HOXB13 — 1662 ClinVar variants

All ClinVar germline HOXB13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 855 flagged for review →

1 Pathogenic · 48 Conflicting · 27 Benign · 115 Benign/Likely benign · 127 Likely benign · 1344 Uncertain significance

Full HOXB13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 855

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 35

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

HOXB13 p.Ala101Val Conflicting Single submitter
prostate cancer, hereditary, 9
HOXB13 p.Ala111Thr Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ala12Thr Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ala175Ser Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ala197Thr Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ala212Thr Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ala21Gly Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ala21Thr Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ala21Val Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ala282Thr Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ala29Ser Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ala29Thr Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Arg123His Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Asn47Ser Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Gly22Arg Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Gly23Ala Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Gly23Arg Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Gly23Glu Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Gly55Ala Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Gly55Ser Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Met43Thr Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Pro110Ser Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Pro114Ser Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Pro40Ser Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Pro70Thr Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ser171Pro Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ser56Leu Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ser93Ala Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Thr105Ser Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Thr115Lys Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Thr41Met Conflicting Single submitter
prostate cancer, hereditary, 9
HOXB13 p.Thr73Lys Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Thr73Met Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Val278Leu Conflicting Single submitter
hereditary neoplastic syndrome
HOXB13 p.Val78Met Conflicting Single submitter
hereditary neoplastic syndrome

Predictors lean, ClinVar uncertain 631

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 631

HOXB13 p.Ala103Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala103Val Uncertain significance Multiple submitters
prostate cancer, hereditary, 9
HOXB13 p.Ala104Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala104Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala104Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala107Pro Uncertain significance Multiple submitters
prostate cancer, hereditary, 9
HOXB13 p.Ala107Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala107Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala108Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala108Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala111Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala111Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala128Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala128Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala141Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala141Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala154Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala154Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala197Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala198Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala200Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala200Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala210Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala210Val Uncertain significance Multiple submitters
prostate cancer, hereditary, 9
HOXB13 p.Ala212Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala212Pro Uncertain significance Multiple submitters
prostate cancer, hereditary, 9
HOXB13 p.Ala212Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala212Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala21Glu Uncertain significance Multiple submitters
HOXB13 p.Ala236Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala236Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala237Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala251Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala251Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala276Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala276Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala276Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala282Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala282Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala29Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala38Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala38Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala38Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala39Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala39Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala39Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala49Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala57Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala57Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala57Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala76Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala7Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala7Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg214Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg215Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg215Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg215His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg215Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg217Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg217Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg217His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg217Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg217Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg220Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg220His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg220Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg229Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg229Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg229Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg233Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg233Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg233Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg246Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg247Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg258Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg258His Uncertain significance Multiple submitters
prostate cancer, hereditary, 9
HOXB13 p.Arg258Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg258Ser Uncertain significance Multiple submitters
HOXB13 p.Arg25Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg25Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg267Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg267Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg267His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg267Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg268Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg268Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg268Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg268Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg91Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg94Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg94Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg94Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asn238Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asn266Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asn266Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asn26His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asn26Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asn47Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asp10Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asp167Asn Uncertain significance Multiple submitters
HOXB13-related disorder
HOXB13 p.Asp167Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asp244Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asp244Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asp244Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Cys100Phe Uncertain significance Multiple submitters
prostate cancer, hereditary, 9
HOXB13 p.Cys100Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Cys66Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gln150Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gln205Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gln205Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gln227Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gln227Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gln259Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu118Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu119Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu119Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu157Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu187Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu230Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu232Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu232Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu234Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu257Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu257Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu271Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu2Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu2Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly117Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly117Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly117Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly176Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly186Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly192Cys Uncertain significance Multiple submitters
prostate cancer, hereditary, 9
HOXB13 p.Gly192Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly204Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly204Trp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly216Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly226Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly22Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly22Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly23Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly24Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly4Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly4Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly4Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly68Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly68Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly72Val Uncertain significance Multiple submitters
HOXB13-related disorder
HOXB13 p.Gly81Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly85Asp Uncertain significance Multiple submitters
prostate cancer, hereditary, 9

