GSTM2 — 21 ClinVar variants

All ClinVar germline GSTM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →

2 Benign · 2 Likely benign · 17 Uncertain significance

Full GSTM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 17

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 4

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 13

The independent predictors disagree with each other — read with care.

All GSTM2 variants

Benign 2

p.Arg78= Multiple submitters
c.259+3G>A Single submitter

Likely benign 2

p.Gln145Arg Single submitter
p.Lys218= Single submitter

Uncertain significance 17

p.Ala112Thr Single submitter ⚠
p.Ala196Asp Single submitter ⚠
p.Arg108Gly Single submitter ⚠
p.Arg82Gly Single submitter ⚠
p.Asp162Tyr Single submitter ⚠
p.Asp42Asn Single submitter ⚠
p.Gln94His Single submitter ⚠
p.Ile10Phe Single submitter ⚠
p.Ile95Met Single submitter ⚠
p.Leu191Met Single submitter ⚠
p.Lys211Asn Single submitter ⚠
p.Lys31Asn Single submitter ⚠
p.Phe51Leu Single submitter ⚠
p.Pro125Leu Single submitter ⚠
p.Thr24Ile Single submitter ⚠
p.Tyr116Cys Single submitter ⚠
p.Tyr138Cys Single submitter ⚠