HRH4 — 58 ClinVar variants
All ClinVar germline HRH4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
5 Likely benign · 53 Uncertain significance
Full HRH4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HRH4 p.Ala143Thr Uncertain significance Single submitter
- HRH4 p.Ala176Val Uncertain significance Single submitter
- HRH4 p.Arg204His Uncertain significance Single submitter
- HRH4 p.Arg49Gln Uncertain significance Single submitter
- HRH4 p.Asn270Asp Uncertain significance Single submitter
- HRH4 p.Asn45Ser Uncertain significance Single submitter
- HRH4 p.Asp111Gly Uncertain significance Single submitter
- HRH4 p.Cys374Phe Uncertain significance Single submitter
- HRH4 p.Cys374Tyr Uncertain significance Single submitter
- HRH4 p.Gln125His Uncertain significance Single submitter
- HRH4 p.Glu243Gly Uncertain significance Single submitter
- HRH4 p.Gly161Ser Uncertain significance Single submitter
- HRH4 p.His48Arg Uncertain significance Single submitter
- HRH4 p.His75Tyr Uncertain significance Single submitter
- HRH4 p.Ile342Thr Uncertain significance Single submitter
- HRH4 p.Ile372Met Uncertain significance Single submitter
- HRH4 p.Ile59Val Uncertain significance Single submitter
- HRH4 p.Ile69Val Uncertain significance Single submitter
- HRH4 p.Ile86Phe Uncertain significance Single submitter
- HRH4 p.Leu152Arg Uncertain significance Single submitter
- HRH4 p.Leu175Val Uncertain significance Single submitter
- HRH4 p.Leu189Phe Uncertain significance Single submitter
- HRH4 p.Leu24Val Uncertain significance Single submitter
- HRH4 p.Leu308Val Uncertain significance Single submitter
- HRH4 p.Leu357Trp Uncertain significance Single submitter
- HRH4 p.Lys44Glu Uncertain significance Single submitter
- HRH4 p.Met260Thr Uncertain significance Single submitter
- HRH4 p.Met276Arg Uncertain significance Single submitter
- HRH4 p.Met276Lys Uncertain significance Single submitter
- HRH4 p.Phe180Ser Uncertain significance Single submitter
- HRH4 p.Phe193Ser Uncertain significance Single submitter
- HRH4 p.Phe312Val Uncertain significance Single submitter
- HRH4 p.Pro355Leu Uncertain significance Single submitter
- HRH4 p.Ser109Gly Uncertain significance Single submitter
- HRH4 p.Ser117Thr Uncertain significance Single submitter
- HRH4 p.Ser257Gly Uncertain significance Single submitter
- HRH4 p.Ser262Cys Uncertain significance Single submitter
- HRH4 p.Thr14Ile Uncertain significance Single submitter
- HRH4 p.Thr76Ala Uncertain significance Single submitter
- HRH4 p.Thr76Arg Uncertain significance Single submitter
- HRH4 p.Thr93Ala Uncertain significance Single submitter
- HRH4 p.Tyr319Cys Uncertain significance Single submitter
- HRH4 p.Tyr340Cys Uncertain significance Single submitter
- HRH4 p.Val141Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- HRH4 p.Ala368Thr Uncertain significance Single submitter
- HRH4 p.Arg15Cys Uncertain significance Single submitter
- HRH4 p.Arg15His Uncertain significance Single submitter
- HRH4 p.Gly310Arg Uncertain significance Single submitter
- HRH4 p.His288Pro Uncertain significance Single submitter
- HRH4 p.Phe369Leu Uncertain significance Single submitter
- HRH4 p.Ser115Leu Uncertain significance Single submitter
- HRH4 p.Thr7Ile Uncertain significance Single submitter
- HRH4 p.Val187Asp Uncertain significance Single submitter
All HRH4 variants
Likely benign 5
- p.Ala218Ser Single submitter
- p.Ile375Val Single submitter
- p.Lys266Gln Single submitter
- p.Ser241Leu Single submitter
- p.Thr76Met Single submitter
Uncertain significance 53
- p.Ala143Thr Single submitter ⚠
- p.Ala176Val Single submitter ⚠
- p.Ala368Thr Single submitter ⚠
- p.Arg15Cys Single submitter ⚠
- p.Arg15His Single submitter ⚠
- p.Arg204His Single submitter ⚠
- p.Arg49Gln Single submitter ⚠
- p.Asn270Asp Single submitter ⚠
- p.Asn45Ser Single submitter ⚠
- p.Asp111Gly Single submitter ⚠
- p.Cys374Phe Single submitter ⚠
- p.Cys374Tyr Single submitter ⚠
- p.Gln125His Single submitter ⚠
- p.Glu243Gly Single submitter ⚠
- p.Gly161Ser Single submitter ⚠
- p.Gly310Arg Single submitter ⚠
- p.His288Pro Single submitter ⚠
- p.His48Arg Single submitter ⚠
- p.His75Tyr Single submitter ⚠
- p.Ile342Thr Single submitter ⚠
- p.Ile372Met Single submitter ⚠
- p.Ile59Val Single submitter ⚠
- p.Ile69Val Single submitter ⚠
- p.Ile86Phe Single submitter ⚠
- p.Leu152Arg Single submitter ⚠
- p.Leu175Val Single submitter ⚠
- p.Leu189Phe Single submitter ⚠
- p.Leu24Val Single submitter ⚠
- p.Leu308Val Single submitter ⚠
- p.Leu357Trp Single submitter ⚠
- p.Lys44Glu Single submitter ⚠
- p.Met260Thr Single submitter ⚠
- p.Met276Arg Single submitter ⚠
- p.Met276Lys Single submitter ⚠
- p.Phe180Ser Single submitter ⚠
- p.Phe193Ser Single submitter ⚠
- p.Phe312Val Single submitter ⚠
- p.Phe369Leu Single submitter ⚠
- p.Pro355Leu Single submitter ⚠
- p.Ser109Gly Single submitter ⚠
- p.Ser115Leu Single submitter ⚠
- p.Ser117Thr Single submitter ⚠
- p.Ser257Gly Single submitter ⚠
- p.Ser262Cys Single submitter ⚠
- p.Thr14Ile Single submitter ⚠
- p.Thr76Ala Single submitter ⚠
- p.Thr76Arg Single submitter ⚠
- p.Thr7Ile Single submitter ⚠
- p.Thr93Ala Single submitter ⚠
- p.Tyr319Cys Single submitter ⚠
- p.Tyr340Cys Single submitter ⚠
- p.Val141Leu Single submitter ⚠
- p.Val187Asp Single submitter ⚠