Predictors split 189

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 189

HOXB13 p.Ala128Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala128Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala173Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala173Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala236Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg159Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg159Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg159Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg214Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg214His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg233Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg247His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Arg247Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asn238Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asp10Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asp145Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asp145Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asp161Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Asp161Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Cys184Phe Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Cys184Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Cys63Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Cys66Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Cys90Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gln138Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gln170Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gln181His Uncertain significance Multiple submitters
prostate cancer, hereditary, 9
HOXB13 p.Gln181Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gln188Arg Uncertain significance Multiple submitters
prostate cancer, hereditary, 9
HOXB13 p.Gln188Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu16Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu232Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Glu234Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly132Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly135Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly153Cys Uncertain significance Multiple submitters
prostate cancer, hereditary, 9
HOXB13 p.Gly153Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly156Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly177Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly17Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly17Asp Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly17Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly17Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly216Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Gly216Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ile249Met Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ile262Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ile262Val Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Leu144Met Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Leu164Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Lys218Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Lys239Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Lys239Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Lys270Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Lys273Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Lys279Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Lys61Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Lys98Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Met182Lys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Met182Thr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Phe127Tyr Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Phe240Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Pro124Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Pro158Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Pro158Gln Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Pro158Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Pro165Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Pro165Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ser122Arg Uncertain significance Multiple submitters
prostate cancer, hereditary, 9
HOXB13 p.Ser168Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ser168Ile Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ser180Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ser254Arg Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ser281Gly Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Thr151Pro Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Thr242Asn Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Thr242Ile Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Trp172Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Tyr133His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Tyr137Cys Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Tyr143His Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Tyr82Ser Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Val146Ala Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Val149Met Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Val269Ile Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Val269Leu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Val92Glu Uncertain significance Multiple submitters
hereditary neoplastic syndrome
HOXB13 p.Ala141Val Uncertain significance Single submitter
HOXB13 p.Ala173Asp Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ala252Asp Uncertain significance Single submitter
HOXB13 p.Ala276Asp Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Asn238His Uncertain significance Single submitter
HOXB13 p.Asn238Lys Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Asn238Thr Uncertain significance Single submitter
HOXB13 p.Asp10Val Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Asp145Ala Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Asp145Gly Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Asp167Gly Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Asp167Tyr Uncertain significance Single submitter
HOXB13 p.Asp201Tyr Uncertain significance Single submitter
prostate cancer, hereditary, 1
HOXB13 p.Cys184Ser Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Cys66Trp Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Gln138His Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Gln181Arg Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Glu126Gly Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Glu271Asp Uncertain significance Single submitter
prostate cancer, hereditary, 1
HOXB13 p.Gly153Arg Uncertain significance Single submitter
HOXB13 p.Gly153Asp Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Gly177Asp Uncertain significance Single submitter
HOXB13 p.Gly226Arg Uncertain significance Single submitter
HOXB13 p.Gly84Arg Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Gly86Arg Uncertain significance Single submitter
HOXB13 p.His160Arg Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.His160Leu Uncertain significance Single submitter
HOXB13 p.His160Tyr Uncertain significance Single submitter
HOXB13 p.Ile221Met Uncertain significance Single submitter
HOXB13 p.Ile249Val Uncertain significance Single submitter
HOXB13 p.Leu144Val Uncertain significance Single submitter
HOXB13 p.Leu163Gln Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Leu163Pro Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Lys239Glu Uncertain significance Single submitter
HOXB13 p.Lys245Arg Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Lys277Arg Uncertain significance Single submitter
HOXB13 p.Lys277Asn Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Lys277Glu Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Lys279Arg Uncertain significance Single submitter
HOXB13 p.Phe127Cys Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Phe127Ser Uncertain significance Single submitter
HOXB13 p.Phe199Leu Uncertain significance Single submitter
prostate cancer, hereditary, 1
HOXB13 p.Phe213Leu Uncertain significance Single submitter
HOXB13 p.Phe213Ser Uncertain significance Single submitter
HOXB13 p.Pro165Ala Uncertain significance Single submitter
prostate cancer, hereditary, 1
HOXB13 p.Ser142Arg Uncertain significance Single submitter
HOXB13 p.Ser142Cys Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Ser224Asn Uncertain significance Single submitter
HOXB13 p.Ser281Arg Uncertain significance Single submitter
HOXB13 p.Ser89Phe Uncertain significance Single submitter
HOXB13 p.Thr151Ile Uncertain significance Single submitter
prostate cancer, hereditary, 1
HOXB13 p.Thr242Ala Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Thr253Ile Uncertain significance Single submitter
HOXB13 p.Thr261Ala Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Thr261Ser Uncertain significance Single submitter
HOXB13 p.Trp172Arg Uncertain significance Single submitter
HOXB13 p.Trp178Cys Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Trp195Arg Uncertain significance Single submitter
HOXB13 p.Tyr133Cys Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Tyr137Phe Uncertain significance Single submitter
hereditary neoplastic syndrome
HOXB13 p.Tyr169Asp Uncertain significance Single submitter
HOXB13 p.Tyr169Cys Uncertain significance Single submitter
HOXB13 p.Tyr169His Uncertain significance Single submitter

