GSTO1 — 34 ClinVar variants
All ClinVar germline GSTO1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
3 Benign · 4 Likely benign · 27 Uncertain significance
Full GSTO1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GSTO1 p.Ala214Thr Uncertain significance Single submitter
- GSTO1 p.Asn67Lys Uncertain significance Single submitter
- GSTO1 p.Asp209Glu Uncertain significance Single submitter
- GSTO1 p.Cys90Phe Uncertain significance Single submitter
- GSTO1 p.Gln231Arg Uncertain significance Single submitter
- GSTO1 p.Ile173Thr Uncertain significance Single submitter
- GSTO1 p.Ile52Thr Uncertain significance Single submitter
- GSTO1 p.Leu153Arg Uncertain significance Single submitter
- GSTO1 p.Lys110Glu Uncertain significance Single submitter
- GSTO1 p.Lys148Glu Uncertain significance Single submitter
- GSTO1 p.Lys45Glu Uncertain significance Single submitter
- GSTO1 p.Pro20Leu Uncertain significance Single submitter
- GSTO1 p.Pro234Leu Uncertain significance Single submitter
- GSTO1 p.Ser125Tyr Uncertain significance Single submitter
- GSTO1 p.Ser133Asn Uncertain significance Single submitter
- GSTO1 p.Val72Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- GSTO1 p.Gln231Pro Uncertain significance Single submitter
- GSTO1 p.Glu182Lys Uncertain significance Single submitter
- GSTO1 p.Glu61Gln Uncertain significance Single submitter
- GSTO1 p.Leu56Val Uncertain significance Single submitter
- GSTO1 p.Lys161Thr Uncertain significance Single submitter
- GSTO1 p.Phe130Ser Uncertain significance Single submitter
- GSTO1 p.Pro73Ser Uncertain significance Single submitter
- GSTO1 p.Thr162Met Uncertain significance Single submitter
- GSTO1 p.Tyr239Cys Uncertain significance Single submitter
All GSTO1 variants
Benign 3
- c.34+5G>A Multiple submitters
- p.Arg7Lys Multiple submitters
- p.Ala140Asp No assertion criteria GSTO1-related disorder
Likely benign 4
- c.34+7C>A Single submitter
- p.Ser125Pro Single submitter
- p.Thr163Ile Single submitter
- c.464_465+1del No assertion criteria GSTO1-related disorder
Uncertain significance 27
- p.Ala111Gly Single submitter
- p.Ala214Thr Single submitter ⚠
- p.Asn67Lys Single submitter ⚠
- p.Asp209Glu Single submitter ⚠
- p.Cys90Phe Single submitter ⚠
- p.Gln231Arg Single submitter ⚠
- p.Gln231Pro Single submitter ⚠
- p.Glu182Lys Single submitter ⚠
- p.Glu61Gln Single submitter ⚠
- p.Ile173Thr Single submitter ⚠
- p.Ile52Thr Single submitter ⚠
- p.Leu153Arg Single submitter ⚠
- p.Leu56Val Single submitter ⚠
- p.Lys110Glu Single submitter ⚠
- p.Lys148Glu Single submitter ⚠
- p.Lys161Thr Single submitter ⚠
- p.Lys45Glu Single submitter ⚠
- p.Phe130Ser Single submitter ⚠
- p.Pro20Leu Single submitter ⚠
- p.Pro234Leu Single submitter ⚠
- p.Pro73Ser Single submitter ⚠
- p.Ser125Tyr Single submitter ⚠
- p.Ser133Asn Single submitter ⚠
- p.Thr162Met Single submitter ⚠
- p.Tyr239Cys Single submitter ⚠
- p.Val41Ala Single submitter
- p.Val72Leu Single submitter ⚠