GRM8 — 145 ClinVar variants
All ClinVar germline GRM8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
1 Conflicting · 14 Benign · 22 Likely benign · 108 Uncertain significance
Full GRM8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 82
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GRM8 p.Ala180Ser Uncertain significance Single submitter
- GRM8 p.Ala9Gly Uncertain significance Single submitter
- GRM8 p.Arg258Lys Uncertain significance Single submitter
- GRM8 p.Arg289Lys Uncertain significance Single submitter
- GRM8 p.Arg447Trp Uncertain significance Single submitter
- GRM8 p.Arg470Cys Uncertain significance Single submitter
- GRM8 p.Arg540His Uncertain significance Single submitter
- GRM8 p.Arg566His Uncertain significance Single submitter
- GRM8 p.Arg651Gln Uncertain significance Single submitter
- GRM8 p.Arg652Gln Uncertain significance Single submitter
- GRM8 p.Arg7Gln Uncertain significance Single submitter
- GRM8 p.Arg7Leu Uncertain significance Single submitter
- GRM8 p.Arg852Leu Uncertain significance Single submitter
- GRM8 p.Asn135Tyr Uncertain significance Single submitter
- GRM8 p.Asn353Asp Uncertain significance Single submitter
- GRM8 p.Asn545Lys Uncertain significance Single submitter
- GRM8 p.Asp104Asn Uncertain significance Single submitter
- GRM8 p.Gln115Lys Uncertain significance Single submitter
- GRM8 p.Gln249His Uncertain significance Single submitter
- GRM8 p.Gln320Leu Uncertain significance Single submitter
- GRM8 p.Gly136Arg Uncertain significance Single submitter
- GRM8 p.Gly149Cys Uncertain significance Single submitter
- GRM8 p.Gly400Arg Uncertain significance Single submitter
- GRM8 p.Gly439Arg Uncertain significance Single submitter
- GRM8 p.Gly465Arg Uncertain significance Single submitter
- GRM8 p.Gly465Val Uncertain significance Single submitter
- GRM8 p.Gly523Glu Uncertain significance Single submitter
- GRM8 p.Gly543Asp Uncertain significance Single submitter
- GRM8 p.Gly618Arg Uncertain significance Single submitter
- GRM8 p.Gly61Glu Uncertain significance Single submitter
- GRM8 p.His490Arg Uncertain significance Single submitter
- GRM8 p.His511Tyr Uncertain significance Single submitter
- GRM8 p.His720Tyr Uncertain significance Single submitter
- GRM8 p.Ile209Leu Uncertain significance Single submitter
- GRM8 p.Ile381Val Uncertain significance Single submitter
- GRM8 p.Ile437Leu Uncertain significance Single submitter
- GRM8 p.Ile613Met Uncertain significance Single submitter
- GRM8 p.Ile635Val Uncertain significance Single submitter
- GRM8 p.Ile640Val Uncertain significance Single submitter
- GRM8 p.Ile721Met Uncertain significance Single submitter
- GRM8 p.Ile841Val Uncertain significance Single submitter
- GRM8 p.Leu117Val Uncertain significance Single submitter
- GRM8 p.Leu25Val Uncertain significance Single submitter
- GRM8 p.Leu442Pro Uncertain significance Single submitter
- GRM8 p.Leu818Ile Uncertain significance Single submitter
- GRM8 p.Leu93Ile Uncertain significance Single submitter
- GRM8 p.Lys252Thr Uncertain significance Single submitter
- GRM8 p.Lys481Arg Uncertain significance Single submitter
- GRM8 p.Lys486Arg Uncertain significance Single submitter
- GRM8 p.Met161Thr Uncertain significance Single submitter
- GRM8 p.Met27Val Uncertain significance Single submitter
- GRM8 p.Met419Val Uncertain significance Single submitter
- GRM8 p.Met564Val Uncertain significance Single submitter
- GRM8 p.Met639Val Uncertain significance Single submitter
- GRM8 p.Met811Arg Uncertain significance Single submitter
- GRM8 p.Met832Val Uncertain significance Single submitter
- GRM8 p.Pro317Leu Uncertain significance Single submitter
- GRM8 p.Pro432Gln Uncertain significance Single submitter
- GRM8 p.Pro612Ser Uncertain significance Single submitter
- GRM8 p.Ser219Leu Uncertain significance Single submitter
- GRM8 p.Ser300Asn Uncertain significance Single submitter
- GRM8 p.Ser300Thr Uncertain significance Single submitter
- GRM8 p.Ser411Thr Uncertain significance Single submitter
- GRM8 p.Thr110Ile Uncertain significance Single submitter
- GRM8 p.Thr18Asn Uncertain significance Single submitter
- GRM8 p.Thr599Ile Uncertain significance Single submitter
- GRM8 p.Thr627Met Uncertain significance Single submitter
- GRM8 p.Thr670Arg Uncertain significance Single submitter
- GRM8 p.Thr764Ala Uncertain significance Single submitter
- GRM8 p.Thr770Met Uncertain significance Single submitter
- GRM8 p.Thr815Lys Uncertain significance Single submitter
- GRM8 p.Trp504Arg Uncertain significance Single submitter
- GRM8 p.Tyr22Cys Uncertain significance Single submitter
- GRM8 p.Tyr766His Uncertain significance Single submitter
- GRM8 p.Val120Met Uncertain significance Single submitter
- GRM8 p.Val158Met Uncertain significance Single submitter
- GRM8 p.Val603Leu Uncertain significance Single submitter
- GRM8 p.Val624Met Uncertain significance Single submitter
- GRM8 p.Val62Leu Uncertain significance Single submitter
- GRM8 p.Val705Leu Uncertain significance Single submitter
-
GRM8 p.Arg852Cys
Uncertain significance
No assertion criteria
prostate cancer
- GRM8 p.Pro687Ser Uncertain significance No assertion criteria
Predictors split 21
The independent predictors disagree with each other — read with care.
