GSK3A — 35 ClinVar variants
All ClinVar germline GSK3A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
1 Benign · 1 Likely benign · 33 Uncertain significance
Full GSK3A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GSK3A p.Ala139Thr Uncertain significance Single submitter
- GSK3A p.Ala294Asp Uncertain significance Single submitter
- GSK3A p.Ala378Thr Uncertain significance Single submitter
- GSK3A p.Arg391Ser Uncertain significance Single submitter
- GSK3A p.Asn171Ser Uncertain significance Single submitter
- GSK3A p.Glu116Lys Uncertain significance Single submitter
- GSK3A p.Gly42Ser Uncertain significance Single submitter
- GSK3A p.Gly48Ser Uncertain significance Single submitter
-
GSK3A p.Gly49Ala
Uncertain significance
Single submitter
dilated cardiomyopathy
- GSK3A p.Leu313Val Uncertain significance Single submitter
- GSK3A p.Met56Arg Uncertain significance Single submitter
- GSK3A p.Pro418Ser Uncertain significance Single submitter
- GSK3A p.Pro456Leu Uncertain significance Single submitter
- GSK3A p.Pro88Leu Uncertain significance Single submitter
- GSK3A p.Ser237Pro Uncertain significance Single submitter
- GSK3A p.Ser65Pro Uncertain significance Single submitter
- GSK3A p.Thr453Ile Uncertain significance Single submitter
- GSK3A p.Val330Gly Uncertain significance Single submitter
- GSK3A p.Val335Met Uncertain significance Single submitter
- GSK3A p.Val53Asp Uncertain significance Single submitter
- GSK3A p.Val53Gly Uncertain significance Single submitter
- GSK3A p.Val60Gly Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- GSK3A p.Arg113Pro Uncertain significance Single submitter
- GSK3A p.Arg272Gln Uncertain significance Single submitter
- GSK3A p.Asn127Ser Uncertain significance Single submitter
- GSK3A p.Gly68Arg Uncertain significance Single submitter
- GSK3A p.Gly81Asp Uncertain significance Single submitter
- GSK3A p.Pro421His Uncertain significance Single submitter
- GSK3A p.Ser370Phe Uncertain significance Single submitter
- GSK3A p.Ser77Arg Uncertain significance Single submitter
All GSK3A variants
Benign 1
- p.Tyr386= Single submitter
Likely benign 1
- p.Gly26= Single submitter
Uncertain significance 33
- c.1379-1G>T Single submitter
- p.Ala139Thr Single submitter ⚠
- p.Ala294Asp Single submitter ⚠
- p.Ala378Thr Single submitter ⚠
- p.Arg113Cys Single submitter
- p.Arg113Pro Single submitter ⚠
- p.Arg174Thr Single submitter
- p.Arg272Gln Single submitter ⚠
- p.Arg391Ser Single submitter ⚠
- p.Asn127Ser Single submitter ⚠
- p.Asn171Ser Single submitter ⚠
- p.Glu116Lys Single submitter ⚠
- p.Gly42Ser Single submitter ⚠
- p.Gly48Ser Single submitter ⚠
- p.Gly49Ala Single submitter dilated cardiomyopathy ⚠
- p.Gly68Arg Single submitter ⚠
- p.Gly81Asp Single submitter ⚠
- p.Leu313Val Single submitter ⚠
- p.Met56Arg Single submitter ⚠
- p.Pro418Ser Single submitter ⚠
- p.Pro421His Single submitter ⚠
- p.Pro456Leu Single submitter ⚠
- p.Pro88Leu Single submitter ⚠
- p.Ser237Pro Single submitter ⚠
- p.Ser370Phe Single submitter ⚠
- p.Ser65Pro Single submitter ⚠
- p.Ser77Arg Single submitter ⚠
- p.Thr453Ile Single submitter ⚠
- p.Val330Gly Single submitter ⚠
- p.Val335Met Single submitter ⚠
- p.Val53Asp Single submitter ⚠
- p.Val53Gly Single submitter ⚠
- p.Val60Gly Single submitter ⚠