HIPK1 — 118 ClinVar variants
All ClinVar germline HIPK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →
5 Likely benign · 113 Uncertain significance
Full HIPK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 109
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 101
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HIPK1 p.Ala1015Thr Uncertain significance Single submitter
- HIPK1 p.Ala1054Val Uncertain significance Single submitter
- HIPK1 p.Ala1075Thr Uncertain significance Single submitter
- HIPK1 p.Ala1109Ser Uncertain significance Single submitter
- HIPK1 p.Ala21Val Uncertain significance Single submitter
- HIPK1 p.Ala383Val Uncertain significance Single submitter
- HIPK1 p.Ala658Gly Uncertain significance Single submitter
- HIPK1 p.Ala658Val Uncertain significance Single submitter
- HIPK1 p.Ala733Gly Uncertain significance Single submitter
- HIPK1 p.Ala737Val Uncertain significance Single submitter
- HIPK1 p.Ala743Pro Uncertain significance Single submitter
- HIPK1 p.Ala744Thr Uncertain significance Single submitter
- HIPK1 p.Ala778Thr Uncertain significance Single submitter
- HIPK1 p.Arg1032Gln Uncertain significance Single submitter
- HIPK1 p.Arg1035Cys Uncertain significance Single submitter
- HIPK1 p.Arg1035His Uncertain significance Single submitter
- HIPK1 p.Arg1068Cys Uncertain significance Single submitter
- HIPK1 p.Arg1189Gln Uncertain significance Single submitter
- HIPK1 p.Arg356His Uncertain significance Single submitter
- HIPK1 p.Arg438Lys Uncertain significance Single submitter
- HIPK1 p.Arg457Gln Uncertain significance Single submitter
- HIPK1 p.Arg962Gln Uncertain significance Single submitter
- HIPK1 p.Arg983Cys Uncertain significance Single submitter
- HIPK1 p.Asn1009Asp Uncertain significance Single submitter
- HIPK1 p.Asn1009Thr Uncertain significance Single submitter
- HIPK1 p.Asn1009Tyr Uncertain significance Single submitter
- HIPK1 p.Asn1045Ser Uncertain significance Single submitter
- HIPK1 p.Asn1049Ser Uncertain significance Single submitter
- HIPK1 p.Asn514His Uncertain significance Single submitter
- HIPK1 p.Asn514Ser Uncertain significance Single submitter
- HIPK1 p.Asn57Ser Uncertain significance Single submitter
- HIPK1 p.Asn678Ser Uncertain significance Single submitter
- HIPK1 p.Asn846His Uncertain significance Single submitter
- HIPK1 p.Asp40Gly Uncertain significance Single submitter
- HIPK1 p.Asp888Asn Uncertain significance Single submitter
- HIPK1 p.Cys1025Arg Uncertain significance Single submitter
- HIPK1 p.Cys349Arg Uncertain significance Single submitter
- HIPK1 p.Gln119Lys Uncertain significance Single submitter
- HIPK1 p.Gln613Arg Uncertain significance Single submitter
- HIPK1 p.Gln685Pro Uncertain significance Single submitter
- HIPK1 p.Gln690Pro Uncertain significance Single submitter
- HIPK1 p.Gln848Arg Uncertain significance Single submitter
- HIPK1 p.Gly1036Arg Uncertain significance Single submitter
- HIPK1 p.Gly1036Glu Uncertain significance Single submitter
- HIPK1 p.Gly1186Val Uncertain significance Single submitter
- HIPK1 p.Gly73Val Uncertain significance Single submitter
- HIPK1 p.Gly785Glu Uncertain significance Single submitter
- HIPK1 p.His1141Tyr Uncertain significance Single submitter
- HIPK1 p.His180Arg Uncertain significance Single submitter
- HIPK1 p.His180Gln Uncertain significance Single submitter
- HIPK1 p.Ile1185Thr Uncertain significance Single submitter
- HIPK1 p.Ile26Thr Uncertain significance Single submitter
- HIPK1 p.Ile682Phe Uncertain significance Single submitter
- HIPK1 p.Leu1046Val Uncertain significance Single submitter
- HIPK1 p.Leu1111Val Uncertain significance Single submitter
