GSTP1 — 32 ClinVar variants
All ClinVar germline GSTP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
1 Likely pathogenic · 12 Benign · 1 Likely benign · 18 Uncertain significance
Full GSTP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GSTP1 p.Ala186Thr Uncertain significance Single submitter
- GSTP1 p.Ala23Val Uncertain significance Single submitter
- GSTP1 p.Arg14Pro Uncertain significance Single submitter
- GSTP1 p.Arg19Gly Uncertain significance Single submitter
- GSTP1 p.Glu198Ala Uncertain significance Single submitter
- GSTP1 p.Ile162Leu Uncertain significance Single submitter
- GSTP1 p.Leu166Val Uncertain significance Single submitter
- GSTP1 p.Ser150Phe Uncertain significance Single submitter
- GSTP1 p.Ser28Asn Uncertain significance Single submitter
- GSTP1 p.Ser47Thr Uncertain significance Single submitter
- GSTP1 p.Ser66Tyr Uncertain significance Single submitter
- GSTP1 p.Tyr154His Uncertain significance Single submitter
- GSTP1 p.Val200Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All GSTP1 variants
Likely pathogenic 1
- c.336+79_336+80delinsCA No assertion criteria susceptibility to visceral leishmaniasis, 2
Benign 12
- c.2-20C>G Multiple submitters
- c.2-65A>G Multiple submitters
- c.2-74G>A Multiple submitters
- c.232+13C>A Multiple submitters
- c.337-322G>A Multiple submitters
- c.37+134C>T Multiple submitters
- c.445-16C>T Multiple submitters
- c.-18G>A Multiple submitters
- p.Ala114Val Multiple submitters pulmonary disease, chronic obstructive, susceptibility to
- p.Ile105Val Multiple submitters
- p.Ser185= Multiple submitters
- p.Tyr50= Multiple submitters
Likely benign 1
- p.Ala173= Single submitter
Uncertain significance 18
- p.Ala152Thr Single submitter ⚠
- p.Ala186Thr Single submitter ⚠
- p.Ala23Val Single submitter ⚠
- p.Arg14Pro Single submitter ⚠
- p.Arg19Gly Single submitter ⚠
- p.Asn207His Single submitter ⚠
- p.Glu198Ala Single submitter ⚠
- p.Ile162Leu Single submitter ⚠
- p.Leu166Val Single submitter ⚠
- p.Phe130Val Single submitter ⚠
- p.Phe174Ile Single submitter ⚠
- p.Pro188Leu Single submitter ⚠
- p.Ser150Phe Single submitter ⚠
- p.Ser28Asn Single submitter ⚠
- p.Ser47Thr Single submitter ⚠
- p.Ser66Tyr Single submitter ⚠
- p.Tyr154His Single submitter ⚠
- p.Val200Met Single submitter ⚠