HIPK2 — 42 ClinVar variants
All ClinVar germline HIPK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
7 Likely benign · 35 Uncertain significance
Full HIPK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HIPK2 p.Ala226Val Uncertain significance Single submitter
- HIPK2 p.Ala311Thr Uncertain significance Single submitter
- HIPK2 p.Ala323Pro Uncertain significance Single submitter
- HIPK2 p.Ala667Val Uncertain significance Single submitter
- HIPK2 p.Ala735Val Uncertain significance Single submitter
- HIPK2 p.Ala743Val Uncertain significance Single submitter
- HIPK2 p.Arg302Ser Uncertain significance Single submitter
- HIPK2 p.Arg447Ile Uncertain significance Single submitter
- HIPK2 p.Asn113Ser Uncertain significance Single submitter
- HIPK2 p.Asp257Gly Uncertain significance Single submitter
- HIPK2 p.Cys26Ser Uncertain significance Single submitter
- HIPK2 p.Gln13Glu Uncertain significance Single submitter
- HIPK2 p.Gln338Arg Uncertain significance Single submitter
- HIPK2 p.Gln61His Uncertain significance Single submitter
- HIPK2 p.Gly109Ser Uncertain significance Single submitter
- HIPK2 p.His92Asn Uncertain significance Single submitter
- HIPK2 p.Ile84Thr Uncertain significance Single submitter
- HIPK2 p.Leu504Phe Uncertain significance Single submitter
- HIPK2 p.Met582Leu Uncertain significance Single submitter
- HIPK2 p.Pro518Ser Uncertain significance Single submitter
- HIPK2 p.Thr19Ile Uncertain significance Single submitter
- HIPK2 p.Thr583Asn Uncertain significance Single submitter
- HIPK2 p.Tyr468Ser Uncertain significance Single submitter
- HIPK2 p.Val85Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- HIPK2 p.Ala248Val Uncertain significance Single submitter
- HIPK2 p.Ala512Thr Uncertain significance Single submitter
- HIPK2 p.Ala628Thr Uncertain significance Single submitter
- HIPK2 p.Asp511Asn Uncertain significance Single submitter
- HIPK2 p.Glu139Lys Uncertain significance Single submitter
- HIPK2 p.Glu486Gly Uncertain significance Single submitter
- HIPK2 p.Lys134Arg Uncertain significance Single submitter
- HIPK2 p.Ser178Phe Uncertain significance Single submitter
- HIPK2 p.Ser77Arg Uncertain significance Single submitter
- HIPK2 p.Thr162Ile Uncertain significance Single submitter
- HIPK2 p.Thr64Asn Uncertain significance Single submitter
All HIPK2 variants
Likely benign 7
Uncertain significance 35
- p.Ala226Val Single submitter ⚠
- p.Ala248Val Single submitter ⚠
- p.Ala311Thr Single submitter ⚠
- p.Ala323Pro Single submitter ⚠
- p.Ala512Thr Single submitter ⚠
- p.Ala628Thr Single submitter ⚠
- p.Ala667Val Single submitter ⚠
- p.Ala735Val Single submitter ⚠
- p.Ala743Val Single submitter ⚠
- p.Arg302Ser Single submitter ⚠
- p.Arg447Ile Single submitter ⚠
- p.Asn113Ser Single submitter ⚠
- p.Asp257Gly Single submitter ⚠
- p.Asp511Asn Single submitter ⚠
- p.Cys26Ser Single submitter ⚠
- p.Gln13Glu Single submitter ⚠
- p.Gln338Arg Single submitter ⚠
- p.Gln61His Single submitter ⚠
- p.Glu139Lys Single submitter ⚠
- p.Glu486Gly Single submitter ⚠
- p.Gly109Ser Single submitter ⚠
- p.His92Asn Single submitter ⚠
- p.Ile84Thr Single submitter ⚠
- p.Leu504Phe Single submitter ⚠
- p.Lys134Arg Single submitter ⚠
- p.Met582Leu Single submitter ⚠
- p.Pro518Ser Single submitter ⚠
- p.Ser178Phe Single submitter ⚠
- p.Ser77Arg Single submitter ⚠
- p.Thr162Ile Single submitter ⚠
- p.Thr19Ile Single submitter ⚠
- p.Thr583Asn Single submitter ⚠
- p.Thr64Asn Single submitter ⚠
- p.Tyr468Ser Single submitter ⚠
- p.Val85Ala Single submitter ⚠