GSTA1 — 31 ClinVar variants

All ClinVar germline GSTA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →

2 Benign · 1 Likely benign · 28 Uncertain significance

Full GSTA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 26

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 13

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 13

The independent predictors disagree with each other — read with care.

All GSTA1 variants

Benign 2

c.272+4C>T Single submitter
p.Pro5= Single submitter

Likely benign 1

p.Val58= Single submitter

Uncertain significance 28

p.Ala100Glu Single submitter ⚠
p.Ala70Pro Single submitter ⚠
p.Arg131Cys Single submitter ⚠
p.Arg13Trp Single submitter ⚠
p.Arg69Gly Single submitter ⚠
p.Asp146Glu Single submitter ⚠
p.Asp61Gly Single submitter ⚠
p.Glu17Lys Single submitter ⚠
p.Glu215Lys Single submitter ⚠
p.Glu31Gln Single submitter ⚠
p.Gly150Ser Single submitter
p.Leu102Phe Single submitter ⚠
p.Leu102Ser Single submitter ⚠
p.Leu164Pro Single submitter ⚠
p.Leu184Val Single submitter ⚠
p.Lys196Arg Single submitter ⚠
p.Lys36Arg Single submitter ⚠
p.Met57Ile Single submitter ⚠
p.Ser173Gly Single submitter ⚠
p.Ser177Arg Single submitter ⚠
p.Ser189Arg Single submitter ⚠
p.Thr186Ala Single submitter ⚠
p.Thr193Ile Single submitter ⚠
p.Thr19Ala Single submitter ⚠
p.Tyr132Cys Single submitter ⚠
p.Tyr95His Single submitter ⚠
p.Val149Ile Single submitter ⚠
p.Val58Ala Single submitter