys Uncertain significance Single submitter
- GRM4 p.Arg611His Uncertain significance Single submitter
- GRM4 p.Asn466Ser Uncertain significance Single submitter
- GRM4 p.Asp411Asn Uncertain significance Single submitter
- GRM4 p.Gln207Arg Uncertain significance Single submitter
- GRM4 p.Gln810Arg Uncertain significance Single submitter
- GRM4 p.Glu488Lys Uncertain significance Single submitter
- GRM4 p.Gly547Glu Uncertain significance Single submitter
- GRM4 p.His305Tyr Uncertain significance Single submitter
- GRM4 p.Leu18Pro Uncertain significance Single submitter
- GRM4 p.Lys673Glu Uncertain significance Single submitter
- GRM4 p.Ser253Leu Uncertain significance Single submitter
- GRM4 p.Thr203Met Uncertain significance Single submitter
- GRM4 p.Thr571Met Uncertain significance Single submitter
- GRM4 p.Thr734Ile Uncertain significance Single submitter
- GRM4 p.Thr820Met Uncertain significance Single submitter
- GRM4 p.Val248Met Uncertain significance Single submitter
- GRM4 p.Val606Gly Uncertain significance Single submitter
All GRM4 variants
Benign 8
Likely benign 3
- c.520-10C>T Single submitter
- p.Pro647= Single submitter
- p.Tyr23= Single submitter
Uncertain significance 125
- p.Ala251Thr Single submitter ⚠
- p.Ala278Thr Single submitter ⚠
- p.Ala399Thr Single submitter ⚠
- p.Ala422Thr Single submitter ⚠
- p.Ala701Thr Single submitter ⚠
- p.Ala81Thr Single submitter ⚠
- p.Ala862Val Single submitter ⚠
- p.Ala885Thr Single submitter ⚠
- p.Ala895Val Single submitter ⚠
- p.Ala897Val Single submitter ⚠
- p.Arg104Cys Single submitter ⚠
- p.Arg135Cys Single submitter
- p.Arg135His Single submitter ⚠
- p.Arg13Gln Single submitter ⚠
- p.Arg170Cys Single submitter ⚠
- p.Arg170His Single submitter ⚠
- p.Arg258Trp Single submitter ⚠
- p.Arg270Leu Single submitter ⚠
- p.Arg292Cys Single submitter ⚠
- p.Arg391His Single submitter ⚠
- p.Arg425Cys Single submitter ⚠
- p.Arg437Cys Single submitter
- p.Arg505Gln Single submitter ⚠
- p.Arg517Cys Single submitter ⚠
- p.Arg517His Single submitter ⚠
- p.Arg554Cys Single submitter ⚠
- p.Arg570His Single submitter ⚠
- p.Arg60Gln Single submitter ⚠
- p.Arg60Trp Single submitter
- p.Arg611Cys Single submitter ⚠
- p.Arg611His Single submitter ⚠
- p.Arg623His Single submitter ⚠
- p.Arg676His Single submitter ⚠
- p.Arg686His Single submitter ⚠
- p.Arg775His Single submitter ⚠
- p.Arg78Trp Single submitter ⚠
- p.Arg856Cys Single submitter
- p.Arg858His Single submitter ⚠
- p.Arg88Leu Single submitter
- p.Asn466Ser Single submitter ⚠
- p.Asn569Ser Single submitter ⚠
- p.Asn613Lys Single submitter ⚠
- p.Asn782Ser Single submitter ⚠
- p.Asn852Lys Single submitter ⚠
- p.Asn91His Single submitter ⚠
- p.Asp345Asn Single submitter ⚠
- p.Asp411Asn Single submitter ⚠
- p.Asp439Glu Single submitter ⚠
- p.Asp614Asn Single submitter ⚠
- p.Asp648Asn Single submitter ⚠
- p.Asp728fs Single submitter
- p.Gln207Arg Single submitter ⚠
- p.Gln481Lys Single submitter ⚠
- p.Gln513Pro Single submitter ⚠
- p.Gln810Arg Single submitter ⚠
- p.Glu117Lys Single submitter ⚠
- p.Glu232Asp Single submitter ⚠
- p.Glu236Asp Single submitter ⚠
- p.Glu274Gly Single submitter ⚠
- p.Glu488Lys Single submitter ⚠
- p.Glu543Lys Single submitter ⚠
- p.Glu891Gln Single submitter ⚠
- p.Gly137Ser Single submitter ⚠
- p.Gly140Asp Single submitter ⚠
- p.Gly228Asp Single submitter ⚠
- p.Gly246Val Single submitter ⚠
- p.Gly473Glu Single submitter ⚠
- p.Gly547Glu Single submitter ⚠
- p.Gly684Asp Single submitter ⚠
- p.Gly68Val Single submitter ⚠
- p.His305Tyr Single submitter ⚠
- p.His323Tyr Single submitter ⚠
- p.His39Tyr Single submitter ⚠
- p.Ile212Val Single submitter ⚠
- p.Ile410Met Single submitter ⚠
- p.Ile644Thr Single submitter ⚠
- p.Ile99Val Single submitter ⚠
- p.Leu18Pro Single submitter ⚠
- p.Leu31Val Single submitter ⚠
- p.Leu592Arg Single submitter ⚠
- p.Leu654Pro Single submitter ⚠
- p.Leu706Phe Single submitter ⚠
- p.Leu893Pro Single submitter ⚠
- p.Lys673Glu Single submitter ⚠
- p.Lys673Thr Single submitter ⚠
- p.Lys814Met Single submitter ⚠
- p.Met164Ile Single submitter ⚠
- p.Met1Ile Single submitter
- p.Met27Ile Single submitter ⚠
- p.Met836Ile Single submitter ⚠
- p.Met836Val Single submitter
- p.Phe408Ser Single submitter ⚠
- p.Pro25His Single submitter ⚠
- p.Pro34Ser Single submitter ⚠
- p.Pro38Ala Single submitter ⚠
- p.Pro38Leu Single submitter ⚠
- p.Pro526Ala Single submitter ⚠
- p.Pro577Leu Single submitter ⚠
- p.Pro696Ser Single submitter ⚠
- p.Ser253Leu Single submitter ⚠
- p.Ser383Asn Single submitter ⚠
- p.Ser752Leu Single submitter ⚠
- p.Thr203Met Single submitter ⚠
- p.Thr275Ala Single submitter ⚠
- p.Thr303Ile Single submitter ⚠
- p.Thr571Met Single submitter ⚠
- p.Thr615Met Single submitter ⚠
- p.Thr734Ile Single submitter ⚠
- p.Thr808Pro Single submitter ⚠
- p.Thr819Met Single submitter ⚠
- p.Thr820Met Single submitter ⚠
- p.Thr908Ile Single submitter ⚠
- p.Thr908Ser Single submitter ⚠
- p.Trp10Leu Single submitter ⚠
- p.Trp14Ter Single submitter
- p.Trp9Cys Single submitter ⚠
- p.Tyr230Cys Single submitter ⚠
- p.Val198Leu Single submitter ⚠
- p.Val248Met Single submitter ⚠
- p.Val432Met Single submitter ⚠
- p.Val453Ile Single submitter ⚠
- p.Val596Met Single submitter ⚠
- p.Val606Gly Single submitter ⚠
- p.Val777Leu Single submitter ⚠
- p.Val905Ile Single submitter ⚠