All HOXB13 variants

Pathogenic 1

p.Lys272Ter No assertion criteria gastric cancer

Conflicting classifications of pathogenicity 48

c.601+7C>G Single submitter prostate cancer
c.602-5C>A Single submitter hereditary neoplastic syndrome
c.602-5C>G Single submitter hereditary neoplastic syndrome
c.602-5C>T Single submitter prostate cancer, hereditary, 9
c.602-7C>A Single submitter
c.*8_*10del Single submitter prostate cancer, hereditary, 9
p.Ala101= Single submitter hereditary neoplastic syndrome
p.Ala101Val Single submitter prostate cancer, hereditary, 9 ⚠
p.Ala111Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala12Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala175Ser Single submitter hereditary neoplastic syndrome ⚠
p.Ala197Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala212Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala21Gly Single submitter hereditary neoplastic syndrome ⚠
p.Ala21Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala21Val Single submitter hereditary neoplastic syndrome ⚠
p.Ala276= Single submitter prostate cancer, hereditary, 9
p.Ala282Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ala29Ser Single submitter hereditary neoplastic syndrome ⚠
p.Ala29Thr Single submitter hereditary neoplastic syndrome ⚠
p.Arg123His Single submitter hereditary neoplastic syndrome ⚠
p.Arg268= Single submitter prostate cancer, hereditary, 9
p.Asn47Ser Single submitter hereditary neoplastic syndrome ⚠
p.Glu2= Single submitter prostate cancer, hereditary, 9
p.Gly22Arg Single submitter hereditary neoplastic syndrome ⚠
p.Gly23Ala Single submitter hereditary neoplastic syndrome ⚠
p.Gly23Arg Single submitter hereditary neoplastic syndrome ⚠
p.Gly23Glu Single submitter hereditary neoplastic syndrome ⚠
p.Gly55Ala Single submitter hereditary neoplastic syndrome ⚠
p.Gly55Ser Single submitter hereditary neoplastic syndrome ⚠
p.Gly72= Single submitter hereditary neoplastic syndrome
p.Gly85= Single submitter hereditary neoplastic syndrome
p.Met43Thr Single submitter hereditary neoplastic syndrome ⚠
p.Pro110Ser Single submitter hereditary neoplastic syndrome ⚠
p.Pro114Ser Single submitter hereditary neoplastic syndrome ⚠
p.Pro40Ser Single submitter hereditary neoplastic syndrome ⚠
p.Pro70Thr Single submitter hereditary neoplastic syndrome ⚠
p.Ser171Pro Single submitter hereditary neoplastic syndrome ⚠
p.Ser56Leu Single submitter hereditary neoplastic syndrome ⚠
p.Ser93Ala Single submitter hereditary neoplastic syndrome ⚠
p.Thr105Ser Single submitter hereditary neoplastic syndrome ⚠
p.Thr115Lys Single submitter hereditary neoplastic syndrome ⚠
p.Thr41Met Single submitter prostate cancer, hereditary, 9 ⚠
p.Thr73Lys Single submitter hereditary neoplastic syndrome ⚠
p.Thr73Met Single submitter hereditary neoplastic syndrome ⚠
p.Val166= Single submitter prostate cancer, hereditary, 9
p.Val278Leu Single submitter hereditary neoplastic syndrome ⚠
p.Val78Met Single submitter hereditary neoplastic syndrome ⚠

Benign 27

c.601+134G>A Multiple submitters
c.601+49G>A Single submitter
c.602-335G>A Single submitter
c.-47C>T Single submitter
c.*28C>A Single submitter
c.*3G>A Single submitter prostate cancer, hereditary, 9
c.*5T>A Single submitter prostate cancer, hereditary, 9
c.*5T>G Single submitter prostate cancer, hereditary, 9
c.*7T>C Single submitter prostate cancer, hereditary, 9
c.*8C>A Single submitter prostate cancer, hereditary, 9
p.Ala7= Single submitter prostate cancer, hereditary, 9
p.Arg233= Single submitter prostate cancer, hereditary, 9
p.Arg247= Single submitter prostate cancer, hereditary, 9
p.Asp167= Single submitter prostate cancer, hereditary, 9
p.Cys100= Single submitter prostate cancer, hereditary, 9
p.Gln138= Single submitter prostate cancer, hereditary, 9
p.Gln205= Single submitter prostate cancer, hereditary, 9
p.Glu126= Single submitter prostate cancer, hereditary, 9
p.Gly132= Single submitter prostate cancer, hereditary, 9
p.Gly135= Single submitter prostate cancer, hereditary, 9
p.His36= Single submitter prostate cancer, hereditary, 9
p.Phe199= Single submitter prostate cancer, hereditary, 9
p.Pro121_Ser122= Single submitter prostate cancer, hereditary, 9
p.Pro190= Single submitter prostate cancer, hereditary, 9
p.Ser122_Arg123= Single submitter prostate cancer, hereditary, 9
p.Ser93= Single submitter prostate cancer, hereditary, 9
p.Thr8= Single submitter prostate cancer, hereditary, 9

