HIPK4 — 108 ClinVar variants
All ClinVar germline HIPK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 94 flagged for review →
1 Likely pathogenic · 4 Benign · 8 Likely benign · 95 Uncertain significance
Full HIPK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 94
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 82
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HIPK4 p.Ala242Asp Uncertain significance Single submitter
- HIPK4 p.Ala300Asp Uncertain significance Single submitter
- HIPK4 p.Ala385Pro Uncertain significance Single submitter
- HIPK4 p.Ala385Val Uncertain significance Single submitter
- HIPK4 p.Ala476Pro Uncertain significance Single submitter
- HIPK4 p.Ala493Val Uncertain significance Single submitter
- HIPK4 p.Ala82Val Uncertain significance Single submitter
- HIPK4 p.Arg114His Uncertain significance Single submitter
- HIPK4 p.Arg126Trp Uncertain significance Single submitter
- HIPK4 p.Arg276His Uncertain significance Single submitter
- HIPK4 p.Arg280His Uncertain significance Single submitter
- HIPK4 p.Arg281Cys Uncertain significance Single submitter
- HIPK4 p.Arg281His Uncertain significance Single submitter
- HIPK4 p.Arg302Trp Uncertain significance Single submitter
- HIPK4 p.Arg308Trp Uncertain significance Single submitter
- HIPK4 p.Arg31Gln Uncertain significance Single submitter
- HIPK4 p.Arg326Cys Uncertain significance Single submitter
- HIPK4 p.Arg353His Uncertain significance Single submitter
- HIPK4 p.Arg367Cys Uncertain significance Single submitter
- HIPK4 p.Arg367His Uncertain significance Single submitter
- HIPK4 p.Arg415Gln Uncertain significance Single submitter
- HIPK4 p.Arg481Cys Uncertain significance Single submitter
- HIPK4 p.Arg481His Uncertain significance Single submitter
- HIPK4 p.Arg485His Uncertain significance Single submitter
- HIPK4 p.Arg50His Uncertain significance Single submitter
- HIPK4 p.Arg50Leu Uncertain significance Single submitter
- HIPK4 p.Arg594Cys Uncertain significance Single submitter
- HIPK4 p.Arg595Cys Uncertain significance Single submitter
- HIPK4 p.Arg74His Uncertain significance Single submitter
- HIPK4 p.Asn104Lys Uncertain significance Single submitter
- HIPK4 p.Asn448Ser Uncertain significance Single submitter
- HIPK4 p.Asp316Asn Uncertain significance Single submitter
- HIPK4 p.Asp430His Uncertain significance Single submitter
- HIPK4 p.Asp544Ala Uncertain significance Single submitter
- HIPK4 p.Asp544Gly Uncertain significance Single submitter
- HIPK4 p.Cys10Ser Uncertain significance Single submitter
- HIPK4 p.Cys243Trp Uncertain significance Single submitter
- HIPK4 p.Glu15Lys Uncertain significance Single submitter
- HIPK4 p.Glu194Lys Uncertain significance Single submitter
- HIPK4 p.Glu357Lys Uncertain significance Single submitter
- HIPK4 p.Glu398Asp Uncertain significance Single submitter
- HIPK4 p.Glu444Lys Uncertain significance Single submitter
- HIPK4 p.Glu534Val Uncertain significance Single submitter
- HIPK4 p.Gly530Arg Uncertain significance Single submitter
- HIPK4 p.Gly614Arg Uncertain significance Single submitter
- HIPK4 p.Gly64Asp Uncertain significance Single submitter
- HIPK4 p.His246Gln Uncertain significance Single submitter
- HIPK4 p.His314Tyr Uncertain significance Single submitter
