HDAC5 — 148 ClinVar variants
All ClinVar germline HDAC5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 124 flagged for review →
9 Benign · 7 Likely benign · 132 Uncertain significance
Full HDAC5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 124
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 107
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HDAC5 p.Ala1065Thr Uncertain significance Single submitter
- HDAC5 p.Ala1096Thr Uncertain significance Single submitter
- HDAC5 p.Ala1112Thr Uncertain significance Single submitter
- HDAC5 p.Ala1121Val Uncertain significance Single submitter
- HDAC5 p.Ala303Thr Uncertain significance Single submitter
- HDAC5 p.Ala307Gly Uncertain significance Single submitter
- HDAC5 p.Ala314Thr Uncertain significance Single submitter
- HDAC5 p.Ala330Thr Uncertain significance Single submitter
- HDAC5 p.Ala389Asp Uncertain significance Single submitter
- HDAC5 p.Ala399Thr Uncertain significance Single submitter
- HDAC5 p.Ala442Ser Uncertain significance Single submitter
- HDAC5 p.Ala644Val Uncertain significance Single submitter
- HDAC5 p.Ala649Thr Uncertain significance Single submitter
- HDAC5 p.Arg1070Trp Uncertain significance Single submitter
- HDAC5 p.Arg1105Gln Uncertain significance Single submitter
- HDAC5 p.Arg145Gln Uncertain significance Single submitter
- HDAC5 p.Arg151Gln Uncertain significance Single submitter
- HDAC5 p.Arg22Trp Uncertain significance Single submitter
- HDAC5 p.Arg249Gln Uncertain significance Single submitter
- HDAC5 p.Arg283Cys Uncertain significance Single submitter
- HDAC5 p.Arg284His Uncertain significance Single submitter
- HDAC5 p.Arg350Gly Uncertain significance Single submitter
- HDAC5 p.Arg408Trp Uncertain significance Single submitter
- HDAC5 p.Arg476His Uncertain significance Single submitter
- HDAC5 p.Arg573Gln Uncertain significance Single submitter
- HDAC5 p.Arg60Gln Uncertain significance Single submitter
- HDAC5 p.Asn371Asp Uncertain significance Single submitter
- HDAC5 p.Asp103Glu Uncertain significance Single submitter
- HDAC5 p.Asp247Asn Uncertain significance Single submitter
- HDAC5 p.Asp251His Uncertain significance Single submitter
- HDAC5 p.Asp600Asn Uncertain significance Single submitter
- HDAC5 p.Asp632Ala Uncertain significance Single submitter
- HDAC5 p.Gln1037Glu Uncertain significance Single submitter
- HDAC5 p.Gln128Arg Uncertain significance Single submitter
- HDAC5 p.Gln149Arg Uncertain significance Single submitter
- HDAC5 p.Gln162Arg Uncertain significance Single submitter
- HDAC5 p.Gln409Lys Uncertain significance Single submitter
- HDAC5 p.Gln453Arg Uncertain significance Single submitter
- HDAC5 p.Gln514Pro Uncertain significance Single submitter
- HDAC5 p.Gln530Lys Uncertain significance Single submitter
- HDAC5 p.Glu1052Lys Uncertain significance Single submitter
- HDAC5 p.Glu1074Asp Uncertain significance Single submitter
- HDAC5 p.Glu400Lys Uncertain significance Single submitter
- HDAC5 p.Glu561Asp Uncertain significance Single submitter
- HDAC5 p.Glu561Val Uncertain significance Single submitter
- HDAC5 p.Glu589Asp Uncertain significance Single submitter
- HDAC5 p.Glu610Lys Uncertain significance Single submitter
