HDAC11 — 50 ClinVar variants
All ClinVar germline HDAC11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
4 Likely benign · 46 Uncertain significance
Full HDAC11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HDAC11 p.Ala156Ser Uncertain significance Single submitter
- HDAC11 p.Ala156Val Uncertain significance Single submitter
- HDAC11 p.Ala276Val Uncertain significance Single submitter
- HDAC11 p.Ala309Val Uncertain significance Single submitter
- HDAC11 p.Arg168Cys Uncertain significance Single submitter
- HDAC11 p.Arg213His Uncertain significance Single submitter
- HDAC11 p.Arg213Leu Uncertain significance Single submitter
- HDAC11 p.Arg221Gln Uncertain significance Single submitter
- HDAC11 p.Arg290Cys Uncertain significance Single submitter
- HDAC11 p.Arg293Trp Uncertain significance Single submitter
- HDAC11 p.Arg307Cys Uncertain significance Single submitter
- HDAC11 p.Arg310Cys Uncertain significance Single submitter
- HDAC11 p.Arg77Lys Uncertain significance Single submitter
- HDAC11 p.Asn336Ser Uncertain significance Single submitter
- HDAC11 p.Asp157Gly Uncertain significance Single submitter
- HDAC11 p.Glu226Asp Uncertain significance Single submitter
- HDAC11 p.Glu264Asp Uncertain significance Single submitter
- HDAC11 p.Gly303Arg Uncertain significance Single submitter
- HDAC11 p.Gly43Asp Uncertain significance Single submitter
- HDAC11 p.His207Arg Uncertain significance Single submitter
- HDAC11 p.His249Arg Uncertain significance Single submitter
- HDAC11 p.Leu101Phe Uncertain significance Single submitter
- HDAC11 p.Pro12Ser Uncertain significance Single submitter
- HDAC11 p.Pro17Gln Uncertain significance Single submitter
- HDAC11 p.Pro330Ala Uncertain significance Single submitter
- HDAC11 p.Pro340Leu Uncertain significance Single submitter
- HDAC11 p.Pro344Leu Uncertain significance Single submitter
- HDAC11 p.Ser315Phe Uncertain significance Single submitter
- HDAC11 p.Ser331Arg Uncertain significance Single submitter
- HDAC11 p.Thr14Ile Uncertain significance Single submitter
- HDAC11 p.Val169Met Uncertain significance Single submitter
- HDAC11 p.Val254Ala Uncertain significance Single submitter
- HDAC11 p.Val98Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- HDAC11 p.Ala124Val Uncertain significance Single submitter
- HDAC11 p.Arg197His Uncertain significance Single submitter
- HDAC11 p.Arg221Trp Uncertain significance Single submitter
- HDAC11 p.Arg267Cys Uncertain significance Single submitter
- HDAC11 p.Arg292Cys Uncertain significance Single submitter
- HDAC11 p.Asp252Asn Uncertain significance Single submitter
- HDAC11 p.Gly138Ala Uncertain significance Single submitter
- HDAC11 p.Ile200Val Uncertain significance Single submitter
- HDAC11 p.Lys50Asn Uncertain significance Single submitter
- HDAC11 p.Val137Met Uncertain significance Single submitter
All HDAC11 variants
Likely benign 4
- p.Pro343His Multiple submitters
- p.Arg293Gln Single submitter
- p.Ile178Val Single submitter
- p.Val332Ile Single submitter
Uncertain significance 46
- p.Ala124Val Single submitter ⚠
- p.Ala156Ser Single submitter ⚠
- p.Ala156Val Single submitter ⚠
- p.Ala276Val Single submitter ⚠
- p.Ala309Val Single submitter ⚠
- p.Arg168Cys Single submitter ⚠
- p.Arg197His Single submitter ⚠
- p.Arg213His Single submitter ⚠
- p.Arg213Leu Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg221Trp Single submitter ⚠
- p.Arg267Cys Single submitter ⚠
- p.Arg290Cys Single submitter ⚠
- p.Arg292Cys Single submitter ⚠
- p.Arg293Trp Single submitter ⚠
- p.Arg307Cys Single submitter ⚠
- p.Arg310Cys Single submitter ⚠
- p.Arg77Lys Single submitter ⚠
- p.Asn336Ser Single submitter ⚠
- p.Asp157Gly Single submitter ⚠
- p.Asp252Asn Single submitter ⚠
- p.Glu226Asp Single submitter ⚠
- p.Glu264Asp Single submitter ⚠
- p.Glu51Val Single submitter
- p.Gly138Ala Single submitter ⚠
- p.Gly303Arg Single submitter ⚠
- p.Gly43Asp Single submitter ⚠
- p.His207Arg Single submitter ⚠
- p.His249Arg Single submitter ⚠
- p.Ile200Val Single submitter ⚠
- p.Ile325Thr Single submitter
- p.Leu101Phe Single submitter ⚠
- p.Lys216Glu Single submitter
- p.Lys50Asn Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro17Gln Single submitter ⚠
- p.Pro330Ala Single submitter ⚠
- p.Pro340Leu Single submitter ⚠
- p.Pro344Leu Single submitter ⚠
- p.Ser315Phe Single submitter ⚠
- p.Ser331Arg Single submitter ⚠
- p.Thr14Ile Single submitter ⚠
- p.Val137Met Single submitter ⚠
- p.Val169Met Single submitter ⚠
- p.Val254Ala Single submitter ⚠
- p.Val98Ile Single submitter ⚠