HNRNPF — 23 ClinVar variants
All ClinVar germline HNRNPF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
1 Likely benign · 22 Uncertain significance
Full HNRNPF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HNRNPF p.Ala235Ser Uncertain significance Single submitter
- HNRNPF p.Ala371Val Uncertain significance Single submitter
- HNRNPF p.Asn369Ser Uncertain significance Single submitter
- HNRNPF p.Asp278Asn Uncertain significance Single submitter
- HNRNPF p.Gln129His Uncertain significance Single submitter
- HNRNPF p.Glu163Asp Uncertain significance Single submitter
- HNRNPF p.Gly241Ala Uncertain significance Single submitter
- HNRNPF p.Gly402Arg Uncertain significance Single submitter
- HNRNPF p.Gly4Cys Uncertain significance Single submitter
- HNRNPF p.Gly8Val Uncertain significance Single submitter
- HNRNPF p.Ile220Val Uncertain significance Single submitter
- HNRNPF p.Ile319Val Uncertain significance Single submitter
- HNRNPF p.Met271Ile Uncertain significance Single submitter
- HNRNPF p.Ser250Thr Uncertain significance Single submitter
- HNRNPF p.Tyr246Phe Uncertain significance Single submitter
- HNRNPF p.Tyr414Asp Uncertain significance Single submitter
- HNRNPF p.Val145Met Uncertain significance Single submitter
- HNRNPF p.Val67Ile Uncertain significance Single submitter
- HNRNPF p.Gly261Arg Uncertain significance No assertion criteria
Predictors split 3
The independent predictors disagree with each other — read with care.
All HNRNPF variants
Likely benign 1
- p.Leu15= Single submitter
Uncertain significance 22
- p.Ala235Ser Single submitter ⚠
- p.Ala371Val Single submitter ⚠
- p.Arg212Pro Single submitter ⚠
- p.Asn369Ser Single submitter ⚠
- p.Asp278Asn Single submitter ⚠
- p.Gln129His Single submitter ⚠
- p.Glu163Asp Single submitter ⚠
- p.Gly241Ala Single submitter ⚠
- p.Gly402Arg Single submitter ⚠
- p.Gly4Cys Single submitter ⚠
- p.Gly8Val Single submitter ⚠
- p.His44Arg Single submitter ⚠
- p.Ile220Val Single submitter ⚠
- p.Ile319Val Single submitter ⚠
- p.Met271Ile Single submitter ⚠
- p.Ser250Thr Single submitter ⚠
- p.Tyr240Cys Single submitter ⚠
- p.Tyr246Phe Single submitter ⚠
- p.Tyr414Asp Single submitter ⚠
- p.Val145Met Single submitter ⚠
- p.Val67Ile Single submitter ⚠
- p.Gly261Arg No assertion criteria ⚠