GSTK1 — 44 ClinVar variants
All ClinVar germline GSTK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
2 Benign · 3 Likely benign · 39 Uncertain significance
Full GSTK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GSTK1 p.Leu97Phe Uncertain significance Multiple submitters
- GSTK1 p.Ala207Val Uncertain significance Single submitter
- GSTK1 p.Arg202Gln Uncertain significance Single submitter
- GSTK1 p.Arg61Cys Uncertain significance Single submitter
- GSTK1 p.Arg61His Uncertain significance Single submitter
- GSTK1 p.Arg61Leu Uncertain significance Single submitter
- GSTK1 p.Asn68Ser Uncertain significance Single submitter
- GSTK1 p.Gly46Arg Uncertain significance Single submitter
- GSTK1 p.His189Arg Uncertain significance Single submitter
- GSTK1 p.Ile35Thr Uncertain significance Single submitter
- GSTK1 p.Ile44Val Uncertain significance Single submitter
- GSTK1 p.Leu197Phe Uncertain significance Single submitter
- GSTK1 p.Leu37Arg Uncertain significance Single submitter
- GSTK1 p.Met100Lys Uncertain significance Single submitter
- GSTK1 p.Met203Leu Uncertain significance Single submitter
- GSTK1 p.Pro184Arg Uncertain significance Single submitter
- GSTK1 p.Pro41Arg Uncertain significance Single submitter
- GSTK1 p.Pro84Leu Uncertain significance Single submitter
- GSTK1 p.Ser89Ala Uncertain significance Single submitter
- GSTK1 p.Thr7Ile Uncertain significance Single submitter
- GSTK1 p.Val14Met Uncertain significance Single submitter
- GSTK1 p.Val222Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- GSTK1 p.Ala105Thr Uncertain significance Single submitter
- GSTK1 p.Ala117Pro Uncertain significance Single submitter
- GSTK1 p.Arg128Gly Likely benign Single submitter
- GSTK1 p.Arg6Pro Uncertain significance Single submitter
- GSTK1 p.Glu134Lys Uncertain significance Single submitter
- GSTK1 p.Gly146Asp Uncertain significance Single submitter
- GSTK1 p.Gly179Glu Uncertain significance Single submitter
- GSTK1 p.Pro5Ser Uncertain significance Single submitter
- GSTK1 p.Trp20Arg Uncertain significance Single submitter
- GSTK1 p.Trp20Cys Uncertain significance Single submitter
All GSTK1 variants
Benign 2
- c.632-4C>G Multiple submitters
- p.Thr186= Multiple submitters
Likely benign 3
- p.Ala117Val Single submitter
- p.Arg128Gly Single submitter ⚠
- p.Pro5Leu Single submitter
Uncertain significance 39
- p.Leu97Phe Multiple submitters ⚠
- c.384+33G>C Single submitter
- c.384+35C>T Single submitter
- c.385-36C>G Single submitter
- c.385-45C>T Single submitter
- c.385-68G>T Single submitter
- c.385-77C>G Single submitter
- p.Ala105Thr Single submitter ⚠
- p.Ala117Pro Single submitter ⚠
- p.Ala207Val Single submitter ⚠
- p.Arg202Gln Single submitter ⚠
- p.Arg61Cys Single submitter ⚠
- p.Arg61His Single submitter ⚠
- p.Arg61Leu Single submitter ⚠
- p.Arg6Pro Single submitter ⚠
- p.Asn68Ser Single submitter ⚠
- p.Glu134Lys Single submitter ⚠
- p.Gly146Asp Single submitter ⚠
- p.Gly179Glu Single submitter ⚠
- p.Gly46Arg Single submitter ⚠
- p.His189Arg Single submitter ⚠
- p.Ile35Thr Single submitter ⚠
- p.Ile44Val Single submitter ⚠
- p.Leu197Phe Single submitter ⚠
- p.Leu37Arg Single submitter ⚠
- p.Met100Lys Single submitter ⚠
- p.Met203Leu Single submitter ⚠
- p.Pro184Arg Single submitter ⚠
- p.Pro41Arg Single submitter ⚠
- p.Pro5Ser Single submitter ⚠
- p.Pro84Leu Single submitter ⚠
- p.Ser89Ala Single submitter ⚠
- p.Thr7Ile Single submitter ⚠
- p.Trp20Arg Single submitter ⚠
- p.Trp20Cys Single submitter ⚠
- p.Tyr65His Single submitter
- p.Val14Met Single submitter ⚠
- p.Val187Met Single submitter
- p.Val222Met Single submitter ⚠