GYPA — 21 ClinVar variants
All ClinVar germline GYPA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
1 Pathogenic · 4 Likely benign · 16 Uncertain significance
Full GYPA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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GYPA p.Gly78Arg
Pathogenic
No assertion criteria
BLOOD GROUP ERIK
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GYPA p.Arg115Ser Uncertain significance Single submitter
- GYPA p.Arg116Leu Uncertain significance Single submitter
- GYPA p.Gln82Arg Uncertain significance Single submitter
- GYPA p.Gly102Ser Uncertain significance Single submitter
- GYPA p.Gly113Ser Uncertain significance Single submitter
- GYPA p.Pro122Leu Uncertain significance Single submitter
- GYPA p.Pro145Thr Uncertain significance Single submitter
- GYPA p.Pro57Thr Uncertain significance Single submitter
- GYPA p.Ser138Asn Uncertain significance Single submitter
- GYPA p.Thr106Met Uncertain significance Single submitter
- GYPA p.Thr23Asn Uncertain significance Single submitter
- GYPA p.Thr69Ala Uncertain significance Single submitter
- GYPA p.Val135Met Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All GYPA variants
Pathogenic 1
- p.Gly78Arg No assertion criteria BLOOD GROUP ERIK ⚠
Likely benign 4
- c.38-19C>T Single submitter
- p.Ala84Val Single submitter
- p.Met27Thr Single submitter
- p.Pro122Ser Single submitter
Uncertain significance 16
- p.Arg115Ser Single submitter ⚠
- p.Arg116Leu Single submitter ⚠
- p.Gln82Arg Single submitter ⚠
- p.Gly102Asp Single submitter ⚠
- p.Gly102Ser Single submitter ⚠
- p.Gly113Ser Single submitter ⚠
- p.Ile95Thr Single submitter ⚠
- p.Leu94Arg Single submitter ⚠
- p.Pro122Leu Single submitter ⚠
- p.Pro145Thr Single submitter ⚠
- p.Pro57Thr Single submitter ⚠
- p.Ser138Asn Single submitter ⚠
- p.Thr106Met Single submitter ⚠
- p.Thr23Asn Single submitter ⚠
- p.Thr69Ala Single submitter ⚠
- p.Val135Met Single submitter ⚠