- HDAC5 p.Glu621Asp Uncertain significance Single submitter
- HDAC5 p.Glu819Gly Uncertain significance Single submitter
- HDAC5 p.Gly1095Glu Uncertain significance Single submitter
- HDAC5 p.Gly304Arg Uncertain significance Single submitter
- HDAC5 p.Gly440Arg Uncertain significance Single submitter
- HDAC5 p.Gly47Glu Uncertain significance Single submitter
- HDAC5 p.Gly625Val Uncertain significance Single submitter
- HDAC5 p.Gly657Ser Uncertain significance Single submitter
- HDAC5 p.Gly667Glu Uncertain significance Single submitter
- HDAC5 p.Gly722Ser Uncertain significance Single submitter
- HDAC5 p.Gly975Asp Uncertain significance Single submitter
- HDAC5 p.His748Tyr Uncertain significance Single submitter
- HDAC5 p.His796Arg Uncertain significance Single submitter
- HDAC5 p.Ile1051Val Uncertain significance Single submitter
- HDAC5 p.Ile423Val Uncertain significance Single submitter
- HDAC5 p.Ile784Met Uncertain significance Single submitter
- HDAC5 p.Ile948Val Uncertain significance Single submitter
- HDAC5 p.Leu352Phe Uncertain significance Single submitter
- HDAC5 p.Leu407Val Uncertain significance Single submitter
- HDAC5 p.Leu854Val Uncertain significance Single submitter
- HDAC5 p.Leu859Met Uncertain significance Single submitter
- HDAC5 p.Lys239Gln Uncertain significance Single submitter
- HDAC5 p.Lys486Arg Uncertain significance Single submitter
- HDAC5 p.Lys765Arg Uncertain significance Single submitter
- HDAC5 p.Met669Arg Uncertain significance Single submitter
- HDAC5 p.Met697Val Uncertain significance Single submitter
- HDAC5 p.Met775Leu Uncertain significance Single submitter
- HDAC5 p.Met946Ile Uncertain significance Single submitter
- HDAC5 p.Pro1109Ser Uncertain significance Single submitter
- HDAC5 p.Pro1111Leu Uncertain significance Single submitter
- HDAC5 p.Pro305Ala Uncertain significance Single submitter
- HDAC5 p.Pro36Leu Uncertain significance Single submitter
- HDAC5 p.Pro622Ala Uncertain significance Single submitter
- HDAC5 p.Pro666Ser Uncertain significance Single submitter
- HDAC5 p.Pro756Ser Uncertain significance Single submitter
- HDAC5 p.Pro885Ser Uncertain significance Single submitter
- HDAC5 p.Pro914Leu Uncertain significance Single submitter
- HDAC5 p.Ser1108Asn Uncertain significance Single submitter
- HDAC5 p.Ser220Ala Uncertain significance Single submitter
- HDAC5 p.Ser237Cys Uncertain significance Single submitter
- HDAC5 p.Ser647Asn Uncertain significance Single submitter
- HDAC5 p.Ser772Asn Uncertain significance Single submitter
- HDAC5 p.Ser799Arg Uncertain significance Single submitter
- HDAC5 p.Ser799Gly Uncertain significance Single submitter
- HDAC5 p.Thr343Ile Uncertain significance Single submitter
- HDAC5 p.Thr379Met Uncertain significance Single submitter
- HDAC5 p.Thr479Ile Uncertain significance Single submitter
- HDAC5 p.Thr483Met Uncertain significance Single submitter
- HDAC5 p.Thr650Ile Uncertain significance Single submitter
- HDAC5 p.Thr754Ile Uncertain significance Single submitter
- HDAC5 p.Val1025Ala Uncertain significance Single submitter
- HDAC5 p.Val1050Ile Uncertain significance Single submitter
- HDAC5 p.Val310Met Uncertain significance Single submitter
