HAT1 — 32 ClinVar variants
All ClinVar germline HAT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
32 Uncertain significance
Full HAT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HAT1 p.Arg330Ser Uncertain significance Single submitter
- HAT1 p.Arg349Lys Uncertain significance Single submitter
- HAT1 p.Arg410Trp Uncertain significance Single submitter
- HAT1 p.Arg411Cys Uncertain significance Single submitter
- HAT1 p.Asp47Gly Uncertain significance Single submitter
- HAT1 p.Cys120Ser Uncertain significance Single submitter
- HAT1 p.His175Arg Uncertain significance Single submitter
- HAT1 p.Ile33Thr Uncertain significance Single submitter
- HAT1 p.Ile355Val Uncertain significance Single submitter
- HAT1 p.Ile413Val Uncertain significance Single submitter
- HAT1 p.Lys366Arg Uncertain significance Single submitter
- HAT1 p.Met166Val Uncertain significance Single submitter
- HAT1 p.Met222Val Uncertain significance Single submitter
- HAT1 p.Phe10Tyr Uncertain significance Single submitter
- HAT1 p.Pro231Ser Uncertain significance Single submitter
- HAT1 p.Ser128Phe Uncertain significance Single submitter
- HAT1 p.Ser150Arg Uncertain significance Single submitter
- HAT1 p.Ser343Asn Uncertain significance Single submitter
- HAT1 p.Ser401Thr Uncertain significance Single submitter
- HAT1 p.Thr383Ile Uncertain significance Single submitter
- HAT1 p.Tyr174His Uncertain significance Single submitter
- HAT1 p.Val194Met Uncertain significance Single submitter
- HAT1 p.Val219Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- HAT1 p.Arg349Gly Uncertain significance Single submitter
- HAT1 p.Asn122Lys Uncertain significance Single submitter
- HAT1 p.Ile161Met Uncertain significance Single submitter
- HAT1 p.Ile355Thr Uncertain significance Single submitter
- HAT1 p.Ser150Gly Uncertain significance Single submitter
- HAT1 p.Ser281Cys Uncertain significance Single submitter
All HAT1 variants
Uncertain significance 32
- p.Ala32Thr Single submitter
- p.Arg330Ser Single submitter ⚠
- p.Arg349Gly Single submitter ⚠
- p.Arg349Lys Single submitter ⚠
- p.Arg410Trp Single submitter ⚠
- p.Arg411Cys Single submitter ⚠
- p.Asn122Lys Single submitter ⚠
- p.Asp47Gly Single submitter ⚠
- p.Cys120Ser Single submitter ⚠
- p.His175Arg Single submitter ⚠
- p.Ile161Met Single submitter ⚠
- p.Ile33Thr Single submitter ⚠
- p.Ile355Thr Single submitter ⚠
- p.Ile355Val Single submitter ⚠
- p.Ile413Val Single submitter ⚠
- p.Lys366Arg Single submitter ⚠
- p.Met166Val Single submitter ⚠
- p.Met222Val Single submitter ⚠
- p.Met313Thr Single submitter
- p.Phe10Tyr Single submitter ⚠
- p.Pro231Ser Single submitter ⚠
- p.Ser128Phe Single submitter ⚠
- p.Ser150Arg Single submitter ⚠
- p.Ser150Gly Single submitter ⚠
- p.Ser281Cys Single submitter ⚠
- p.Ser343Asn Single submitter ⚠
- p.Ser401Thr Single submitter ⚠
- p.Thr383Ile Single submitter ⚠
- p.Tyr174His Single submitter ⚠
- p.Tyr351Cys Single submitter
- p.Val194Met Single submitter ⚠
- p.Val219Ile Single submitter ⚠