Benign/Likely benign 115

c.602-9G>A Multiple submitters prostate cancer, hereditary, 9
p.Ala104= Multiple submitters prostate cancer, hereditary, 9
p.Ala107= Multiple submitters prostate cancer, hereditary, 9
p.Ala108= Multiple submitters prostate cancer, hereditary, 9
p.Ala111= Multiple submitters prostate cancer, hereditary, 9
p.Ala116= Multiple submitters prostate cancer, hereditary, 9
p.Ala173= Multiple submitters prostate cancer, hereditary, 9
p.Ala21= Multiple submitters prostate cancer, hereditary, 9
p.Ala236= Multiple submitters prostate cancer, hereditary, 9
p.Ala237= Multiple submitters prostate cancer, hereditary, 9
p.Ala29= Multiple submitters prostate cancer, hereditary, 9
p.Ala38= Multiple submitters hereditary neoplastic syndrome
p.Ala49= Multiple submitters prostate cancer, hereditary, 9
p.Arg214= Multiple submitters hereditary neoplastic syndrome
p.Arg215= Multiple submitters hereditary neoplastic syndrome
p.Arg229= Multiple submitters prostate cancer, hereditary, 9
p.Arg246= Multiple submitters prostate cancer, hereditary, 9
p.Arg25= Multiple submitters prostate cancer, hereditary, 9
p.Arg258= Multiple submitters prostate cancer, hereditary, 9
p.Arg267= Multiple submitters prostate cancer, hereditary, 9
p.Arg91= Multiple submitters prostate cancer, hereditary, 9
p.Asn189= Multiple submitters hereditary neoplastic syndrome
p.Asn266= Multiple submitters prostate cancer, hereditary, 9
p.Asn47= Multiple submitters prostate cancer, hereditary, 9
p.Asn5= Multiple submitters prostate cancer, hereditary, 9
p.Asp209= Multiple submitters prostate cancer, hereditary, 9
p.Cys211= Multiple submitters hereditary neoplastic syndrome
p.Cys63= Multiple submitters hereditary neoplastic syndrome
p.Gln102= Multiple submitters prostate cancer, hereditary, 9
p.Gln185= Multiple submitters prostate cancer, hereditary, 9
p.Gln259= Multiple submitters prostate cancer, hereditary, 9
p.Gln71= Multiple submitters prostate cancer, hereditary, 9
p.Glu112= Multiple submitters prostate cancer, hereditary, 9
p.Glu118= Multiple submitters prostate cancer, hereditary, 9
p.Glu187= Multiple submitters prostate cancer, hereditary, 9
p.Glu234= Multiple submitters hereditary neoplastic syndrome
p.Glu58= Multiple submitters prostate cancer, hereditary, 9
p.Gly117= Multiple submitters prostate cancer, hereditary, 9
p.Gly153= Multiple submitters prostate cancer, hereditary, 9
p.Gly20= Multiple submitters prostate cancer, hereditary, 9
p.Gly204= Multiple submitters prostate cancer, hereditary, 9
p.Gly226= Multiple submitters prostate cancer, hereditary, 9
p.Gly23= Multiple submitters hereditary neoplastic syndrome
p.Gly24= Multiple submitters prostate cancer, hereditary, 9
p.Gly68= Multiple submitters hereditary neoplastic syndrome
p.Gly84= Multiple submitters prostate cancer, hereditary, 9
p.His30= Multiple submitters prostate cancer, hereditary, 9
p.Ile241= Multiple submitters prostate cancer, hereditary, 9
p.Ile249= Multiple submitters hereditary neoplastic syndrome
p.Ile262= Multiple submitters prostate cancer, hereditary, 9
p.Leu106= Multiple submitters prostate cancer, hereditary, 9
p.Leu152= Multiple submitters hereditary neoplastic syndrome
p.Leu18= Multiple submitters prostate cancer, hereditary, 9
p.Leu19= Multiple submitters hereditary neoplastic syndrome
p.Leu228= Multiple submitters hereditary neoplastic syndrome
p.Leu255= Multiple submitters prostate cancer, hereditary, 9
p.Leu27= Multiple submitters hereditary neoplastic syndrome
