HCAR3 — 61 ClinVar variants
All ClinVar germline HCAR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
9 Likely benign · 52 Uncertain significance
Full HCAR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HCAR3 p.Ala135Thr Uncertain significance Single submitter
- HCAR3 p.Ala341Thr Uncertain significance Single submitter
- HCAR3 p.Ala344Glu Uncertain significance Single submitter
- HCAR3 p.Arg101Trp Uncertain significance Single submitter
- HCAR3 p.Arg111His Uncertain significance Single submitter
- HCAR3 p.Arg128Gln Uncertain significance Single submitter
- HCAR3 p.Arg216Gln Uncertain significance Single submitter
- HCAR3 p.Arg22Gln Uncertain significance Single submitter
- HCAR3 p.Arg251Gln Uncertain significance Single submitter
- HCAR3 p.Arg63Gly Uncertain significance Single submitter
- HCAR3 p.Arg90Cys Uncertain significance Single submitter
- HCAR3 p.Asn110Lys Uncertain significance Single submitter
- HCAR3 p.Asn17Ile Uncertain significance Single submitter
- HCAR3 p.Asn17Ser Uncertain significance Single submitter
- HCAR3 p.Asn286Asp Uncertain significance Single submitter
- HCAR3 p.Asn310Lys Uncertain significance Single submitter
- HCAR3 p.Asn364Asp Uncertain significance Single submitter
- HCAR3 p.Asp221Val Uncertain significance Single submitter
- HCAR3 p.Cys100Tyr Uncertain significance Single submitter
- HCAR3 p.Cys371Tyr Uncertain significance Single submitter
- HCAR3 p.Cys384Tyr Uncertain significance Single submitter
- HCAR3 p.Gln7Arg Uncertain significance Single submitter
- HCAR3 p.Gly319Asp Uncertain significance Single submitter
- HCAR3 p.Gly369Arg Uncertain significance Single submitter
- HCAR3 p.His184Arg Uncertain significance Single submitter
- HCAR3 p.His253Tyr Uncertain significance Single submitter
- HCAR3 p.Ile146Thr Uncertain significance Single submitter
- HCAR3 p.Ile169Met Uncertain significance Single submitter
- HCAR3 p.Ile77Val Uncertain significance Single submitter
- HCAR3 p.Leu331Phe Uncertain significance Single submitter
- HCAR3 p.Leu345Phe Uncertain significance Single submitter
- HCAR3 p.Leu34Phe Uncertain significance Single submitter
- HCAR3 p.Lys15Glu Uncertain significance Single submitter
- HCAR3 p.Lys164Glu Uncertain significance Single submitter
- HCAR3 p.Ser114Asn Uncertain significance Single submitter
- HCAR3 p.Ser181Asn Uncertain significance Single submitter
- HCAR3 p.Ser271Leu Uncertain significance Single submitter
- HCAR3 p.Ser326Arg Uncertain significance Single submitter
- HCAR3 p.Thr119Pro Uncertain significance Single submitter
- HCAR3 p.Thr263Met Uncertain significance Single submitter
- HCAR3 p.Thr307Asn Uncertain significance Single submitter
- HCAR3 p.Trp353Arg Uncertain significance Single submitter
- HCAR3 p.Val130Ile Uncertain significance Single submitter
- HCAR3 p.Val156Leu Uncertain significance Single submitter
- HCAR3 p.Val329Ile Uncertain significance Single submitter
- HCAR3 p.Val83Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- HCAR3 p.Ala122Val Uncertain significance Single submitter
- HCAR3 p.Arg270Cys Uncertain significance Single submitter
- HCAR3 p.Ile13Thr Uncertain significance Single submitter
- HCAR3 p.Phe21Ser Uncertain significance Single submitter
- HCAR3 p.Pro31Leu Uncertain significance Single submitter
- HCAR3 p.Ser181Arg Uncertain significance Single submitter
All HCAR3 variants
Likely benign 9
- p.Arg315Lys Single submitter
- p.Glu330= Single submitter
- p.His259Tyr Single submitter
- p.Leu168Pro Single submitter
- p.Ser261Leu Single submitter
- p.Thr327= Single submitter
- p.Val103Met Single submitter
- p.Val156Ile Single submitter
- p.Val176Leu Single submitter
Uncertain significance 52
- p.Ala122Val Single submitter ⚠
- p.Ala135Thr Single submitter ⚠
- p.Ala341Thr Single submitter ⚠
- p.Ala344Glu Single submitter ⚠
- p.Arg101Trp Single submitter ⚠
- p.Arg111His Single submitter ⚠
- p.Arg128Gln Single submitter ⚠
- p.Arg216Gln Single submitter ⚠
- p.Arg22Gln Single submitter ⚠
- p.Arg251Gln Single submitter ⚠
- p.Arg270Cys Single submitter ⚠
- p.Arg63Gly Single submitter ⚠
- p.Arg90Cys Single submitter ⚠
- p.Asn110Lys Single submitter ⚠
- p.Asn17Ile Single submitter ⚠
- p.Asn17Ser Single submitter ⚠
- p.Asn286Asp Single submitter ⚠
- p.Asn310Lys Single submitter ⚠
- p.Asn364Asp Single submitter ⚠
- p.Asp221Val Single submitter ⚠
- p.Cys100Tyr Single submitter ⚠
- p.Cys371Tyr Single submitter ⚠
- p.Cys384Tyr Single submitter ⚠
- p.Gln7Arg Single submitter ⚠
- p.Gly319Asp Single submitter ⚠
- p.Gly369Arg Single submitter ⚠
- p.His184Arg Single submitter ⚠
- p.His253Tyr Single submitter ⚠
- p.Ile13Thr Single submitter ⚠
- p.Ile146Thr Single submitter ⚠
- p.Ile169Met Single submitter ⚠
- p.Ile77Val Single submitter ⚠
- p.Leu331Phe Single submitter ⚠
- p.Leu345Phe Single submitter ⚠
- p.Leu34Phe Single submitter ⚠
- p.Lys15Glu Single submitter ⚠
- p.Lys164Glu Single submitter ⚠
- p.Phe21Ser Single submitter ⚠
- p.Pro31Leu Single submitter ⚠
- p.Ser114Asn Single submitter ⚠
- p.Ser181Arg Single submitter ⚠
- p.Ser181Asn Single submitter ⚠
- p.Ser271Leu Single submitter ⚠
- p.Ser326Arg Single submitter ⚠
- p.Thr119Pro Single submitter ⚠
- p.Thr263Met Single submitter ⚠
- p.Thr307Asn Single submitter ⚠
- p.Trp353Arg Single submitter ⚠
- p.Val130Ile Single submitter ⚠
- p.Val156Leu Single submitter ⚠
- p.Val329Ile Single submitter ⚠
- p.Val83Met Single submitter ⚠