- HIPK1 p.Leu114Phe Uncertain significance Single submitter
- HIPK1 p.Leu1165Phe Uncertain significance Single submitter
- HIPK1 p.Leu513Pro Uncertain significance Single submitter
- HIPK1 p.Leu858Pro Uncertain significance Single submitter
- HIPK1 p.Leu949Val Uncertain significance Single submitter
- HIPK1 p.Met322Thr Uncertain significance Single submitter
- HIPK1 p.Met375Ile Uncertain significance Single submitter
- HIPK1 p.Pro1100Leu Uncertain significance Single submitter
- HIPK1 p.Pro11Ala Uncertain significance Single submitter
- HIPK1 p.Pro862Ala Uncertain significance Single submitter
- HIPK1 p.Ser102Asn Uncertain significance Single submitter
- HIPK1 p.Ser1058Leu Uncertain significance Single submitter
- HIPK1 p.Ser1078Pro Uncertain significance Single submitter
- HIPK1 p.Ser1088Asn Uncertain significance Single submitter
- HIPK1 p.Ser1125Pro Uncertain significance Single submitter
- HIPK1 p.Ser1127Gly Uncertain significance Single submitter
- HIPK1 p.Ser1167Thr Uncertain significance Single submitter
- HIPK1 p.Ser1169Gly Uncertain significance Single submitter
- HIPK1 p.Ser1169Thr Uncertain significance Single submitter
- HIPK1 p.Ser14Leu Uncertain significance Single submitter
- HIPK1 p.Ser167Asn Uncertain significance Single submitter
- HIPK1 p.Ser38Ile Uncertain significance Single submitter
- HIPK1 p.Ser576Asn Uncertain significance Single submitter
- HIPK1 p.Ser601Cys Uncertain significance Single submitter
- HIPK1 p.Ser730Thr Uncertain significance Single submitter
- HIPK1 p.Ser882Phe Uncertain significance Single submitter
- HIPK1 p.Ser931Thr Uncertain significance Single submitter
- HIPK1 p.Ser948Cys Uncertain significance Single submitter
- HIPK1 p.Ser9Leu Uncertain significance Single submitter
- HIPK1 p.Thr1113Met Uncertain significance Single submitter
- HIPK1 p.Thr1146Ile Uncertain significance Single submitter
- HIPK1 p.Thr1146Ser Uncertain significance Single submitter
- HIPK1 p.Thr351Ala Uncertain significance Single submitter
- HIPK1 p.Thr512Ile Uncertain significance Single submitter
- HIPK1 p.Thr599Pro Uncertain significance Single submitter
- HIPK1 p.Thr643Ser Uncertain significance Single submitter
- HIPK1 p.Thr955Ile Uncertain significance Single submitter
- HIPK1 p.Thr99Ala Uncertain significance Single submitter
- HIPK1 p.Tyr1207Cys Uncertain significance Single submitter
- HIPK1 p.Tyr880Cys Uncertain significance Single submitter
- HIPK1 p.Tyr936Cys Uncertain significance Single submitter
- HIPK1 p.Val1014Ala Uncertain significance Single submitter
- HIPK1 p.Val13Ala Uncertain significance Single submitter
- HIPK1 p.Val632Leu Uncertain significance Single submitter
- HIPK1 p.Val716Ile Uncertain significance Single submitter
- HIPK1 p.Val739Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- HIPK1 p.His528Arg Uncertain significance Single submitter
- HIPK1 p.Leu609Pro Uncertain significance Single submitter
- HIPK1 p.Lys283Arg Uncertain significance Single submitter
- HIPK1 p.Met467Ile Uncertain significance Single submitter
- HIPK1 p.Pro1043Leu Uncertain significance Single submitter
- HIPK1 p.Pro750His Uncertain significance Single submitter
- HIPK1 p.Ser730Arg Uncertain significance Single submitter
- HIPK1 p.Trp793Cys Uncertain significance Single submitter
All HIPK1 variants
Likely benign 5
- p.Met779Val Single submitter
- p.Thr1083Ala Single submitter
- p.Thr1192Ala Single submitter
- p.Thr667Ala Single submitter
- p.Thr980Ala Single submitter
Uncertain significance 113
- p.Ala1015Thr Single submitter ⚠
- p.Ala1054Val Single submitter ⚠
- p.Ala1075Thr Single submitter ⚠
- p.Ala1109Ser Single submitter ⚠