- HIPK4 p.His599Gln Uncertain significance Single submitter
- HIPK4 p.His60Tyr Uncertain significance Single submitter
- HIPK4 p.Ile164Val Uncertain significance Single submitter
- HIPK4 p.Ile41Met Uncertain significance Single submitter
- HIPK4 p.Ile548Val Uncertain significance Single submitter
- HIPK4 p.Leu278Ser Uncertain significance Single submitter
- HIPK4 p.Leu457Phe Uncertain significance Single submitter
- HIPK4 p.Leu457Pro Uncertain significance Single submitter
- HIPK4 p.Leu536Arg Uncertain significance Single submitter
- HIPK4 p.Leu65Val Uncertain significance Single submitter
- HIPK4 p.Leu76Pro Uncertain significance Single submitter
- HIPK4 p.Leu96Phe Uncertain significance Single submitter
- HIPK4 p.Lys84Arg Uncertain significance Single submitter
- HIPK4 p.Met553Val Uncertain significance Single submitter
- HIPK4 p.Phe192Val Uncertain significance Single submitter
- HIPK4 p.Phe78Val Uncertain significance Single submitter
- HIPK4 p.Pro139Leu Uncertain significance Single submitter
- HIPK4 p.Pro236Ala Uncertain significance Single submitter
- HIPK4 p.Pro253Leu Uncertain significance Single submitter
- HIPK4 p.Pro512Thr Uncertain significance Single submitter
- HIPK4 p.Pro535Ser Uncertain significance Single submitter
- HIPK4 p.Pro602Leu Uncertain significance Single submitter
- HIPK4 p.Ser266Leu Uncertain significance Single submitter
- HIPK4 p.Ser348Thr Uncertain significance Single submitter
- HIPK4 p.Ser406Asn Uncertain significance Single submitter
- HIPK4 p.Ser469Leu Uncertain significance Single submitter
- HIPK4 p.Ser480Asn Uncertain significance Single submitter
- HIPK4 p.Ser508Arg Uncertain significance Single submitter
- HIPK4 p.Thr273Met Uncertain significance Single submitter
- HIPK4 p.Thr8Ser Uncertain significance Single submitter
- HIPK4 p.Val275Leu Uncertain significance Single submitter
- HIPK4 p.Val275Met Uncertain significance Single submitter
- HIPK4 p.Val384Met Uncertain significance Single submitter
-
HIPK4 p.Asp427Asn
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 12
The independent predictors disagree with each other — read with care.
- HIPK4 p.Arg225His Uncertain significance Single submitter
- HIPK4 p.Arg280Cys Uncertain significance Single submitter
- HIPK4 p.Asp9Asn Uncertain significance Single submitter
- HIPK4 p.Cys193Arg Uncertain significance Single submitter
- HIPK4 p.Glu272Lys Uncertain significance Single submitter
- HIPK4 p.Glu35Lys Uncertain significance Single submitter
- HIPK4 p.Ile51Asn Uncertain significance Single submitter
- HIPK4 p.Met349Ile Uncertain significance Single submitter
- HIPK4 p.Met36Ile Uncertain significance Single submitter
- HIPK4 p.Ser6Leu Uncertain significance Single submitter
- HIPK4 p.Thr115Arg Uncertain significance Single submitter
- HIPK4 p.Thr230Ile Uncertain significance Single submitter
All HIPK4 variants
Likely pathogenic 1
- p.Met1Val Single submitter male infertility
Benign 4
- p.Gly421Ser Multiple submitters
- p.His344= Multiple submitters
- p.Ser406Arg Multiple submitters
- p.Thr304Ile Single submitter
Likely benign 8
- p.Ala449Val Single submitter
- p.Cys394Arg Single submitter
- p.Gly409Ser Single submitter
- p.His528Arg Single submitter
- p.Lys399Glu Single submitter
