GTF3C4 — 73 ClinVar variants
All ClinVar germline GTF3C4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
4 Likely benign · 69 Uncertain significance
Full GTF3C4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GTF3C4 p.Ala349Val Uncertain significance Single submitter
- GTF3C4 p.Ala40Thr Uncertain significance Single submitter
- GTF3C4 p.Ala560Thr Uncertain significance Single submitter
- GTF3C4 p.Ala7Val Uncertain significance Single submitter
- GTF3C4 p.Arg190Cys Uncertain significance Single submitter
- GTF3C4 p.Arg48His Uncertain significance Single submitter
- GTF3C4 p.Arg759His Uncertain significance Single submitter
- GTF3C4 p.Arg84Ser Uncertain significance Single submitter
- GTF3C4 p.Asn114Asp Uncertain significance Single submitter
- GTF3C4 p.Asn189Asp Uncertain significance Single submitter
- GTF3C4 p.Asn2Lys Uncertain significance Single submitter
- GTF3C4 p.Asn324Ser Uncertain significance Single submitter
- GTF3C4 p.Asn325Ser Uncertain significance Single submitter
- GTF3C4 p.Asn714Asp Uncertain significance Single submitter
- GTF3C4 p.Asn766Ser Uncertain significance Single submitter
- GTF3C4 p.Asp101Gly Uncertain significance Single submitter
- GTF3C4 p.Asp14Asn Uncertain significance Single submitter
- GTF3C4 p.Gln524His Uncertain significance Single submitter
- GTF3C4 p.Gln61Arg Uncertain significance Single submitter
- GTF3C4 p.Gln637Leu Uncertain significance Single submitter
- GTF3C4 p.Glu602Ala Uncertain significance Single submitter
- GTF3C4 p.Glu624Asp Uncertain significance Single submitter
- GTF3C4 p.Glu646Gln Uncertain significance Single submitter
- GTF3C4 p.Gly26Ala Uncertain significance Single submitter
- GTF3C4 p.Gly486Ser Uncertain significance Single submitter
- GTF3C4 p.Gly500Ser Uncertain significance Single submitter
- GTF3C4 p.His791Leu Uncertain significance Single submitter
- GTF3C4 p.Ile256Met Uncertain significance Single submitter
- GTF3C4 p.Ile340Met Uncertain significance Single submitter
- GTF3C4 p.Ile540Thr Uncertain significance Single submitter
- GTF3C4 p.Leu539Val Uncertain significance Single submitter
- GTF3C4 p.Lys137Arg Uncertain significance Single submitter
- GTF3C4 p.Lys225Asn Uncertain significance Single submitter
- GTF3C4 p.Lys598Asn Uncertain significance Single submitter
- GTF3C4 p.Met161Val Uncertain significance Single submitter
- GTF3C4 p.Met187Val Uncertain significance Single submitter
- GTF3C4 p.Pro110Ser Uncertain significance Single submitter
- GTF3C4 p.Pro11Leu Uncertain significance Single submitter
- GTF3C4 p.Pro11Ser Uncertain significance Single submitter
- GTF3C4 p.Pro16Leu Uncertain significance Single submitter
- GTF3C4 p.Pro293Leu Uncertain significance Single submitter
- GTF3C4 p.Pro35Leu Uncertain significance Single submitter
- GTF3C4 p.Pro43Ser Uncertain significance Single submitter
- GTF3C4 p.Pro554Ser Uncertain significance Single submitter
- GTF3C4 p.Pro800Ser Uncertain significance Single submitter
- GTF3C4 p.Ser312Phe Uncertain significance Single submitter
- GTF3C4 p.Ser314Asn Uncertain significance Single submitter
- GTF3C4 p.Ser387Asn Uncertain significance Single submitter
- GTF3C4 p.Ser529Leu Uncertain significance Single submitter