- GRM8 p.Pro512Ala Benign Multiple submitters
- GRM8 p.Arg525Gly Uncertain significance Single submitter
- GRM8 p.Arg540Cys Uncertain significance Single submitter
- GRM8 p.Arg607Cys Uncertain significance Single submitter
- GRM8 p.Glu326Asp Uncertain significance Single submitter
- GRM8 p.Glu326Lys Uncertain significance Single submitter
- GRM8 p.Gly214Arg Uncertain significance Single submitter
- GRM8 p.Gly726Arg Uncertain significance Single submitter
- GRM8 p.His302Arg Likely benign Single submitter
- GRM8 p.Leu758Phe Uncertain significance Single submitter
- GRM8 p.Lys401Arg Uncertain significance Single submitter
- GRM8 p.Lys681Arg Uncertain significance Single submitter
- GRM8 p.Lys837Arg Uncertain significance Single submitter
- GRM8 p.Phe605Leu Uncertain significance Single submitter
- GRM8 p.Pro425His Uncertain significance Single submitter
- GRM8 p.Pro519Leu Uncertain significance Single submitter
- GRM8 p.Pro582Ser Uncertain significance Single submitter
- GRM8 p.Ser683Cys Uncertain significance Single submitter
- GRM8 p.Thr770Ala Uncertain significance Single submitter
- GRM8 p.Thr816Ala Uncertain significance Single submitter
- GRM8 p.Tyr319Cys Uncertain significance Single submitter
All GRM8 variants
Conflicting classifications of pathogenicity 1
- p.Ala513Val Single submitter ⚠
Benign 14
- c.1495-9T>C Multiple submitters
- p.Arg561= Multiple submitters
- p.Gly231= Multiple submitters
- p.His32Gln Multiple submitters
- p.Ile265Thr Multiple submitters
- p.Ile488= Multiple submitters
- p.Phe119= Multiple submitters
- p.Phe21Cys Multiple submitters
- p.Pro512Ala Multiple submitters ⚠
- p.Ser10Cys Multiple submitters
- p.Ala665= Single submitter
- p.Val739= Single submitter
- c.1157-3C>A No assertion criteria GRM8-related disorder
- c.2431-10dup No assertion criteria GRM8-related disorder
Likely benign 22
- c.1494+10G>A Single submitter
- c.1495-10A>G Single submitter
- p.Ala282= Single submitter
- p.Ala513= Single submitter
- p.Ala686= Single submitter
- p.Arg258= Single submitter
- p.Arg729= Single submitter
- p.His302Arg Single submitter ⚠
- p.Leu555Arg Single submitter
- p.Leu558= Single submitter
- p.Lys735= Single submitter
- p.Lys872Arg Single submitter
- p.Ser129= Single submitter
- p.Ser157= Single submitter
- p.Ser219= Single submitter
- p.Thr611= Single submitter
- p.Tyr396= Single submitter
- p.Val195= Single submitter
- p.Val705Ile Single submitter
- p.Leu626= No assertion criteria GRM8-related disorder
- p.Pro719= No assertion criteria GRM8-related disorder
- p.Thr528= No assertion criteria GRM8-related disorder
Uncertain significance 108
- c.2677+18T>C Single submitter
- p.Ala180Ser Single submitter ⚠
- p.Ala9Gly Single submitter ⚠
- p.Arg258Lys Single submitter ⚠
- p.Arg289Lys Single submitter ⚠
- p.Arg447Trp Single submitter ⚠
- p.Arg470Cys Single submitter ⚠
- p.Arg525Gly Single submitter ⚠
- p.Arg540Cys Single submitter ⚠
- p.Arg540His Single submitter ⚠
- p.Arg566His Single submitter ⚠
- p.Arg607Cys Single submitter ⚠
- p.Arg651Gln Single submitter ⚠
- p.Arg652Gln Single submitter ⚠
- p.Arg7Gln Single submitter ⚠
