HNRNPM — 93 ClinVar variants
All ClinVar germline HNRNPM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →
4 Benign · 2 Likely benign · 87 Uncertain significance
Full HNRNPM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 87
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HNRNPM p.Ala3Thr Uncertain significance Single submitter
- HNRNPM p.Ala421Val Uncertain significance Single submitter
- HNRNPM p.Ala499Thr Uncertain significance Single submitter
- HNRNPM p.Ala535Thr Uncertain significance Single submitter
- HNRNPM p.Ala552Val Uncertain significance Single submitter
- HNRNPM p.Ala560Thr Uncertain significance Single submitter
- HNRNPM p.Ala595Thr Uncertain significance Single submitter
- HNRNPM p.Ala602Thr Uncertain significance Single submitter
- HNRNPM p.Ala617Ser Uncertain significance Single submitter
- HNRNPM p.Ala617Thr Uncertain significance Single submitter
- HNRNPM p.Ala641Gly Uncertain significance Single submitter
- HNRNPM p.Ala682Thr Uncertain significance Single submitter
- HNRNPM p.Ala7Pro Uncertain significance Single submitter
- HNRNPM p.Ala8Val Uncertain significance Single submitter
- HNRNPM p.Arg154Lys Uncertain significance Single submitter
- HNRNPM p.Arg449Leu Uncertain significance Single submitter
- HNRNPM p.Arg627Cys Uncertain significance Single submitter
- HNRNPM p.Arg728Ser Uncertain significance Single submitter
- HNRNPM p.Asn188Ser Uncertain significance Single submitter
- HNRNPM p.Asn31Ser Uncertain significance Single submitter
- HNRNPM p.Asn59Ser Uncertain significance Single submitter
- HNRNPM p.Asn66Ser Uncertain significance Single submitter
- HNRNPM p.Glu151Asp Uncertain significance Single submitter
- HNRNPM p.Glu20Ala Uncertain significance Single submitter
- HNRNPM p.Gly23Arg Uncertain significance Single submitter
- HNRNPM p.Gly32Glu Uncertain significance Single submitter
- HNRNPM p.Gly340Glu Uncertain significance Single submitter
- HNRNPM p.Gly354Ser Uncertain significance Single submitter
- HNRNPM p.Gly366Ala Uncertain significance Single submitter
- HNRNPM p.Gly415Ser Uncertain significance Single submitter
- HNRNPM p.Gly482Ser Uncertain significance Single submitter
- HNRNPM p.Gly489Ser Uncertain significance Single submitter
- HNRNPM p.Gly616Ser Uncertain significance Single submitter
- HNRNPM p.His464Arg Uncertain significance Single submitter
- HNRNPM p.His644Arg Uncertain significance Single submitter
- HNRNPM p.Ile385Leu Uncertain significance Single submitter
- HNRNPM p.Ile508Leu Uncertain significance Single submitter
- HNRNPM p.Ile522Val Uncertain significance Single submitter
- HNRNPM p.Lys126Arg Uncertain significance Single submitter
- HNRNPM p.Met167Thr Uncertain significance Single submitter
- HNRNPM p.Met263Val Uncertain significance Single submitter
- HNRNPM p.Met346Ile Uncertain significance Single submitter
- HNRNPM p.Pro171Gln Uncertain significance Single submitter
- HNRNPM p.Pro181Ser Uncertain significance Single submitter
- HNRNPM p.Pro28Leu Uncertain significance Single submitter
- HNRNPM p.Pro36Ala Uncertain significance Single submitter
- HNRNPM p.Pro36Ser Uncertain significance Single submitter
- HNRNPM p.Pro43Leu Uncertain significance Single submitter
- HNRNPM p.Pro702Leu Uncertain significance Single submitter
- HNRNPM p.Ser452Pro Uncertain significance Single submitter
- HNRNPM p.Thr14Lys Uncertain significance Single submitter
- HNRNPM p.Val11Met Uncertain significance Single submitter
- HNRNPM p.Val430Met Uncertain significance Single submitter
- HNRNPM p.Val447Ala Uncertain significance Single submitter
- HNRNPM p.Val515Met Uncertain significance Single submitter
- HNRNPM p.Val547Met Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- HNRNPM p.Arg293Leu Uncertain significance Single submitter
- HNRNPM p.Arg418Cys Uncertain significance Single submitter
- HNRNPM p.Arg418His Uncertain significance Single submitter
- HNRNPM p.Arg456Leu Uncertain significance Single submitter
- HNRNPM p.Arg517Cys Uncertain significance Single submitter
- HNRNPM p.Arg591His Uncertain significance Single submitter
- HNRNPM p.Arg606Cys Uncertain significance Single submitter
- HNRNPM p.Arg627His Uncertain significance Single submitter
- HNRNPM p.Asp620Ala Uncertain significance Single submitter
- HNRNPM p.Glu433Lys Uncertain significance Single submitter
- HNRNPM p.Glu523Lys Uncertain significance Single submitter