- GTF3C4 p.Ser604Leu Uncertain significance Single submitter
- GTF3C4 p.Ser627Tyr Uncertain significance Single submitter
- GTF3C4 p.Ser765Cys Uncertain significance Single submitter
- GTF3C4 p.Thr107Ser Uncertain significance Single submitter
- GTF3C4 p.Thr167Ser Uncertain significance Single submitter
- GTF3C4 p.Thr3Ala Uncertain significance Single submitter
- GTF3C4 p.Thr3Met Uncertain significance Single submitter
- GTF3C4 p.Thr494Ala Uncertain significance Single submitter
- GTF3C4 p.Thr52Ser Uncertain significance Single submitter
- GTF3C4 p.Thr684Ala Uncertain significance Single submitter
- GTF3C4 p.Tyr62Cys Uncertain significance Single submitter
- GTF3C4 p.Val262Ile Uncertain significance Single submitter
- GTF3C4 p.Val9Glu Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All GTF3C4 variants
Likely benign 4
- p.Glu90= Single submitter
- p.Gly234Arg Single submitter
- p.Ile340Val Single submitter
- p.Thr655Pro Single submitter
Uncertain significance 69
- p.Ala349Val Single submitter ⚠
- p.Ala40Thr Single submitter ⚠
- p.Ala560Thr Single submitter ⚠
- p.Ala7Val Single submitter ⚠
- p.Arg190Cys Single submitter ⚠
- p.Arg326Gly Single submitter ⚠
- p.Arg48His Single submitter ⚠
- p.Arg53Trp Single submitter ⚠
- p.Arg759His Single submitter ⚠
- p.Arg84Ser Single submitter ⚠
- p.Asn114Asp Single submitter ⚠
- p.Asn189Asp Single submitter ⚠
- p.Asn2Lys Single submitter ⚠
- p.Asn324Ser Single submitter ⚠
- p.Asn325Ser Single submitter ⚠
- p.Asn714Asp Single submitter ⚠
- p.Asn766Ser Single submitter ⚠
- p.Asp101Gly Single submitter ⚠
- p.Asp14Asn Single submitter ⚠
- p.Gln524His Single submitter ⚠
- p.Gln61Arg Single submitter ⚠
- p.Gln637Leu Single submitter ⚠
- p.Glu602Ala Single submitter ⚠
- p.Glu624Asp Single submitter ⚠
- p.Glu646Gln Single submitter ⚠
- p.Gly26Ala Single submitter ⚠
- p.Gly486Ser Single submitter ⚠
- p.Gly500Ser Single submitter ⚠
- p.Gly66Ser Single submitter
- p.His417Tyr Single submitter ⚠
- p.His791Leu Single submitter ⚠
- p.Ile256Met Single submitter ⚠
- p.Ile340Met Single submitter ⚠
- p.Ile540Thr Single submitter ⚠
- p.Leu200Pro Single submitter ⚠
- p.Leu539Val Single submitter ⚠
- p.Lys137Arg Single submitter ⚠
- p.Lys225Asn Single submitter ⚠
- p.Lys598Asn Single submitter ⚠
- p.Met161Val Single submitter ⚠
- p.Met187Val Single submitter ⚠
- p.Pro110Ser Single submitter ⚠
- p.Pro11Leu Single submitter ⚠
- p.Pro11Ser Single submitter ⚠
- p.Pro153Ser Single submitter
- p.Pro16Leu Single submitter ⚠
- p.Pro293Leu Single submitter ⚠
- p.Pro35Leu Single submitter ⚠
- p.Pro43Ser Single submitter ⚠
- p.Pro554Ser Single submitter ⚠
- p.Pro800Ser Single submitter ⚠
- p.Ser312Phe Single submitter ⚠
- p.Ser314Asn Single submitter ⚠
- p.Ser387Asn Single submitter ⚠
- p.Ser529Leu Single submitter ⚠
- p.Ser604Leu Single submitter ⚠
- p.Ser627Tyr Single submitter ⚠
- p.Ser765Cys Single submitter ⚠
- p.Thr107Ser Single submitter ⚠
- p.Thr167Ser Single submitter ⚠
- p.Thr3Ala Single submitter ⚠
- p.Thr3Met Single submitter ⚠
- p.Thr494Ala Single submitter ⚠
- p.Thr52Ser Single submitter ⚠
- p.Thr684Ala Single submitter ⚠
- p.Tyr62Cys Single submitter ⚠
- p.Val262Ile Single submitter ⚠
- p.Val287Met Single submitter
- p.Val9Glu Single submitter ⚠