Sugi Variant

Sugi Variant/HR

HR — 533 ClinVar variants

All ClinVar germline HR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 274 flagged for review →

18 Pathogenic · 3 Pathogenic/Likely pathogenic · 10 Likely pathogenic · 27 Conflicting · 59 Benign · 21 Benign/Likely benign · 67 Likely benign · 328 Uncertain significance

Full HR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 274

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 12

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 237

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 237

Predictors split 25

The independent predictors disagree with each other — read with care.

All HR variants

Pathogenic 18

Pathogenic/Likely pathogenic 3

Likely pathogenic 10

Conflicting classifications of pathogenicity 27

Benign 59

Benign/Likely benign 21

Likely benign 67

Uncertain significance 328

Showing the top 300 by review status; the full set is in the sitemap.