HIRIP3 — 95 ClinVar variants
All ClinVar germline HIRIP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 88 flagged for review →
4 Likely benign · 91 Uncertain significance
Full HIRIP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 88
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HIRIP3 p.Ala106Val Uncertain significance Single submitter
- HIRIP3 p.Ala138Pro Uncertain significance Single submitter
- HIRIP3 p.Ala181Thr Uncertain significance Single submitter
- HIRIP3 p.Ala233Asp Uncertain significance Single submitter
- HIRIP3 p.Ala2Gly Uncertain significance Single submitter
- HIRIP3 p.Ala409Thr Uncertain significance Single submitter
- HIRIP3 p.Ala425Gly Uncertain significance Single submitter
- HIRIP3 p.Ala461Ser Uncertain significance Single submitter
- HIRIP3 p.Ala538Thr Uncertain significance Single submitter
- HIRIP3 p.Ala67Val Uncertain significance Single submitter
- HIRIP3 p.Arg12His Uncertain significance Single submitter
- HIRIP3 p.Arg418Cys Uncertain significance Single submitter
- HIRIP3 p.Arg525Gln Uncertain significance Single submitter
- HIRIP3 p.Arg526Gln Uncertain significance Single submitter
- HIRIP3 p.Arg534Trp Uncertain significance Single submitter
- HIRIP3 p.Arg546His Uncertain significance Single submitter
- HIRIP3 p.Arg69Lys Uncertain significance Single submitter
- HIRIP3 p.Asn131Lys Uncertain significance Single submitter
- HIRIP3 p.Asn384Ser Uncertain significance Single submitter
- HIRIP3 p.Asn97Thr Uncertain significance Single submitter
- HIRIP3 p.Asp144Gly Uncertain significance Single submitter
- HIRIP3 p.Asp404Asn Uncertain significance Single submitter
- HIRIP3 p.Asp64Asn Uncertain significance Single submitter
- HIRIP3 p.Gln148His Uncertain significance Single submitter
- HIRIP3 p.Gln154His Uncertain significance Single submitter
- HIRIP3 p.Gln154Pro Uncertain significance Single submitter
- HIRIP3 p.Gln295Pro Uncertain significance Single submitter
- HIRIP3 p.Gln62Arg Uncertain significance Single submitter
- HIRIP3 p.Glu130Lys Uncertain significance Single submitter
- HIRIP3 p.Glu249Lys Uncertain significance Single submitter
- HIRIP3 p.Glu252Asp Uncertain significance Single submitter
- HIRIP3 p.Glu253Lys Uncertain significance Single submitter
- HIRIP3 p.Glu273Lys Uncertain significance Single submitter
- HIRIP3 p.Glu293Lys Uncertain significance Single submitter
- HIRIP3 p.Glu337Lys Uncertain significance Single submitter
- HIRIP3 p.Glu421Val Uncertain significance Single submitter
- HIRIP3 p.Glu45Lys Uncertain significance Single submitter
- HIRIP3 p.Glu4Lys Uncertain significance Single submitter
- HIRIP3 p.Glu522Lys Uncertain significance Single submitter
- HIRIP3 p.Glu9Lys Uncertain significance Single submitter
- HIRIP3 p.Gly103Val Uncertain significance Single submitter
- HIRIP3 p.Gly156Arg Uncertain significance Single submitter
- HIRIP3 p.Gly287Arg Uncertain significance Single submitter
- HIRIP3 p.Gly306Glu Uncertain significance Single submitter
- HIRIP3 p.Gly380Glu Uncertain significance Single submitter
- HIRIP3 p.Gly405Glu Uncertain significance Single submitter
- HIRIP3 p.Gly79Asp Uncertain significance Single submitter
- HIRIP3 p.His439Tyr Uncertain significance Single submitter
- HIRIP3 p.His452Gln Uncertain significance Single submitter
- HIRIP3 p.His544Arg Uncertain significance Single submitter
- HIRIP3 p.Leu528Val Uncertain significance Single submitter
- HIRIP3 p.Leu73Pro Uncertain significance Single submitter
- HIRIP3 p.Leu75Phe Uncertain significance Single submitter
- HIRIP3 p.Lys170Asn Uncertain significance Single submitter
- HIRIP3 p.Lys179Met Uncertain significance Single submitter
- HIRIP3 p.Lys77Glu Uncertain significance Single submitter
- HIRIP3 p.Lys80Glu Uncertain significance Single submitter
- HIRIP3 p.Pro152Ser Uncertain significance Single submitter
- HIRIP3 p.Pro311Thr Uncertain significance Single submitter
- HIRIP3 p.Pro344Ala Uncertain significance Single submitter
- HIRIP3 p.Pro378Leu Uncertain significance Single submitter
- HIRIP3 p.Pro424Ala Uncertain significance Single submitter
- HIRIP3 p.Pro513Thr Uncertain significance Single submitter
- HIRIP3 p.Ser188Arg Uncertain significance Single submitter
- HIRIP3 p.Ser188Thr Uncertain significance Single submitter
- HIRIP3 p.Ser301Thr Uncertain significance Single submitter
- HIRIP3 p.Ser305Gly Uncertain significance Single submitter
- HIRIP3 p.Ser317Asn Uncertain significance Single submitter