p.Leu275= Multiple submitters prostate cancer, hereditary, 9
p.Leu33= Multiple submitters prostate cancer, hereditary, 9
p.Leu9= Multiple submitters prostate cancer, hereditary, 9
p.Lys13= Multiple submitters hereditary neoplastic syndrome
p.Lys225= Multiple submitters prostate cancer, hereditary, 9
p.Lys239= Multiple submitters prostate cancer, hereditary, 9
p.Lys245= Multiple submitters prostate cancer, hereditary, 9
p.Lys273= Multiple submitters prostate cancer, hereditary, 9
p.Lys61= Multiple submitters prostate cancer, hereditary, 9
p.Lys98= Multiple submitters prostate cancer, hereditary, 9
p.Phe129= Multiple submitters hereditary neoplastic syndrome
p.Phe240= Multiple submitters prostate cancer, hereditary, 9
p.Phe83= Multiple submitters hereditary neoplastic syndrome
p.Pro110= Multiple submitters hereditary neoplastic syndrome
p.Pro114= Multiple submitters hereditary neoplastic syndrome
p.Pro121= Multiple submitters prostate cancer, hereditary, 9
p.Pro131= Multiple submitters prostate cancer, hereditary, 9
p.Pro139= Multiple submitters prostate cancer, hereditary, 9
p.Pro155= Multiple submitters hereditary neoplastic syndrome
p.Pro158= Multiple submitters hereditary neoplastic syndrome
p.Pro165= Multiple submitters prostate cancer, hereditary, 9
p.Pro191= Multiple submitters prostate cancer, hereditary, 9
p.Pro222= Multiple submitters hereditary neoplastic syndrome
p.Pro3= Multiple submitters prostate cancer, hereditary, 9
p.Pro32= Multiple submitters hereditary neoplastic syndrome
p.Pro50= Multiple submitters prostate cancer, hereditary, 9
p.Pro59= Multiple submitters prostate cancer, hereditary, 9
p.Pro70= Multiple submitters prostate cancer, hereditary, 9
p.Pro77= Multiple submitters prostate cancer, hereditary, 9
p.Pro79= Multiple submitters prostate cancer, hereditary, 9
p.Ser122= Multiple submitters prostate cancer, hereditary, 9
p.Ser162= Multiple submitters prostate cancer, hereditary, 9
p.Ser171= Multiple submitters prostate cancer, hereditary, 9
p.Ser203= Multiple submitters prostate cancer, hereditary, 9
p.Ser250= Multiple submitters hereditary neoplastic syndrome
p.Ser254= Multiple submitters prostate cancer, hereditary, 9
p.Ser281= Multiple submitters prostate cancer, hereditary, 9
p.Ser35= Multiple submitters hereditary neoplastic syndrome
p.Ser56= Multiple submitters prostate cancer, hereditary, 9
p.Ser95= Multiple submitters hereditary neoplastic syndrome
p.Ser96= Multiple submitters hereditary neoplastic syndrome
p.Thr105= Multiple submitters prostate cancer, hereditary, 9
p.Thr115= Multiple submitters prostate cancer, hereditary, 9
p.Thr136= Multiple submitters prostate cancer, hereditary, 9
p.Thr253= Multiple submitters prostate cancer, hereditary, 9
p.Thr34= Multiple submitters hereditary neoplastic syndrome
p.Thr41= Multiple submitters prostate cancer, hereditary, 9
p.Tyr120= Multiple submitters prostate cancer, hereditary, 9
p.Tyr137= Multiple submitters prostate cancer, hereditary, 9
p.Tyr143= Multiple submitters hereditary neoplastic syndrome
p.Tyr169= Multiple submitters hereditary neoplastic syndrome
p.Tyr235= Multiple submitters prostate cancer, hereditary, 9
p.Tyr6= Multiple submitters prostate cancer, hereditary, 9
p.Tyr80= Multiple submitters prostate cancer, hereditary, 9
p.Tyr82= Multiple submitters prostate cancer, hereditary, 9
p.Val149= Multiple submitters hereditary neoplastic syndrome
p.Val28= Multiple submitters prostate cancer, hereditary, 9
p.Val78= Multiple submitters hereditary neoplastic syndrome