- p.Arg7Leu Single submitter ⚠
- p.Arg852His Single submitter
- p.Arg852Leu Single submitter ⚠
- p.Asn135Tyr Single submitter ⚠
- p.Asn353Asp Single submitter ⚠
- p.Asn545Lys Single submitter ⚠
- p.Asp104Asn Single submitter ⚠
- p.Asp130Glu Single submitter
- p.Asp145Asn Single submitter
- p.Gln115Lys Single submitter ⚠
- p.Gln249His Single submitter ⚠
- p.Gln320Leu Single submitter ⚠
- p.Glu326Asp Single submitter ⚠
- p.Glu326Lys Single submitter ⚠
- p.Gly136Arg Single submitter ⚠
- p.Gly149Cys Single submitter ⚠
- p.Gly214Arg Single submitter ⚠
- p.Gly400Arg Single submitter ⚠
- p.Gly439Arg Single submitter ⚠
- p.Gly465Arg Single submitter ⚠
- p.Gly465Val Single submitter ⚠
- p.Gly523Glu Single submitter ⚠
- p.Gly543Asp Single submitter ⚠
- p.Gly618Arg Single submitter ⚠
- p.Gly61Glu Single submitter ⚠
- p.Gly726Arg Single submitter ⚠
- p.His490Arg Single submitter ⚠
- p.His511Tyr Single submitter ⚠
- p.His720Tyr Single submitter ⚠
- p.Ile165Val Single submitter
- p.Ile209Leu Single submitter ⚠
- p.Ile381Val Single submitter ⚠
- p.Ile437Leu Single submitter ⚠
- p.Ile613Met Single submitter ⚠
- p.Ile635Val Single submitter ⚠
- p.Ile640Val Single submitter ⚠
- p.Ile721Met Single submitter ⚠
- p.Ile841Val Single submitter ⚠
- p.Leu117Val Single submitter ⚠
- p.Leu25Val Single submitter ⚠
- p.Leu442Pro Single submitter ⚠
- p.Leu758Phe Single submitter ⚠
- p.Leu818Ile Single submitter ⚠
- p.Leu93Ile Single submitter ⚠
- p.Lys252Thr Single submitter ⚠
- p.Lys401Arg Single submitter ⚠
- p.Lys481Arg Single submitter ⚠
- p.Lys486Arg Single submitter ⚠
- p.Lys681Arg Single submitter ⚠
- p.Lys837Arg Single submitter ⚠
- p.Met161Thr Single submitter ⚠
- p.Met27Val Single submitter ⚠
- p.Met280Thr Single submitter
- p.Met419Val Single submitter ⚠
- p.Met564Val Single submitter ⚠
- p.Met639Val Single submitter ⚠
- p.Met811Arg Single submitter ⚠
- p.Met832Val Single submitter ⚠
- p.Phe605Leu Single submitter ⚠
- p.Pro317Leu Single submitter ⚠
- p.Pro425His Single submitter ⚠
- p.Pro432Gln Single submitter ⚠
- p.Pro519Leu Single submitter ⚠
- p.Pro582Ser Single submitter ⚠
- p.Pro612Ser Single submitter ⚠
- p.Ser219Leu Single submitter ⚠
- p.Ser300Asn Single submitter ⚠
- p.Ser300Thr Single submitter ⚠
- p.Ser411Thr Single submitter ⚠
- p.Ser683Cys Single submitter ⚠
- p.Thr110Ile Single submitter ⚠
- p.Thr18Asn Single submitter ⚠
- p.Thr599Ile Single submitter ⚠
- p.Thr627Met Single submitter ⚠
- p.Thr670Arg Single submitter ⚠
- p.Thr764Ala Single submitter ⚠
- p.Thr770Ala Single submitter ⚠
- p.Thr770Met Single submitter ⚠
- p.Thr815Lys Single submitter ⚠
- p.Thr816Ala Single submitter ⚠
- p.Trp504Arg Single submitter ⚠
- p.Tyr22Cys Single submitter ⚠
- p.Tyr319Cys Single submitter ⚠
- p.Tyr766His Single submitter ⚠
- p.Val120Met Single submitter ⚠
- p.Val158Met Single submitter ⚠
- p.Val603Leu Single submitter ⚠
- p.Val624Met Single submitter ⚠
- p.Val62Leu Single submitter ⚠
- p.Val705Leu Single submitter ⚠
- p.Arg348Ter No assertion criteria
- p.Arg852Cys No assertion criteria prostate cancer ⚠
- p.Pro687Ser No assertion criteria ⚠