- HDAC5 p.Val380Ala Uncertain significance Single submitter
- HDAC5 p.Val430Met Uncertain significance Single submitter
- HDAC5 p.Val64Met Uncertain significance Single submitter
- HDAC5 p.Val791Ala Uncertain significance Single submitter
- HDAC5 p.Val791Met Uncertain significance Single submitter
- HDAC5 p.Val916Met Uncertain significance Single submitter
- HDAC5 p.Val935Ala Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- HDAC5 p.Ala1017Thr Uncertain significance Single submitter
- HDAC5 p.Ala82Glu Uncertain significance Single submitter
- HDAC5 p.Arg151Trp Uncertain significance Single submitter
- HDAC5 p.Arg72Trp Uncertain significance Single submitter
- HDAC5 p.Gln497Lys Uncertain significance Single submitter
- HDAC5 p.Glu1114Lys Uncertain significance Single submitter
- HDAC5 p.Glu597Lys Uncertain significance Single submitter
- HDAC5 p.Gly1095Arg Uncertain significance Single submitter
- HDAC5 p.Gly318Arg Uncertain significance Single submitter
- HDAC5 p.Gly474Asp Uncertain significance Single submitter
- HDAC5 p.His447Arg Uncertain significance Single submitter
- HDAC5 p.Ile866Val Uncertain significance Single submitter
- HDAC5 p.Leu1047Val Uncertain significance Single submitter
- HDAC5 p.Leu133Met Uncertain significance Single submitter
- HDAC5 p.Leu141Arg Uncertain significance Single submitter
- HDAC5 p.Phe417Leu Uncertain significance Single submitter
- HDAC5 p.Pro885His Benign Single submitter
All HDAC5 variants
Benign 9
- c.2608-3T>C Multiple submitters
- c.3164-9C>T Multiple submitters
- p.Ala1102Val Multiple submitters
- p.Ala82= Multiple submitters
- p.Asp593Glu Multiple submitters
- p.Gly565Ala Multiple submitters
- c.527-6C>T Single submitter
- c.642-8del Single submitter
- p.Pro885His Single submitter ⚠
Likely benign 7
- p.Lys172= Multiple submitters
- c.95-5C>T Single submitter
- p.Ala62Val Single submitter
- p.Asp590Glu Single submitter
- p.Glu598= Single submitter
- p.Ser27Gly Single submitter
- p.Val686= Single submitter
Uncertain significance 132
- c.22+1436G>T Single submitter
- c.3079-1G>A Single submitter
- p.Ala1017Thr Single submitter ⚠
- p.Ala1065Thr Single submitter ⚠
- p.Ala1096Thr Single submitter ⚠
- p.Ala1112Thr Single submitter ⚠
- p.Ala1121Val Single submitter ⚠
- p.Ala303Thr Single submitter ⚠
- p.Ala307Gly Single submitter ⚠
- p.Ala314Thr Single submitter ⚠
- p.Ala330Thr Single submitter ⚠
- p.Ala389Asp Single submitter ⚠
- p.Ala399Thr Single submitter ⚠
- p.Ala442Ser Single submitter ⚠
- p.Ala644Val Single submitter ⚠
- p.Ala649Thr Single submitter ⚠
- p.Ala82Glu Single submitter ⚠
- p.Arg1070Trp Single submitter ⚠
- p.Arg1105Gln Single submitter ⚠
- p.Arg145Gln Single submitter ⚠
- p.Arg151Gln Single submitter ⚠
- p.Arg151Trp Single submitter ⚠
- p.Arg22Trp Single submitter ⚠
- p.Arg249Gln Single submitter ⚠
- p.Arg283Cys Single submitter ⚠
- p.Arg284His Single submitter ⚠
- p.Arg350Gly Single submitter ⚠
- p.Arg408Trp Single submitter ⚠
- p.Arg476Cys Single submitter
- p.Arg476His Single submitter ⚠
- p.Arg573Gln Single submitter ⚠
- p.Arg60Gln Single submitter ⚠
- p.Arg72Trp Single submitter ⚠
- p.Asn371Asp Single submitter ⚠
- p.Asp103Glu Single submitter ⚠
- p.Asp247Asn Single submitter ⚠