Likely benign 127

c.601+10T>C Multiple submitters prostate cancer, hereditary, 9
c.601+7C>A Multiple submitters prostate cancer, hereditary, 9
c.601+9A>G Multiple submitters prostate cancer, hereditary, 9
c.602-10C>T Multiple submitters prostate cancer, hereditary, 9
c.602-11A>G Multiple submitters prostate cancer, hereditary, 9
c.602-12C>T Multiple submitters prostate cancer, hereditary, 9
c.602-20C>T Multiple submitters prostate cancer, hereditary, 9
c.602-4G>C Multiple submitters prostate cancer, hereditary, 9
c.602-4G>T Multiple submitters prostate cancer, hereditary, 9
c.602-6G>A Multiple submitters prostate cancer, hereditary, 9
c.602-6G>T Multiple submitters prostate cancer, hereditary, 9
c.602-7C>T Multiple submitters prostate cancer, hereditary, 9
c.-6G>A Multiple submitters prostate cancer
p.Ala154= Multiple submitters hereditary neoplastic syndrome
p.Ala198= Multiple submitters hereditary neoplastic syndrome
p.Ala39= Multiple submitters hereditary neoplastic syndrome
p.Ala57= Multiple submitters hereditary neoplastic syndrome
p.Arg123= Multiple submitters hereditary neoplastic syndrome
p.Arg217= Multiple submitters hereditary neoplastic syndrome
p.Arg220= Multiple submitters hereditary neoplastic syndrome
p.Arg94= Multiple submitters
p.Asp201= Multiple submitters hereditary neoplastic syndrome
p.Cys183= Multiple submitters hereditary neoplastic syndrome
p.Cys184= Multiple submitters hereditary neoplastic syndrome
p.Glu119= Multiple submitters hereditary neoplastic syndrome
p.Glu232= Multiple submitters hereditary neoplastic syndrome
p.Gly216= Multiple submitters hereditary neoplastic syndrome
p.His206= Multiple submitters hereditary neoplastic syndrome
p.His64= Multiple submitters hereditary neoplastic syndrome
p.Leu144= Multiple submitters hereditary neoplastic syndrome
p.Leu163= Multiple submitters hereditary neoplastic syndrome
p.Leu164= Multiple submitters hereditary neoplastic syndrome
p.Lys218= Multiple submitters hereditary neoplastic syndrome
p.Lys270= Multiple submitters hereditary neoplastic syndrome
p.Lys277= Multiple submitters hereditary neoplastic syndrome
p.Pro134= Multiple submitters hereditary neoplastic syndrome
p.Pro193= Multiple submitters hereditary neoplastic syndrome
p.Pro65= Multiple submitters hereditary neoplastic syndrome
p.Ser202= Multiple submitters hereditary neoplastic syndrome
p.Thr151= Multiple submitters hereditary neoplastic syndrome
p.Thr73= Multiple submitters hereditary neoplastic syndrome
p.Tyr109= Multiple submitters hereditary neoplastic syndrome
p.Tyr87= Multiple submitters hereditary neoplastic syndrome
p.Val269= Multiple submitters hereditary neoplastic syndrome
p.Val46= Multiple submitters hereditary neoplastic syndrome
p.Val69= Multiple submitters hereditary neoplastic syndrome
c.601+11T>C Single submitter
c.601+12del Single submitter
c.601+12dup Single submitter
c.601+14C>G Single submitter
c.601+14C>T Single submitter
c.601+15C>G Single submitter
c.601+15del Single submitter
c.601+16T>A Single submitter
c.601+16T>C Single submitter
c.601+17_601+25del Single submitter
c.601+17G>A Single submitter
