GSTA2 — 32 ClinVar variants
All ClinVar germline GSTA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
6 Likely benign · 26 Uncertain significance
Full GSTA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GSTA2 p.Ala100Val Uncertain significance Single submitter
- GSTA2 p.Ala156Val Uncertain significance Single submitter
- GSTA2 p.Asn130Asp Uncertain significance Single submitter
- GSTA2 p.Asp118Gly Uncertain significance Single submitter
- GSTA2 p.Glu168Ala Uncertain significance Single submitter
- GSTA2 p.Gly150Val Uncertain significance Single submitter
- GSTA2 p.Ile60Asn Uncertain significance Single submitter
- GSTA2 p.Leu121Phe Uncertain significance Single submitter
- GSTA2 p.Leu170Phe Uncertain significance Single submitter
- GSTA2 p.Leu174Phe Uncertain significance Single submitter
- GSTA2 p.Leu81His Uncertain significance Single submitter
- GSTA2 p.Leu81Phe Uncertain significance Single submitter
- GSTA2 p.Met94Thr Uncertain significance Single submitter
- GSTA2 p.Ser18Pro Uncertain significance Single submitter
- GSTA2 p.Thr128Ile Uncertain significance Single submitter
- GSTA2 p.Tyr82Cys Uncertain significance Single submitter
- GSTA2 p.Val139Phe Uncertain significance Single submitter
- GSTA2 p.Val167Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- GSTA2 p.Leu107Pro Uncertain significance Single submitter
- GSTA2 p.Met57Val Uncertain significance Single submitter
- GSTA2 p.Met94Leu Uncertain significance Single submitter
- GSTA2 p.Phe133Leu Likely benign Single submitter
- GSTA2 p.Pro134Leu Uncertain significance Single submitter
- GSTA2 p.Pro200Arg Uncertain significance Single submitter
- GSTA2 p.Ser177Arg Uncertain significance Single submitter
- GSTA2 p.Thr193Ile Uncertain significance Single submitter
- GSTA2 p.Val149Phe Uncertain significance Single submitter
All GSTA2 variants
Likely benign 6
- p.Gln125Lys Single submitter
- p.Ile19Thr Single submitter
- p.Ile96Thr Single submitter
- p.Lys89Arg Single submitter
- p.Phe133Leu Single submitter ⚠
- p.Ser112Cys Single submitter
Uncertain significance 26
- p.Ala100Val Single submitter ⚠
- p.Ala156Val Single submitter ⚠
- p.Asn130Asp Single submitter ⚠
- p.Asp118Gly Single submitter ⚠
- p.Glu168Ala Single submitter ⚠
- p.Gly150Val Single submitter ⚠
- p.Ile60Asn Single submitter ⚠
- p.Leu107Pro Single submitter ⚠
- p.Leu121Phe Single submitter ⚠
- p.Leu170Phe Single submitter ⚠
- p.Leu174Phe Single submitter ⚠
- p.Leu81His Single submitter ⚠
- p.Leu81Phe Single submitter ⚠
- p.Met57Val Single submitter ⚠
- p.Met94Leu Single submitter ⚠
- p.Met94Thr Single submitter ⚠
- p.Pro134Leu Single submitter ⚠
- p.Pro200Arg Single submitter ⚠
- p.Ser177Arg Single submitter ⚠
- p.Ser18Pro Single submitter ⚠
- p.Thr128Ile Single submitter ⚠
- p.Thr193Ile Single submitter ⚠
- p.Tyr82Cys Single submitter ⚠
- p.Val139Phe Single submitter ⚠
- p.Val149Phe Single submitter ⚠
- p.Val167Met Single submitter ⚠