H1-5 — 56 ClinVar variants
All ClinVar germline H1-5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
56 Uncertain significance
Full H1-5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- H1-5 p.Ala104Val Uncertain significance Single submitter
- H1-5 p.Ala129Thr Uncertain significance Single submitter
- H1-5 p.Ala135Val Uncertain significance Single submitter
- H1-5 p.Ala137Thr Uncertain significance Single submitter
- H1-5 p.Ala142Val Uncertain significance Single submitter
- H1-5 p.Ala145Thr Uncertain significance Single submitter
- H1-5 p.Ala145Val Uncertain significance Single submitter
- H1-5 p.Ala148Val Uncertain significance Single submitter
- H1-5 p.Ala151Val Uncertain significance Single submitter
- H1-5 p.Ala177Thr Uncertain significance Single submitter
- H1-5 p.Ala180Thr Uncertain significance Single submitter
- H1-5 p.Ala216Val Uncertain significance Single submitter
- H1-5 p.Ala218Val Uncertain significance Single submitter
- H1-5 p.Ala221Val Uncertain significance Single submitter
- H1-5 p.Ala223Thr Uncertain significance Single submitter
- H1-5 p.Ala28Val Uncertain significance Single submitter
- H1-5 p.Ala5Val Uncertain significance Single submitter
- H1-5 p.Ala64Thr Uncertain significance Single submitter
- H1-5 p.Gly147Ala Uncertain significance Single submitter
- H1-5 p.Gly40Val Uncertain significance Single submitter
- H1-5 p.Leu87Val Uncertain significance Single submitter
- H1-5 p.Lys132Arg Uncertain significance Single submitter
- H1-5 p.Lys178Arg Uncertain significance Single submitter
- H1-5 p.Lys192Arg Uncertain significance Single submitter
- H1-5 p.Lys217Thr Uncertain significance Single submitter
- H1-5 p.Lys22Arg Uncertain significance Single submitter
- H1-5 p.Ser61Phe Uncertain significance Single submitter
- H1-5 p.Thr187Ile Uncertain significance Single submitter
- H1-5 p.Val15Leu Uncertain significance Single submitter
- H1-5 p.Val196Ile Uncertain significance Single submitter
- H1-5 p.Val97Leu Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- H1-5 p.Ala163Pro Uncertain significance Single submitter
- H1-5 p.Ala211Glu Uncertain significance Single submitter
- H1-5 p.Ala211Pro Uncertain significance Single submitter
- H1-5 p.Ala68Thr Uncertain significance Single submitter
- H1-5 p.Gly30Asp Uncertain significance Single submitter
- H1-5 p.Gly40Trp Uncertain significance Single submitter
- H1-5 p.Ile83Val Uncertain significance Single submitter
- H1-5 p.Lys133Glu Uncertain significance Single submitter
- H1-5 p.Lys141Asn Uncertain significance Single submitter
- H1-5 p.Lys168Arg Uncertain significance Single submitter
- H1-5 p.Lys182Gln Uncertain significance Single submitter
- H1-5 p.Lys199Asn Uncertain significance Single submitter
- H1-5 p.Pro121His Uncertain significance Single submitter
- H1-5 p.Pro162Leu Uncertain significance Single submitter
- H1-5 p.Pro190Leu Uncertain significance Single submitter
- H1-5 p.Pro19Leu Uncertain significance Single submitter
- H1-5 p.Pro203Ser Uncertain significance Single submitter
- H1-5 p.Pro213Leu Uncertain significance Single submitter
- H1-5 p.Ser173Asn Uncertain significance Single submitter
- H1-5 p.Thr102Ser Uncertain significance Single submitter
- H1-5 p.Thr25Ile Uncertain significance Single submitter
- H1-5 p.Thr39Met Uncertain significance Single submitter
- H1-5 p.Val152Met Uncertain significance Single submitter
- H1-5 p.Val43Ala Uncertain significance Single submitter
- H1-5 p.Val51Met Uncertain significance Single submitter
All H1-5 variants
Uncertain significance 56
- p.Ala104Val Single submitter ⚠
- p.Ala129Thr Single submitter ⚠
- p.Ala135Val Single submitter ⚠
- p.Ala137Thr Single submitter ⚠
- p.Ala142Val Single submitter ⚠
- p.Ala145Thr Single submitter ⚠
- p.Ala145Val Single submitter ⚠
- p.Ala148Val Single submitter ⚠
- p.Ala151Val Single submitter ⚠
- p.Ala163Pro Single submitter ⚠
- p.Ala177Thr Single submitter ⚠
- p.Ala180Thr Single submitter ⚠
- p.Ala211Glu Single submitter ⚠
- p.Ala211Pro Single submitter ⚠
- p.Ala216Val Single submitter ⚠
- p.Ala218Val Single submitter ⚠
- p.Ala221Val Single submitter ⚠
- p.Ala223Thr Single submitter ⚠
- p.Ala28Val Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Ala64Thr Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Gly147Ala Single submitter ⚠
- p.Gly30Asp Single submitter ⚠
- p.Gly40Trp Single submitter ⚠
- p.Gly40Val Single submitter ⚠
- p.Ile83Val Single submitter ⚠
- p.Leu87Val Single submitter ⚠
- p.Lys132Arg Single submitter ⚠
- p.Lys133Glu Single submitter ⚠
- p.Lys141Asn Single submitter ⚠
- p.Lys168Arg Single submitter ⚠
- p.Lys178Arg Single submitter ⚠
- p.Lys182Gln Single submitter ⚠
- p.Lys192Arg Single submitter ⚠
- p.Lys199Asn Single submitter ⚠
- p.Lys217Thr Single submitter ⚠
- p.Lys22Arg Single submitter ⚠
- p.Pro121His Single submitter ⚠
- p.Pro162Leu Single submitter ⚠
- p.Pro190Leu Single submitter ⚠
- p.Pro19Leu Single submitter ⚠
- p.Pro203Ser Single submitter ⚠
- p.Pro213Leu Single submitter ⚠
- p.Ser173Asn Single submitter ⚠
- p.Ser61Phe Single submitter ⚠
- p.Thr102Ser Single submitter ⚠
- p.Thr187Ile Single submitter ⚠
- p.Thr25Ile Single submitter ⚠
- p.Thr39Met Single submitter ⚠
- p.Val152Met Single submitter ⚠
- p.Val15Leu Single submitter ⚠
- p.Val196Ile Single submitter ⚠
- p.Val43Ala Single submitter ⚠
- p.Val51Met Single submitter ⚠
- p.Val97Leu Single submitter ⚠