c.601+19G>A Single submitter prostate cancer, hereditary, 1
c.601+9A>C Single submitter
c.602-13dup Single submitter
c.602-16C>A Single submitter
c.602-16C>T Single submitter prostate cancer, hereditary, 1
c.602-17C>T Single submitter prostate cancer, hereditary, 9
c.602-18C>T Single submitter
c.602-19T>G Single submitter
c.602-20del Single submitter
c.602-8C>T Single submitter prostate cancer, hereditary, 9
c.*57G>A Single submitter
p.Ala175= Single submitter hereditary neoplastic syndrome
p.Ala197= Single submitter prostate cancer, hereditary, 1
p.Ala212= Single submitter
p.Ala236Ser Single submitter hereditary neoplastic syndrome
p.Ala282= Single submitter
p.Ala45= Single submitter
p.Ala49Ser Single submitter hereditary neoplastic syndrome
p.Arg159= Single submitter
p.Asn280= Single submitter
p.Asp14= Single submitter hereditary neoplastic syndrome
p.Asp145= Single submitter hereditary neoplastic syndrome
p.Asp161= Single submitter hereditary neoplastic syndrome
p.Asp244= Single submitter
p.Cys66= Single submitter hereditary neoplastic syndrome
p.Cys90= Single submitter
p.Gln170= Single submitter hereditary neoplastic syndrome
p.Gln265= Single submitter
p.Glu230= Single submitter hereditary neoplastic syndrome
p.Gly11= Single submitter
p.Gly23Trp Single submitter hereditary neoplastic syndrome
p.Gly4= Single submitter
p.Gly55= Single submitter
p.Gly81= Single submitter hereditary neoplastic syndrome
p.Gly86= Single submitter
p.Ile15= Single submitter hereditary neoplastic syndrome
p.Ile260= Single submitter
p.Leu174= Single submitter
p.Leu231= Single submitter hereditary neoplastic syndrome
p.Leu42= Single submitter
p.Lys219= Single submitter
p.Lys248= Single submitter hereditary neoplastic syndrome
p.Lys272= Single submitter hereditary neoplastic syndrome
p.Met43Lys Single submitter hereditary neoplastic syndrome
p.Phe127= Single submitter hereditary neoplastic syndrome
p.Phe213= Single submitter hereditary neoplastic syndrome
p.Pro124= Single submitter hereditary neoplastic syndrome
p.Pro208= Single submitter hereditary neoplastic syndrome
p.Pro37= Single submitter hereditary neoplastic syndrome
p.Pro44= Single submitter hereditary neoplastic syndrome
p.Pro67= Single submitter hereditary neoplastic syndrome
p.Pro99= Single submitter hereditary neoplastic syndrome
p.Pro99Thr Single submitter hereditary neoplastic syndrome
p.Ser122Asn Single submitter hereditary neoplastic syndrome
p.Ser142= Single submitter hereditary neoplastic syndrome
p.Ser147= Single submitter hereditary neoplastic syndrome
p.Ser180= Single submitter
p.Ser224= Single submitter hereditary neoplastic syndrome
p.Ser256= Single submitter
p.Ser31= Single submitter hereditary neoplastic syndrome
p.Ser74= Single submitter
p.Ser89= Single submitter hereditary neoplastic syndrome
p.Ter285= Single submitter
p.Thr113= Single submitter hereditary neoplastic syndrome
p.Thr242= Single submitter
p.Thr261= Single submitter
p.Thr283= Single submitter hereditary neoplastic syndrome
p.Tyr133= Single submitter hereditary neoplastic syndrome
p.Tyr223= Single submitter hereditary neoplastic syndrome
p.Tyr48= Single submitter hereditary neoplastic syndrome

