GSTM1 — 19 ClinVar variants
All ClinVar germline GSTM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
3 Benign · 4 Likely benign · 12 Uncertain significance
Full GSTM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GSTM1 p.Arg82His Uncertain significance Single submitter
- GSTM1 p.Arg96Pro Uncertain significance Single submitter
- GSTM1 p.Asn48Ser Uncertain significance Single submitter
- GSTM1 p.Asp165Glu Uncertain significance Single submitter
- GSTM1 p.Leu204Pro Uncertain significance Single submitter
- GSTM1 p.Lys173Arg Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- GSTM1 p.Arg145Trp Benign Single submitter
- GSTM1 p.Asn102Lys Uncertain significance Single submitter
- GSTM1 p.Asn107Lys Uncertain significance Single submitter
- GSTM1 p.Leu128Ser Uncertain significance Single submitter
- GSTM1 p.Lys126Thr Uncertain significance Single submitter
- GSTM1 p.Ser44Arg Uncertain significance Single submitter
- GSTM1 p.Tyr7Cys Uncertain significance Single submitter
All GSTM1 variants
Benign 3
- p.Arg145Trp Single submitter ⚠
- p.Arg96Leu Single submitter
- p.Met105Thr Single submitter
Likely benign 4
- p.His15Gln Single submitter
- p.Ile4Thr Single submitter
- p.Leu159Val Single submitter
- p.Arg82Cys No assertion criteria GSTM1-related disorder
Uncertain significance 12
- p.Arg82His Single submitter ⚠
- p.Arg96Pro Single submitter ⚠
- p.Asn102Lys Single submitter ⚠
- p.Asn107Lys Single submitter ⚠
- p.Asn48Ser Single submitter ⚠
- p.Asp165Glu Single submitter ⚠
- p.Leu128Ser Single submitter ⚠
- p.Leu204Pro Single submitter ⚠
- p.Lys126Thr Single submitter ⚠
- p.Lys173Arg Single submitter ⚠
- p.Ser44Arg Single submitter ⚠
- p.Tyr7Cys Single submitter ⚠