HDGF — 32 ClinVar variants
All ClinVar germline HDGF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Likely benign · 31 Uncertain significance
Full HDGF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HDGF p.Ala153Gly Uncertain significance Single submitter
- HDGF p.Ala153Val Uncertain significance Single submitter
- HDGF p.Arg208Gln Uncertain significance Single submitter
- HDGF p.Arg208Gly Uncertain significance Single submitter
- HDGF p.Arg208Trp Uncertain significance Single submitter
- HDGF p.Asn174Tyr Uncertain significance Single submitter
- HDGF p.Asp164Asn Uncertain significance Single submitter
- HDGF p.Asp62Asn Uncertain significance Single submitter
- HDGF p.Cys108Ser Uncertain significance Single submitter
- HDGF p.Gln212Arg Uncertain significance Single submitter
- HDGF p.Glu171Ala Uncertain significance Single submitter
- HDGF p.Glu178Val Uncertain significance Single submitter
- HDGF p.Glu216Lys Uncertain significance Single submitter
- HDGF p.Glu84Lys Uncertain significance Single submitter
- HDGF p.Gly123Arg Uncertain significance Single submitter
- HDGF p.Gly51Arg Uncertain significance Single submitter
- HDGF p.His237Tyr Uncertain significance Single submitter
- HDGF p.Leu162Met Uncertain significance Single submitter
- HDGF p.Leu191Phe Uncertain significance Single submitter
- HDGF p.Lys105Gln Uncertain significance Single submitter
- HDGF p.Lys170Arg Uncertain significance Single submitter
- HDGF p.Pro190Arg Uncertain significance Single submitter
- HDGF p.Pro211Leu Uncertain significance Single submitter
- HDGF p.Ser103Phe Uncertain significance Single submitter
- HDGF p.Ser239Gly Uncertain significance Single submitter
- HDGF p.Val140Ile Uncertain significance Single submitter
- HDGF p.Val195Met Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All HDGF variants
Likely benign 1
- p.His44Gln Single submitter
Uncertain significance 31
- p.Ala153Gly Single submitter ⚠
- p.Ala153Val Single submitter ⚠
- p.Arg208Gln Single submitter ⚠
- p.Arg208Gly Single submitter ⚠
- p.Arg208Trp Single submitter ⚠
- p.Asn174Tyr Single submitter ⚠
- p.Asn43Lys Single submitter ⚠
- p.Asp164Asn Single submitter ⚠
- p.Asp62Asn Single submitter ⚠
- p.Cys108Ser Single submitter ⚠
- p.Gln212Arg Single submitter ⚠
- p.Glu171Ala Single submitter ⚠
- p.Glu178Val Single submitter ⚠
- p.Glu216Lys Single submitter ⚠
- p.Glu84Lys Single submitter ⚠
- p.Gly123Arg Single submitter ⚠
- p.Gly51Arg Single submitter ⚠
- p.His237Tyr Single submitter ⚠
- p.Leu162Met Single submitter ⚠
- p.Leu191Phe Single submitter ⚠
- p.Lys105Gln Single submitter ⚠
- p.Lys170Arg Single submitter ⚠
- p.Pro190Arg Single submitter ⚠
- p.Pro211Leu Single submitter ⚠
- p.Ser103Phe Single submitter ⚠
- p.Ser239Gly Single submitter ⚠
- p.Tyr100Cys Single submitter ⚠
- p.Val140Ile Single submitter ⚠
- p.Val140Phe Single submitter ⚠
- p.Val195Met Single submitter ⚠
- p.Val95Ile Single submitter ⚠