Sugi Variant

Sugi Variant/HGF

HGF — 325 ClinVar variants

All ClinVar germline HGF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 134 flagged for review →

6 Pathogenic · 1 Pathogenic/Likely pathogenic · 2 Likely pathogenic · 8 Conflicting · 33 Benign · 6 Benign/Likely benign · 120 Likely benign · 149 Uncertain significance

Full HGF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 134

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predicted LoF vs a conflicting call 1

ClinVar submitters conflict, and it's a predicted loss-of-function change in a gene where LoF causes disease — flagged for review, not resolved (verify NMD-escape for C-terminal truncations). Non-missense.

Predictors lean, ClinVar uncertain 108

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 22

The independent predictors disagree with each other — read with care.

All HGF variants

Pathogenic 6

Pathogenic/Likely pathogenic 1

Likely pathogenic 2

Conflicting classifications of pathogenicity 8

Benign 33

Benign/Likely benign 6

Likely benign 120

Uncertain significance 149