GRPR — 47 ClinVar variants
All ClinVar germline GRPR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
3 Benign · 10 Likely benign · 34 Uncertain significance
Full GRPR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GRPR p.Ala136Val Uncertain significance Single submitter
- GRPR p.Ala369Val Uncertain significance Single submitter
- GRPR p.Arg144Trp Uncertain significance Single submitter
- GRPR p.Arg261Gln Uncertain significance Single submitter
- GRPR p.Arg347Gln Uncertain significance Single submitter
- GRPR p.Arg347Trp Uncertain significance Single submitter
- GRPR p.Arg72Gln Uncertain significance Single submitter
- GRPR p.Asp27Asn Uncertain significance Single submitter
- GRPR p.Glu381Lys Uncertain significance Single submitter
- GRPR p.Gly125Glu Uncertain significance Single submitter
- GRPR p.Gly343Asp Uncertain significance Single submitter
- GRPR p.Ile119Val Uncertain significance Single submitter
- GRPR p.Ile157Met Uncertain significance Single submitter
- GRPR p.Ile209Met Uncertain significance Single submitter
- GRPR p.Ile250Val Uncertain significance Single submitter
- GRPR p.Ile378Asn Uncertain significance Single submitter
- GRPR p.Leu28Phe Uncertain significance Single submitter
- GRPR p.Leu84Phe Uncertain significance Single submitter
- GRPR p.Leu87Val Uncertain significance Single submitter
- GRPR p.Pro75Leu Uncertain significance Single submitter
- GRPR p.Ser224Leu Uncertain significance Single submitter
- GRPR p.Ser363Arg Uncertain significance Single submitter
- GRPR p.Thr351Ile Uncertain significance Single submitter
- GRPR p.Thr356Ile Uncertain significance Single submitter
- GRPR p.Thr370Ile Uncertain significance Single submitter
- GRPR p.Thr67Arg Uncertain significance Single submitter
- GRPR p.Val177Met Uncertain significance Single submitter
- GRPR p.Val246Met Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All GRPR variants
Likely benign 10
- p.Lys362= Multiple submitters
- p.Val220Ile Multiple submitters
- p.Cys6Ser Single submitter
- p.His380= Single submitter
- p.Ile91Val Single submitter
- p.Phe301= Single submitter
- p.Ser168= Single submitter
- p.Val384= Single submitter
- p.Leu262Val No assertion criteria GRPR-related disorder
- p.Pro37Leu No assertion criteria GRPR-related disorder
Uncertain significance 34
- p.Ala136Val Single submitter ⚠
- p.Ala369Val Single submitter ⚠
- p.Arg144Trp Single submitter ⚠
- p.Arg261Gln Single submitter ⚠
- p.Arg287Leu Single submitter ⚠
- p.Arg347Gln Single submitter ⚠
- p.Arg347Trp Single submitter ⚠
- p.Arg72Gln Single submitter ⚠
- p.Asp27Asn Single submitter ⚠
- p.Glu381Lys Single submitter ⚠
- p.Gly125Glu Single submitter ⚠
- p.Gly343Asp Single submitter ⚠
- p.Ile119Val Single submitter ⚠
- p.Ile157Met Single submitter ⚠
- p.Ile209Met Single submitter ⚠
- p.Ile221Thr Single submitter ⚠
- p.Ile250Val Single submitter ⚠
- p.Ile378Asn Single submitter ⚠
- p.Leu28Phe Single submitter ⚠
- p.Leu82= Single submitter
- p.Leu84Phe Single submitter ⚠
- p.Leu87Val Single submitter ⚠
- p.Pro75Leu Single submitter ⚠
- p.Ser224Leu Single submitter ⚠
- p.Ser363Arg Single submitter ⚠
- p.Ser81Asn Single submitter ⚠
- p.Thr351Ile Single submitter ⚠
- p.Thr356Ile Single submitter ⚠
- p.Thr370Ile Single submitter ⚠
- p.Thr67Arg Single submitter ⚠
- p.Tyr231His Single submitter
- p.Val177Met Single submitter ⚠
- p.Val246Met Single submitter ⚠
- p.Val96Met Single submitter ⚠