HRH3 — 47 ClinVar variants
All ClinVar germline HRH3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
2 Benign · 1 Benign/Likely benign · 2 Likely benign · 42 Uncertain significance
Full HRH3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HRH3 p.Ala21Val Uncertain significance Single submitter
- HRH3 p.Ala22Val Uncertain significance Single submitter
- HRH3 p.Ala236Ser Uncertain significance Single submitter
- HRH3 p.Ala284Val Uncertain significance Single submitter
- HRH3 p.Ala286Asp Uncertain significance Single submitter
- HRH3 p.Ala328Ser Uncertain significance Single submitter
- HRH3 p.Ala383Thr Uncertain significance Single submitter
- HRH3 p.Ala403Val Uncertain significance Single submitter
- HRH3 p.Arg143Trp Uncertain significance Single submitter
- HRH3 p.Arg154Trp Uncertain significance Single submitter
- HRH3 p.Arg227Lys Uncertain significance Single submitter
- HRH3 p.Arg232Gln Uncertain significance Single submitter
- HRH3 p.Arg232Trp Uncertain significance Single submitter
- HRH3 p.Arg237Gln Uncertain significance Single submitter
- HRH3 p.Arg237Gly Uncertain significance Single submitter
- HRH3 p.Arg312Lys Uncertain significance Single submitter
- HRH3 p.Arg318His Uncertain significance Single submitter
- HRH3 p.Arg336Cys Uncertain significance Single submitter
- HRH3 p.Asp7Val Uncertain significance Single submitter
- HRH3 p.Glu243Lys Uncertain significance Single submitter
- HRH3 p.Glu247Lys Uncertain significance Single submitter
- HRH3 p.Gly186Asp Uncertain significance Single submitter
- HRH3 p.Gly257Ala Uncertain significance Single submitter
- HRH3 p.Gly292Arg Uncertain significance Single submitter
- HRH3 p.Gly293Val Uncertain significance Single submitter
- HRH3 p.Gly297Val Uncertain significance Single submitter
- HRH3 p.Gly308Ser Uncertain significance Single submitter
- HRH3 p.His385Arg Uncertain significance Single submitter
- HRH3 p.Ile221Val Uncertain significance Single submitter
- HRH3 p.Pro244Leu Uncertain significance Single submitter
- HRH3 p.Pro255Leu Uncertain significance Single submitter
- HRH3 p.Ser311Leu Uncertain significance Single submitter
- HRH3 p.Thr149Met Uncertain significance Single submitter
- HRH3 p.Thr304Ile Uncertain significance Single submitter
- HRH3 p.Val214Ile Uncertain significance Single submitter
- HRH3 p.Val300Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- HRH3 p.Arg347Cys Uncertain significance Single submitter
- HRH3 p.Arg420Cys Uncertain significance Single submitter
- HRH3 p.Gly180Ala Uncertain significance Single submitter
- HRH3 p.Ser305Phe Uncertain significance Single submitter
- HRH3 p.Thr137Asn Uncertain significance Single submitter
- HRH3 p.Thr201Met Uncertain significance Single submitter
All HRH3 variants
Benign/Likely benign 1
- p.Ser405= Multiple submitters
Uncertain significance 42
- p.Ala21Val Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Ala236Ser Single submitter ⚠
- p.Ala284Val Single submitter ⚠
- p.Ala286Asp Single submitter ⚠
- p.Ala328Ser Single submitter ⚠
- p.Ala383Thr Single submitter ⚠
- p.Ala403Val Single submitter ⚠
- p.Arg143Trp Single submitter ⚠
- p.Arg154Trp Single submitter ⚠
- p.Arg227Lys Single submitter ⚠
- p.Arg232Gln Single submitter ⚠
- p.Arg232Trp Single submitter ⚠
- p.Arg237Gln Single submitter ⚠
- p.Arg237Gly Single submitter ⚠
- p.Arg312Lys Single submitter ⚠
- p.Arg318His Single submitter ⚠
- p.Arg336Cys Single submitter ⚠
- p.Arg347Cys Single submitter ⚠
- p.Arg420Cys Single submitter ⚠
- p.Asp7Val Single submitter ⚠
- p.Glu243Lys Single submitter ⚠
- p.Glu247Lys Single submitter ⚠
- p.Gly180Ala Single submitter ⚠
- p.Gly186Asp Single submitter ⚠
- p.Gly257Ala Single submitter ⚠
- p.Gly292Arg Single submitter ⚠
- p.Gly293Val Single submitter ⚠
- p.Gly297Val Single submitter ⚠
- p.Gly308Ser Single submitter ⚠
- p.His385Arg Single submitter ⚠
- p.Ile221Val Single submitter ⚠
- p.Pro244Leu Single submitter ⚠
- p.Pro255Leu Single submitter ⚠
- p.Ser305Phe Single submitter ⚠
- p.Ser311Leu Single submitter ⚠
- p.Thr137Asn Single submitter ⚠
- p.Thr149Met Single submitter ⚠
- p.Thr201Met Single submitter ⚠
- p.Thr304Ile Single submitter ⚠
- p.Val214Ile Single submitter ⚠
- p.Val300Met Single submitter ⚠