- p.Ala21Val Single submitter ⚠
- p.Ala383Val Single submitter ⚠
- p.Ala658Gly Single submitter ⚠
- p.Ala658Val Single submitter ⚠
- p.Ala733Gly Single submitter ⚠
- p.Ala737Val Single submitter ⚠
- p.Ala743Pro Single submitter ⚠
- p.Ala744Thr Single submitter ⚠
- p.Ala778Thr Single submitter ⚠
- p.Arg1032Gln Single submitter ⚠
- p.Arg1035Cys Single submitter ⚠
- p.Arg1035His Single submitter ⚠
- p.Arg1068Cys Single submitter ⚠
- p.Arg1189Gln Single submitter ⚠
- p.Arg328His Single submitter
- p.Arg356His Single submitter ⚠
- p.Arg438Lys Single submitter ⚠
- p.Arg457Gln Single submitter ⚠
- p.Arg962Gln Single submitter ⚠
- p.Arg983Cys Single submitter ⚠
- p.Asn1009Asp Single submitter ⚠
- p.Asn1009Thr Single submitter ⚠
- p.Asn1009Tyr Single submitter ⚠
- p.Asn1045Ser Single submitter ⚠
- p.Asn1049Ser Single submitter ⚠
- p.Asn514His Single submitter ⚠
- p.Asn514Ser Single submitter ⚠
- p.Asn57Ser Single submitter ⚠
- p.Asn678Ser Single submitter ⚠
- p.Asn846His Single submitter ⚠
- p.Asp40Gly Single submitter ⚠
- p.Asp888Asn Single submitter ⚠
- p.Cys1025Arg Single submitter ⚠
- p.Cys349Arg Single submitter ⚠
- p.Gln119Lys Single submitter ⚠
- p.Gln613Arg Single submitter ⚠
- p.Gln685Pro Single submitter ⚠
- p.Gln690Pro Single submitter ⚠
- p.Gln848Arg Single submitter ⚠
- p.Gly1036Arg Single submitter ⚠
- p.Gly1036Glu Single submitter ⚠
- p.Gly1186Val Single submitter ⚠
- p.Gly73Val Single submitter ⚠
- p.Gly785Glu Single submitter ⚠
- p.His1131Arg Single submitter
- p.His1141Tyr Single submitter ⚠
- p.His180Arg Single submitter ⚠
- p.His180Gln Single submitter ⚠
- p.His528Arg Single submitter ⚠
- p.Ile1185Thr Single submitter ⚠
- p.Ile26Thr Single submitter ⚠
- p.Ile682Phe Single submitter ⚠
- p.Leu1046Val Single submitter ⚠
- p.Leu1111Val Single submitter ⚠
- p.Leu114Phe Single submitter ⚠
- p.Leu1165Phe Single submitter ⚠
- p.Leu513Pro Single submitter ⚠
- p.Leu609Pro Single submitter ⚠
- p.Leu858Pro Single submitter ⚠
- p.Leu949Val Single submitter ⚠
- p.Lys283Arg Single submitter ⚠
- p.Met322Thr Single submitter ⚠
- p.Met375Ile Single submitter ⚠
- p.Met467Ile Single submitter ⚠
- p.Pro1043Leu Single submitter ⚠
- p.Pro1100Leu Single submitter ⚠
- p.Pro11Ala Single submitter ⚠
- p.Pro750His Single submitter ⚠
- p.Pro862Ala Single submitter ⚠
- p.Ser102Asn Single submitter ⚠
- p.Ser1058Leu Single submitter ⚠
- p.Ser1078Pro Single submitter ⚠
- p.Ser1088Asn Single submitter ⚠
- p.Ser1125Pro Single submitter ⚠
- p.Ser1127Gly Single submitter ⚠
- p.Ser1167Thr Single submitter ⚠
- p.Ser1169Gly Single submitter ⚠
- p.Ser1169Thr Single submitter ⚠
- p.Ser14Leu Single submitter ⚠
- p.Ser167Asn Single submitter ⚠
- p.Ser38Ile Single submitter ⚠
- p.Ser576Asn Single submitter ⚠
- p.Ser601Cys Single submitter ⚠
- p.Ser730Arg Single submitter ⚠
- p.Ser730Thr Single submitter ⚠
- p.Ser882Phe Single submitter ⚠
- p.Ser931Thr Single submitter ⚠
- p.Ser948Cys Single submitter ⚠
- p.Ser9Leu Single submitter ⚠
- p.Thr1113Met Single submitter ⚠
- p.Thr1146Ile Single submitter ⚠
- p.Thr1146Ser Single submitter ⚠
- p.Thr351Ala Single submitter ⚠
- p.Thr512Ile Single submitter ⚠
- p.Thr599Pro Single submitter ⚠
- p.Thr643Ser Single submitter ⚠
- p.Thr955Ile Single submitter ⚠
- p.Thr99Ala Single submitter ⚠
- p.Trp793Cys Single submitter ⚠
- p.Tyr1207Cys Single submitter ⚠
- p.Tyr249His Single submitter
- p.Tyr459Phe Single submitter
- p.Tyr880Cys Single submitter ⚠
- p.Tyr936Cys Single submitter ⚠
- p.Val1014Ala Single submitter ⚠
- p.Val13Ala Single submitter ⚠
- p.Val632Leu Single submitter ⚠
- p.Val716Ile Single submitter ⚠
- p.Val739Ile Single submitter ⚠