HMOX2 — 45 ClinVar variants
All ClinVar germline HMOX2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
1 Benign · 3 Likely benign · 41 Uncertain significance
Full HMOX2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HMOX2 p.Ala131Ser Uncertain significance Single submitter
- HMOX2 p.Ala208Thr Uncertain significance Single submitter
- HMOX2 p.Ala287Pro Uncertain significance Single submitter
- HMOX2 p.Ala302Val Uncertain significance Single submitter
- HMOX2 p.Ala95Ser Uncertain significance Single submitter
- HMOX2 p.Arg156Cys Uncertain significance Single submitter
- HMOX2 p.Arg263Cys Uncertain significance Single submitter
- HMOX2 p.Arg47Gln Uncertain significance Single submitter
- HMOX2 p.Asn235His Uncertain significance Single submitter
- HMOX2 p.Asn235Ser Uncertain significance Single submitter
- HMOX2 p.Asp160Asn Uncertain significance Single submitter
- HMOX2 p.Asp273Gly Uncertain significance Single submitter
- HMOX2 p.Asp90Asn Uncertain significance Single submitter
- HMOX2 p.Cys282Ser Uncertain significance Single submitter
- HMOX2 p.Glu123Ala Uncertain significance Single submitter
- HMOX2 p.Glu13Lys Uncertain significance Single submitter
- HMOX2 p.Glu221Ala Uncertain significance Single submitter
- HMOX2 p.Gly10Glu Uncertain significance Single submitter
- HMOX2 p.Gly20Glu Uncertain significance Single submitter
- HMOX2 p.Gly40Arg Uncertain significance Single submitter
- HMOX2 p.Gly60Ala Uncertain significance Single submitter
- HMOX2 p.Ile233Leu Uncertain significance Single submitter
- HMOX2 p.Ile62Thr Uncertain significance Single submitter
- HMOX2 p.Leu81Arg Uncertain significance Single submitter
- HMOX2 p.Lys129Met Uncertain significance Single submitter
- HMOX2 p.Pro266Ser Uncertain significance Single submitter
- HMOX2 p.Ser162Leu Uncertain significance Single submitter
- HMOX2 p.Ser242Phe Uncertain significance Single submitter
- HMOX2 p.Tyr229Cys Uncertain significance Single submitter
- HMOX2 p.Tyr314His Uncertain significance Single submitter
- HMOX2 p.Tyr315Cys Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- HMOX2 p.Ala108Val Uncertain significance Single submitter
- HMOX2 p.Ala240Pro Uncertain significance Single submitter
- HMOX2 p.Arg47Trp Uncertain significance Single submitter
- HMOX2 p.Asn224Asp Uncertain significance Single submitter
- HMOX2 p.Glu65Gly Uncertain significance Single submitter
- HMOX2 p.Ile233Met Uncertain significance Single submitter
- HMOX2 p.Lys169Asn Uncertain significance Single submitter
- HMOX2 p.Val166Met Uncertain significance Single submitter
All HMOX2 variants
Benign 1
- p.Leu103= Multiple submitters
Likely benign 3
- p.Gln132Arg Single submitter
- p.Glu271Lys Single submitter
- p.Leu310Phe Single submitter
Uncertain significance 41
- p.Ala108Val Single submitter ⚠
- p.Ala131Ser Single submitter ⚠
- p.Ala208Thr Single submitter ⚠
- p.Ala240Pro Single submitter ⚠
- p.Ala287Pro Single submitter ⚠
- p.Ala302Val Single submitter ⚠
- p.Ala80Gly Single submitter
- p.Ala95Ser Single submitter ⚠
- p.Arg156Cys Single submitter ⚠
- p.Arg263Cys Single submitter ⚠
- p.Arg47Gln Single submitter ⚠
- p.Arg47Trp Single submitter ⚠
- p.Asn224Asp Single submitter ⚠
- p.Asn235His Single submitter ⚠
- p.Asn235Ser Single submitter ⚠
- p.Asp160Asn Single submitter ⚠
- p.Asp273Gly Single submitter ⚠
- p.Asp90Asn Single submitter ⚠
- p.Cys282Ser Single submitter ⚠
- p.Glu123Ala Single submitter ⚠
- p.Glu13Lys Single submitter ⚠
- p.Glu221Ala Single submitter ⚠
- p.Glu65Gly Single submitter ⚠
- p.Gly10Glu Single submitter ⚠
- p.Gly20Glu Single submitter ⚠
- p.Gly40Arg Single submitter ⚠
- p.Gly60Ala Single submitter ⚠
- p.Ile233Leu Single submitter ⚠
- p.Ile233Met Single submitter ⚠
- p.Ile62Thr Single submitter ⚠
- p.Leu81Arg Single submitter ⚠
- p.Lys129Met Single submitter ⚠
- p.Lys169Asn Single submitter ⚠
- p.Pro266Ser Single submitter ⚠
- p.Ser162Leu Single submitter ⚠
- p.Ser242Phe Single submitter ⚠
- p.Tyr229Cys Single submitter ⚠
- p.Tyr314His Single submitter ⚠
- p.Tyr315Cys Single submitter ⚠
- p.Val166Met Single submitter ⚠
- p.Val220Met Single submitter