- HNRNPM p.Glu577Lys Uncertain significance Single submitter
- HNRNPM p.Glu590Lys Uncertain significance Single submitter
- HNRNPM p.Glu605Gly Uncertain significance Single submitter
- HNRNPM p.Glu624Lys Uncertain significance Single submitter
- HNRNPM p.Gly23Cys Uncertain significance Single submitter
- HNRNPM p.Gly597Cys Uncertain significance Single submitter
- HNRNPM p.Ile255Thr Uncertain significance Single submitter
- HNRNPM p.Leu423Pro Uncertain significance Single submitter
- HNRNPM p.Leu563Arg Uncertain significance Single submitter
- HNRNPM p.Lys69Glu Uncertain significance Single submitter
- HNRNPM p.Met278Val Uncertain significance Single submitter
- HNRNPM p.Met326Ile Uncertain significance Single submitter
- HNRNPM p.Met465Ile Uncertain significance Single submitter
- HNRNPM p.Met465Thr Uncertain significance Single submitter
- HNRNPM p.Met486Val Uncertain significance Single submitter
- HNRNPM p.Met497Val Uncertain significance Single submitter
- HNRNPM p.Met525Val Uncertain significance Single submitter
- HNRNPM p.Met558Val Uncertain significance Single submitter
- HNRNPM p.Val231Gly Uncertain significance Single submitter
- HNRNPM p.Arg710Gln Uncertain significance No assertion criteria
All HNRNPM variants
Benign 4
- p.Gly351= Multiple submitters
- p.Gly601= Multiple submitters
- c.835-7C>G Single submitter
- p.Thr553= Single submitter
Likely benign 2
- p.Ala705= Single submitter
- p.Gly26Ser No assertion criteria long QT syndrome
Uncertain significance 87
- p.Ala3Thr Single submitter ⚠
- p.Ala421Val Single submitter ⚠
- p.Ala499Thr Single submitter ⚠
- p.Ala535Thr Single submitter ⚠
- p.Ala552Val Single submitter ⚠
- p.Ala560Thr Single submitter ⚠
- p.Ala595Thr Single submitter ⚠
- p.Ala602Thr Single submitter ⚠
- p.Ala617Ser Single submitter ⚠
- p.Ala617Thr Single submitter ⚠
- p.Ala641Gly Single submitter ⚠
- p.Ala682Thr Single submitter ⚠
- p.Ala7Pro Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg154Lys Single submitter ⚠
- p.Arg293Leu Single submitter ⚠
- p.Arg418Cys Single submitter ⚠
- p.Arg418His Single submitter ⚠
- p.Arg449Leu Single submitter ⚠
- p.Arg456Leu Single submitter ⚠
- p.Arg517Cys Single submitter ⚠
- p.Arg591His Single submitter ⚠
- p.Arg606Cys Single submitter ⚠
- p.Arg627Cys Single submitter ⚠
- p.Arg627His Single submitter ⚠
- p.Arg728Ser Single submitter ⚠
- p.Asn188Ser Single submitter ⚠
- p.Asn31Ser Single submitter ⚠
- p.Asn59Ser Single submitter ⚠
- p.Asn66Ser Single submitter ⚠
- p.Asp620Ala Single submitter ⚠
- p.Glu151Asp Single submitter ⚠
- p.Glu20Ala Single submitter ⚠
- p.Glu433Lys Single submitter ⚠
- p.Glu523Lys Single submitter ⚠
- p.Glu577Lys Single submitter ⚠
- p.Glu590Lys Single submitter ⚠
- p.Glu605Gly Single submitter ⚠
- p.Glu624Lys Single submitter ⚠
- p.Gly23Arg Single submitter ⚠
- p.Gly23Cys Single submitter ⚠
- p.Gly32Glu Single submitter ⚠
- p.Gly340Glu Single submitter ⚠
- p.Gly354Ser Single submitter ⚠
- p.Gly366Ala Single submitter ⚠
- p.Gly415Ser Single submitter ⚠
- p.Gly482Ser Single submitter ⚠
- p.Gly489Ser Single submitter ⚠
- p.Gly597Cys Single submitter ⚠
- p.Gly616Ser Single submitter ⚠
- p.His464Arg Single submitter ⚠
- p.His644Arg Single submitter ⚠
- p.Ile255Thr Single submitter ⚠
- p.Ile385Leu Single submitter ⚠
- p.Ile508Leu Single submitter ⚠
- p.Ile522Val Single submitter ⚠
- p.Leu423Pro Single submitter ⚠
- p.Leu563Arg Single submitter ⚠
- p.Lys126Arg Single submitter ⚠
- p.Lys69Glu Single submitter ⚠
- p.Met167Thr Single submitter ⚠
- p.Met263Val Single submitter ⚠
- p.Met278Val Single submitter ⚠
- p.Met326Ile Single submitter ⚠
- p.Met346Ile Single submitter ⚠
- p.Met465Ile Single submitter ⚠
- p.Met465Thr Single submitter ⚠
- p.Met486Val Single submitter ⚠
- p.Met497Val Single submitter ⚠
- p.Met525Val Single submitter ⚠
- p.Met558Val Single submitter ⚠
- p.Pro171Gln Single submitter ⚠
- p.Pro181Ser Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro36Ala Single submitter ⚠
- p.Pro36Ser Single submitter ⚠
- p.Pro43Leu Single submitter ⚠
- p.Pro702Leu Single submitter ⚠
- p.Ser452Pro Single submitter ⚠
- p.Thr14Lys Single submitter ⚠
- p.Val11Met Single submitter ⚠
- p.Val231Gly Single submitter ⚠
- p.Val430Met Single submitter ⚠
- p.Val447Ala Single submitter ⚠
- p.Val515Met Single submitter ⚠
- p.Val547Met Single submitter ⚠
- p.Arg710Gln No assertion criteria ⚠