- HIRIP3 p.Ser390Arg Uncertain significance Single submitter
- HIRIP3 p.Ser87Gly Uncertain significance Single submitter
- HIRIP3 p.Thr217Asn Uncertain significance Single submitter
- HIRIP3 p.Thr76Ile Uncertain significance Single submitter
- HIRIP3 p.Val120Leu Uncertain significance Single submitter
- HIRIP3 p.Val313Ala Uncertain significance Single submitter
- HIRIP3 p.Val490Ala Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- HIRIP3 p.Arg434Trp Uncertain significance Single submitter
- HIRIP3 p.Arg460Trp Uncertain significance Single submitter
- HIRIP3 p.Cys477Ser Uncertain significance Single submitter
- HIRIP3 p.Glu163Lys Uncertain significance Single submitter
- HIRIP3 p.Glu200Lys Uncertain significance Single submitter
- HIRIP3 p.Gly38Ser Uncertain significance Single submitter
- HIRIP3 p.Gly553Asp Uncertain significance Single submitter
- HIRIP3 p.His423Gln Uncertain significance Single submitter
- HIRIP3 p.Pro472Ser Uncertain significance Single submitter
- HIRIP3 p.Ser492Phe Uncertain significance Single submitter
- HIRIP3 p.Ser500Asn Uncertain significance Single submitter
- HIRIP3 p.Thr23Met Uncertain significance Single submitter
- HIRIP3 p.Trp511Cys Uncertain significance Single submitter
All HIRIP3 variants
Likely benign 4
- p.Arg134Gln Single submitter
- p.Asp304Asn Single submitter
- p.Asp71Glu Single submitter
- p.Gly103Ser Single submitter
Uncertain significance 91
- p.Ala106Val Single submitter ⚠
- p.Ala138Pro Single submitter ⚠
- p.Ala181Thr Single submitter ⚠
- p.Ala233Asp Single submitter ⚠
- p.Ala2Gly Single submitter ⚠
- p.Ala409Thr Single submitter ⚠
- p.Ala425Gly Single submitter ⚠
- p.Ala461Ser Single submitter ⚠
- p.Ala538Thr Single submitter ⚠
- p.Ala67Val Single submitter ⚠
- p.Arg12His Single submitter ⚠
- p.Arg418Cys Single submitter ⚠
- p.Arg434Trp Single submitter ⚠
- p.Arg460Trp Single submitter ⚠
- p.Arg478Trp Single submitter
- p.Arg506Cys Single submitter
- p.Arg525Gln Single submitter ⚠
- p.Arg526Gln Single submitter ⚠
- p.Arg534Trp Single submitter ⚠
- p.Arg546His Single submitter ⚠
- p.Arg69Lys Single submitter ⚠
- p.Asn131Lys Single submitter ⚠
- p.Asn384Ser Single submitter ⚠
- p.Asn97Thr Single submitter ⚠
- p.Asp144Gly Single submitter ⚠
- p.Asp404Asn Single submitter ⚠
- p.Asp64Asn Single submitter ⚠
- p.Cys477Ser Single submitter ⚠
- p.Gln148His Single submitter ⚠
- p.Gln154His Single submitter ⚠
- p.Gln154Pro Single submitter ⚠
- p.Gln295Pro Single submitter ⚠
- p.Gln62Arg Single submitter ⚠
- p.Glu130Lys Single submitter ⚠
- p.Glu163Lys Single submitter ⚠
- p.Glu200Lys Single submitter ⚠
- p.Glu249Lys Single submitter ⚠
- p.Glu252Asp Single submitter ⚠
- p.Glu253Lys Single submitter ⚠
- p.Glu273Lys Single submitter ⚠
- p.Glu293Lys Single submitter ⚠
- p.Glu337Lys Single submitter ⚠
- p.Glu421Val Single submitter ⚠
- p.Glu45Lys Single submitter ⚠
- p.Glu4Lys Single submitter ⚠
- p.Glu522Lys Single submitter ⚠
- p.Glu9Lys Single submitter ⚠
- p.Gly103Val Single submitter ⚠
- p.Gly156Arg Single submitter ⚠
- p.Gly287Arg Single submitter ⚠
- p.Gly306Glu Single submitter ⚠
- p.Gly380Glu Single submitter ⚠
- p.Gly38Ser Single submitter ⚠
- p.Gly405Glu Single submitter ⚠
- p.Gly553Asp Single submitter ⚠
- p.Gly79Asp Single submitter ⚠
- p.His423Gln Single submitter ⚠
- p.His439Tyr Single submitter ⚠
- p.His452Gln Single submitter ⚠
- p.His544Arg Single submitter ⚠
- p.Leu34Ter Single submitter
- p.Leu528Val Single submitter ⚠
- p.Leu73Pro Single submitter ⚠
- p.Leu75Phe Single submitter ⚠
- p.Lys170Asn Single submitter ⚠
- p.Lys179Met Single submitter ⚠
- p.Lys77Glu Single submitter ⚠
- p.Lys80Glu Single submitter ⚠
- p.Pro152Ser Single submitter ⚠
- p.Pro311Thr Single submitter ⚠
- p.Pro344Ala Single submitter ⚠
- p.Pro378Leu Single submitter ⚠
- p.Pro424Ala Single submitter ⚠
- p.Pro472Ser Single submitter ⚠
- p.Pro513Thr Single submitter ⚠
- p.Ser188Arg Single submitter ⚠
- p.Ser188Thr Single submitter ⚠
- p.Ser301Thr Single submitter ⚠
- p.Ser305Gly Single submitter ⚠
- p.Ser317Asn Single submitter ⚠
- p.Ser390Arg Single submitter ⚠
- p.Ser492Phe Single submitter ⚠
- p.Ser500Asn Single submitter ⚠
- p.Ser87Gly Single submitter ⚠
- p.Thr217Asn Single submitter ⚠
- p.Thr23Met Single submitter ⚠
- p.Thr76Ile Single submitter ⚠
- p.Trp511Cys Single submitter ⚠
- p.Val120Leu Single submitter ⚠
- p.Val313Ala Single submitter ⚠
- p.Val490Ala Single submitter ⚠