HDAC1 — 36 ClinVar variants
All ClinVar germline HDAC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
1 Likely pathogenic · 2 Benign · 2 Likely benign · 31 Uncertain significance
Full HDAC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HDAC1 p.Ala388Thr Uncertain significance Single submitter
- HDAC1 p.Arg310Gln Uncertain significance Single submitter
- HDAC1 p.Arg310Trp Uncertain significance Single submitter
- HDAC1 p.Arg413Gln Uncertain significance Single submitter
- HDAC1 p.Arg77Leu Uncertain significance Single submitter
- HDAC1 p.Asp400Asn Uncertain significance Single submitter
- HDAC1 p.Asp422Asn Uncertain significance Single submitter
- HDAC1 p.Glu461Lys Uncertain significance Single submitter
- HDAC1 p.Gly115Asp Uncertain significance Single submitter
- HDAC1 p.Gly180Asp Uncertain significance Single submitter
- HDAC1 p.Gly202Ala Uncertain significance Single submitter
- HDAC1 p.Lys165Arg Uncertain significance Single submitter
- HDAC1 p.Lys403Arg Uncertain significance Single submitter
- HDAC1 p.Ser85Thr Uncertain significance Single submitter
- HDAC1 p.Tyr237Cys Uncertain significance Single submitter
- HDAC1 p.Tyr333Cys Uncertain significance Single submitter
- HDAC1 p.Val157Ile Uncertain significance Single submitter
- HDAC1 p.Val193Ile Uncertain significance Single submitter
- HDAC1 p.Val443Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- HDAC1 p.Ala256Thr Uncertain significance Single submitter
- HDAC1 p.Asp395Asn Uncertain significance Single submitter
- HDAC1 p.Asp397Asn Uncertain significance Single submitter
- HDAC1 p.Glu478Val Uncertain significance Single submitter
- HDAC1 p.Ile173Leu Uncertain significance Single submitter
- HDAC1 p.Lys432Thr Uncertain significance Single submitter
- HDAC1 p.Lys456Glu Uncertain significance Single submitter
- HDAC1 p.Lys473Arg Uncertain significance Single submitter
- HDAC1 p.Pro390His Uncertain significance Single submitter
- HDAC1 p.Ser290Cys Uncertain significance Single submitter
- HDAC1 p.Tyr237Phe Uncertain significance Single submitter
All HDAC1 variants
Likely pathogenic 1
- p.Asn154Ser Single submitter Inborn genetic diseases
Uncertain significance 31
- p.Ala256Thr Single submitter ⚠
- p.Ala388Thr Single submitter ⚠
- p.Arg310Gln Single submitter ⚠
- p.Arg310Trp Single submitter ⚠
- p.Arg413Gln Single submitter ⚠
- p.Arg77Leu Single submitter ⚠
- p.Asp18fs Single submitter
- p.Asp395Asn Single submitter ⚠
- p.Asp397Asn Single submitter ⚠
- p.Asp400Asn Single submitter ⚠
- p.Asp422Asn Single submitter ⚠
- p.Glu461Lys Single submitter ⚠
- p.Glu478Val Single submitter ⚠
- p.Gly115Asp Single submitter ⚠
- p.Gly180Asp Single submitter ⚠
- p.Gly202Ala Single submitter ⚠
- p.Ile173Leu Single submitter ⚠
- p.Lys165Arg Single submitter ⚠
- p.Lys403Arg Single submitter ⚠
- p.Lys432Thr Single submitter ⚠
- p.Lys456Glu Single submitter ⚠
- p.Lys473Arg Single submitter ⚠
- p.Pro390His Single submitter ⚠
- p.Ser290Cys Single submitter ⚠
- p.Ser85Thr Single submitter ⚠
- p.Tyr237Cys Single submitter ⚠
- p.Tyr237Phe Single submitter ⚠
- p.Tyr333Cys Single submitter ⚠
- p.Val157Ile Single submitter ⚠
- p.Val193Ile Single submitter ⚠
- p.Val443Leu Single submitter ⚠