- p.Asp250fs Single submitter Developmental disorder
- p.Asp251His Single submitter ⚠
- p.Asp600Asn Single submitter ⚠
- p.Asp632Ala Single submitter ⚠
- p.Asp929Tyr Single submitter
- p.Gln1037Glu Single submitter ⚠
- p.Gln128Arg Single submitter ⚠
- p.Gln149Arg Single submitter ⚠
- p.Gln162Arg Single submitter ⚠
- p.Gln409Lys Single submitter ⚠
- p.Gln453Arg Single submitter ⚠
- p.Gln497Lys Single submitter ⚠
- p.Gln514Pro Single submitter ⚠
- p.Gln530Lys Single submitter ⚠
- p.Glu1052Lys Single submitter ⚠
- p.Glu1074Asp Single submitter ⚠
- p.Glu1114Lys Single submitter ⚠
- p.Glu400Lys Single submitter ⚠
- p.Glu561Asp Single submitter ⚠
- p.Glu561Val Single submitter ⚠
- p.Glu589Asp Single submitter ⚠
- p.Glu597Lys Single submitter ⚠
- p.Glu610Lys Single submitter ⚠
- p.Glu621Asp Single submitter ⚠
- p.Glu819Gly Single submitter ⚠
- p.Gly1095Arg Single submitter ⚠
- p.Gly1095Glu Single submitter ⚠
- p.Gly304Arg Single submitter ⚠
- p.Gly318Arg Single submitter ⚠
- p.Gly333Val Single submitter
- p.Gly440Arg Single submitter ⚠
- p.Gly474Asp Single submitter ⚠
- p.Gly47Glu Single submitter ⚠
- p.Gly625Val Single submitter ⚠
- p.Gly657Ser Single submitter ⚠
- p.Gly667Glu Single submitter ⚠
- p.Gly722Ser Single submitter ⚠
- p.Gly975Asp Single submitter ⚠
- p.His447Arg Single submitter ⚠
- p.His748Tyr Single submitter ⚠
- p.His796Arg Single submitter ⚠
- p.Ile1051Val Single submitter ⚠
- p.Ile423Val Single submitter ⚠
- p.Ile784Met Single submitter ⚠
- p.Ile866Val Single submitter ⚠
- p.Ile948Val Single submitter ⚠
- p.Leu1047Val Single submitter ⚠
- p.Leu133Met Single submitter ⚠
- p.Leu141Arg Single submitter ⚠
- p.Leu352Phe Single submitter ⚠
- p.Leu407Val Single submitter ⚠
- p.Leu465Pro Single submitter
- p.Leu854Val Single submitter ⚠
- p.Leu859Met Single submitter ⚠
- p.Lys239Gln Single submitter ⚠
- p.Lys486Arg Single submitter ⚠
- p.Lys765Arg Single submitter ⚠
- p.Met669Arg Single submitter ⚠
- p.Met697Val Single submitter ⚠
- p.Met775Leu Single submitter ⚠
- p.Met946Ile Single submitter ⚠
- p.Phe417Leu Single submitter ⚠
- p.Pro1109Ser Single submitter ⚠
- p.Pro1111Leu Single submitter ⚠
- p.Pro305Ala Single submitter ⚠
- p.Pro36Leu Single submitter ⚠
- p.Pro622Ala Single submitter ⚠
- p.Pro666Ser Single submitter ⚠
- p.Pro756Ala Single submitter
- p.Pro756Ser Single submitter ⚠
- p.Pro885Ser Single submitter ⚠
- p.Pro914Leu Single submitter ⚠
- p.Ser1108Asn Single submitter ⚠
- p.Ser220Ala Single submitter ⚠
- p.Ser237Cys Single submitter ⚠
- p.Ser647Asn Single submitter ⚠
- p.Ser772Asn Single submitter ⚠
- p.Ser799Arg Single submitter ⚠
- p.Ser799Gly Single submitter ⚠
- p.Thr1046fs Single submitter Developmental disorder
- p.Thr343Ile Single submitter ⚠
- p.Thr379Met Single submitter ⚠
- p.Thr479Ile Single submitter ⚠
- p.Thr483Met Single submitter ⚠
- p.Thr650Ile Single submitter ⚠
- p.Thr754Ile Single submitter ⚠
- p.Val1025Ala Single submitter ⚠
- p.Val1050Ile Single submitter ⚠
- p.Val310Met Single submitter ⚠
- p.Val380Ala Single submitter ⚠
- p.Val430Met Single submitter ⚠
- p.Val64Met Single submitter ⚠
- p.Val791Ala Single submitter ⚠
- p.Val791Met Single submitter ⚠
- p.Val916Met Single submitter ⚠
- p.Val935Ala Single submitter ⚠