Uncertain significance 1344

Showing the top 300 by review status; the full set is in the sitemap.

c.601+1G>T Multiple submitters hereditary neoplastic syndrome
c.601+2T>C Multiple submitters hereditary neoplastic syndrome
c.601+4C>T Multiple submitters hereditary neoplastic syndrome
c.602-10C>G Multiple submitters
c.602-3C>A Multiple submitters hereditary neoplastic syndrome
c.602-3C>G Multiple submitters hereditary neoplastic syndrome
c.602-5_602-4insA Multiple submitters hereditary neoplastic syndrome
p.Ala103Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala103Val Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Ala104Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala104del Multiple submitters hereditary neoplastic syndrome
p.Ala104Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala104Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala107Pro Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Ala107Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala107Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala108fs Multiple submitters hereditary neoplastic syndrome
p.Ala108Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala108Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala111Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala111Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala128Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala128Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala128Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala128Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala141Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala141Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala154Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala154Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala173Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala173Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala197Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala198Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala200Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala200Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala210Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala210Val Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Ala212Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala212Pro Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Ala212Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala212Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala21Glu Multiple submitters ⚠
p.Ala236Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala236Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala236Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala237Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala251Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala251Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala276Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala276Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala276Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala282Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala282Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala29Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala38Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala38Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala38Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala39Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala39Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala39Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala49Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala57Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala57Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala57Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala76Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala7Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Ala7Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg123fs Multiple submitters hereditary neoplastic syndrome
p.Arg123Leu Multiple submitters hereditary neoplastic syndrome
p.Arg159Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg159Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg159Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg159Ter Multiple submitters hereditary neoplastic syndrome
p.Arg214Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg214His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg214Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg215Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg215Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg215His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg215Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg217Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg217Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg217His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg217Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg217Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg220Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg220His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg220Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg229Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg229Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg229Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg233Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg233Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg233Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg233Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg246Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg247Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg247His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg247Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg258Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg258His Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Arg258Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg258Ser Multiple submitters ⚠
p.Arg25Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg25Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg267Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg267Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg267His Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg267Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg268Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg268Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg268Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg268Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg91Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg91Ter Multiple submitters hereditary neoplastic syndrome
p.Arg94Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg94Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Arg94Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn179Lys Multiple submitters hereditary neoplastic syndrome
p.Asn238Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn238Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn266Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn266Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn26His Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn26Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Asn47Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp10Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp10Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp145Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp145Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp161Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp161Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp167Asn Multiple submitters HOXB13-related disorder ⚠
p.Asp167Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp244Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp244Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Asp244Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys100Phe Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Cys100Trp Multiple submitters hereditary neoplastic syndrome
p.Cys100Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys184Phe Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys184Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys63Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys63Ter Multiple submitters hereditary neoplastic syndrome
p.Cys63Tyr Multiple submitters hereditary neoplastic syndrome
p.Cys66Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys66Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Cys66Ter Multiple submitters hereditary neoplastic syndrome
p.Cys90Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln102Ter Multiple submitters hereditary neoplastic syndrome
p.Gln138Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln150Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln170Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln181His Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Gln181Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln185Ter Multiple submitters hereditary neoplastic syndrome
p.Gln188Arg Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Gln188Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln188Ter Multiple submitters hereditary neoplastic syndrome
p.Gln205Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln205dup Multiple submitters hereditary neoplastic syndrome
p.Gln205Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln227Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln227Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln259Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gln71Ter Multiple submitters hereditary neoplastic syndrome
p.Glu118Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu119Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu119Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu157Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu16Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu187Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu230Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu230Ter Multiple submitters hereditary neoplastic syndrome
p.Glu232Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu232Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu232Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu234Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu234Gly Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu257fs Multiple submitters hereditary neoplastic syndrome
p.Glu257Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu257Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu271Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu2Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Glu2Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly117Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly117Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly117Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly132Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly135Arg Multiple submitters hereditary neoplastic syndrome
p.Gly135Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly153Cys Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Gly153Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly156Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly176Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly177Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly17Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly17Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly17fs Multiple submitters hereditary neoplastic syndrome
p.Gly17Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly17Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly186Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly192Asp Multiple submitters hereditary neoplastic syndrome
p.Gly192Cys Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Gly192Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly204Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly204Trp Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly216Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly216Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly216Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly226Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly226Glu Multiple submitters hereditary neoplastic syndrome
p.Gly22Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly22Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly23Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly24Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly4Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly4Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly4Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly68Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly68Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly72Val Multiple submitters HOXB13-related disorder ⚠
p.Gly81Asp Multiple submitters hereditary neoplastic syndrome
p.Gly81Cys Multiple submitters hereditary neoplastic syndrome ⚠
p.Gly85Asp Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Gly85Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.His206Asp Multiple submitters hereditary neoplastic syndrome ⚠
p.His30Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.His30Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.His30Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.His36Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.His36Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.His36Pro Multiple submitters hereditary neoplastic syndrome ⚠
p.His64Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ile15Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Ile15Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ile15Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ile15Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Ile221Phe Multiple submitters hereditary neoplastic syndrome ⚠
p.Ile249Met Multiple submitters hereditary neoplastic syndrome ⚠
p.Ile260Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Ile260Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Ile260Val Multiple submitters hereditary neoplastic syndrome
p.Ile262Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Ile262Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Ile262Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu106Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu144Met Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu152Met Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu152Val Multiple submitters ⚠
p.Leu164Met Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu164Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu174Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu18Phe Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Leu228Met Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu255fs Multiple submitters hereditary neoplastic syndrome
p.Leu255Phe Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu27Met Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu33Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu51Phe Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu97Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Leu9Ter Multiple submitters hereditary neoplastic syndrome
p.Lys196fs Multiple submitters hereditary neoplastic syndrome
p.Lys218Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys218Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys218Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys225Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys239Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys239Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys243Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys245Gln Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys248Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys270Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys270Glu Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys272Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys272fs Multiple submitters hereditary neoplastic syndrome
p.Lys273Arg Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys273del Multiple submitters hereditary neoplastic syndrome
p.Lys279Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys61Asn Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys61fs Multiple submitters hereditary neoplastic syndrome
p.Lys61Met Multiple submitters hereditary neoplastic syndrome ⚠
p.Lys98Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Met140del Multiple submitters hereditary neoplastic syndrome
p.Met140Val Multiple submitters hereditary neoplastic syndrome ⚠
p.Met182Lys Multiple submitters hereditary neoplastic syndrome ⚠
p.Met182Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Met1Ile Multiple submitters hereditary neoplastic syndrome
p.Met43Ile Multiple submitters prostate cancer, hereditary, 9 ⚠
p.Phe127Tyr Multiple submitters hereditary neoplastic syndrome ⚠
p.Phe194Ile Multiple submitters hereditary neoplastic syndrome ⚠
p.Phe240Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Phe264Ser Multiple submitters hereditary neoplastic syndrome ⚠
p.Phe83Ser Multiple submitters hereditary neoplastic syndrome
p.Pro110Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Pro110Leu Multiple submitters hereditary neoplastic syndrome ⚠
p.Pro110Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Pro114Thr Multiple submitters hereditary neoplastic syndrome ⚠
p.Pro121Ala Multiple submitters hereditary neoplastic syndrome ⚠
p.Pro121Leu Multiple submitters hereditary neoplastic syndrome ⚠