- p.Thr304Asn Single submitter
- p.Val198Met Single submitter
- p.Val583Ile Single submitter
Uncertain significance 95
- p.Ala242Asp Single submitter ⚠
- p.Ala300Asp Single submitter ⚠
- p.Ala385Pro Single submitter ⚠
- p.Ala385Val Single submitter ⚠
- p.Ala476Pro Single submitter ⚠
- p.Ala493Val Single submitter ⚠
- p.Ala82Val Single submitter ⚠
- p.Arg114His Single submitter ⚠
- p.Arg126Trp Single submitter ⚠
- p.Arg225His Single submitter ⚠
- p.Arg276His Single submitter ⚠
- p.Arg280Cys Single submitter ⚠
- p.Arg280His Single submitter ⚠
- p.Arg281Cys Single submitter ⚠
- p.Arg281His Single submitter ⚠
- p.Arg302Trp Single submitter ⚠
- p.Arg308Trp Single submitter ⚠
- p.Arg31Gln Single submitter ⚠
- p.Arg326Cys Single submitter ⚠
- p.Arg353His Single submitter ⚠
- p.Arg367Cys Single submitter ⚠
- p.Arg367His Single submitter ⚠
- p.Arg415Gln Single submitter ⚠
- p.Arg481Cys Single submitter ⚠
- p.Arg481His Single submitter ⚠
- p.Arg485His Single submitter ⚠
- p.Arg50His Single submitter ⚠
- p.Arg50Leu Single submitter ⚠
- p.Arg594Cys Single submitter ⚠
- p.Arg595Cys Single submitter ⚠
- p.Arg74His Single submitter ⚠
- p.Asn104Lys Single submitter ⚠
- p.Asn448Ser Single submitter ⚠
- p.Asp316Asn Single submitter ⚠
- p.Asp430His Single submitter ⚠
- p.Asp544Ala Single submitter ⚠
- p.Asp544Gly Single submitter ⚠
- p.Asp9Asn Single submitter ⚠
- p.Cys10Ser Single submitter ⚠
- p.Cys193Arg Single submitter ⚠
- p.Cys243Trp Single submitter ⚠
- p.Gln290His Single submitter
- p.Glu15Lys Single submitter ⚠
- p.Glu194Lys Single submitter ⚠
- p.Glu272Lys Single submitter ⚠
- p.Glu357Lys Single submitter ⚠
- p.Glu35Lys Single submitter ⚠
- p.Glu398Asp Single submitter ⚠
- p.Glu444Lys Single submitter ⚠
- p.Glu534Val Single submitter ⚠
- p.Gly530Arg Single submitter ⚠
- p.Gly614Arg Single submitter ⚠
- p.Gly64Asp Single submitter ⚠
- p.His246Gln Single submitter ⚠
- p.His314Tyr Single submitter ⚠
- p.His599Gln Single submitter ⚠
- p.His60Tyr Single submitter ⚠
- p.Ile164Val Single submitter ⚠
- p.Ile41Met Single submitter ⚠
- p.Ile51Asn Single submitter ⚠
- p.Ile548Val Single submitter ⚠
- p.Leu278Ser Single submitter ⚠
- p.Leu457Phe Single submitter ⚠
- p.Leu457Pro Single submitter ⚠
- p.Leu536Arg Single submitter ⚠
- p.Leu65Val Single submitter ⚠
- p.Leu76Pro Single submitter ⚠
- p.Leu96Phe Single submitter ⚠
- p.Lys84Arg Single submitter ⚠
- p.Met349Ile Single submitter ⚠
- p.Met36Ile Single submitter ⚠
- p.Met553Val Single submitter ⚠
- p.Phe192Val Single submitter ⚠
- p.Phe78Val Single submitter ⚠
- p.Pro139Leu Single submitter ⚠
- p.Pro236Ala Single submitter ⚠
- p.Pro253Leu Single submitter ⚠
- p.Pro512Thr Single submitter ⚠
- p.Pro535Ser Single submitter ⚠
- p.Pro602Leu Single submitter ⚠
- p.Ser266Leu Single submitter ⚠
- p.Ser348Thr Single submitter ⚠
- p.Ser406Asn Single submitter ⚠
- p.Ser469Leu Single submitter ⚠
- p.Ser480Asn Single submitter ⚠
- p.Ser508Arg Single submitter ⚠
- p.Ser6Leu Single submitter ⚠
- p.Thr115Arg Single submitter ⚠
- p.Thr230Ile Single submitter ⚠
- p.Thr273Met Single submitter ⚠
- p.Thr8Ser Single submitter ⚠
- p.Val275Leu Single submitter ⚠
- p.Val275Met Single submitter ⚠
- p.Val384Met Single submitter ⚠
- p.Asp427Asn No assertion criteria prostate cancer ⚠