HSF1 — 74 ClinVar variants
All ClinVar germline HSF1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
2 Benign · 6 Likely benign · 66 Uncertain significance
Full HSF1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HSF1 p.Ala160Thr Uncertain significance Single submitter
- HSF1 p.Ala313Glu Uncertain significance Single submitter
- HSF1 p.Ala343Thr Uncertain significance Single submitter
- HSF1 p.Ala437Thr Uncertain significance Single submitter
- HSF1 p.Arg133Cys Uncertain significance Single submitter
- HSF1 p.Arg296Cys Uncertain significance Single submitter
- HSF1 p.Arg309Gln Uncertain significance Single submitter
- HSF1 p.Arg309Trp Uncertain significance Single submitter
- HSF1 p.Arg336Leu Uncertain significance Single submitter
- HSF1 p.Asn42Thr Uncertain significance Single submitter
- HSF1 p.Asp32Asn Uncertain significance Single submitter
- HSF1 p.Asp332Asn Uncertain significance Single submitter
- HSF1 p.Asp433Asn Uncertain significance Single submitter
- HSF1 p.Asp482His Uncertain significance Single submitter
- HSF1 p.Gln51Pro Uncertain significance Single submitter
- HSF1 p.Glu299Lys Uncertain significance Single submitter
- HSF1 p.Glu312Asp Uncertain significance Single submitter
- HSF1 p.Glu455Asp Uncertain significance Single submitter
- HSF1 p.Glu496Asp Uncertain significance Single submitter
- HSF1 p.Glu508Lys Uncertain significance Single submitter
- HSF1 p.Gly316Arg Uncertain significance Single submitter
- HSF1 p.Gly479Ala Uncertain significance Single submitter
- HSF1 p.Gly484Arg Uncertain significance Single submitter
- HSF1 p.Ile35Thr Uncertain significance Single submitter
- HSF1 p.Leu417Val Uncertain significance Single submitter
- HSF1 p.Leu465Val Uncertain significance Single submitter
- HSF1 p.Lys62Arg Uncertain significance Single submitter
- HSF1 p.Pro29Leu Uncertain significance Single submitter
- HSF1 p.Pro302Leu Uncertain significance Single submitter
- HSF1 p.Pro304Leu Uncertain significance Single submitter
- HSF1 p.Pro308Ser Uncertain significance Single submitter
- HSF1 p.Pro318Leu Uncertain significance Single submitter
- HSF1 p.Pro340Leu Uncertain significance Single submitter
- HSF1 p.Pro340Ser Uncertain significance Single submitter
- HSF1 p.Pro361Leu Uncertain significance Single submitter
- HSF1 p.Pro370Arg Uncertain significance Single submitter
- HSF1 p.Pro425Arg Uncertain significance Single submitter
- HSF1 p.Pro478Ala Uncertain significance Single submitter
- HSF1 p.Ser226Ile Uncertain significance Single submitter
- HSF1 p.Ser251Gly Uncertain significance Single submitter
- HSF1 p.Ser385Cys Uncertain significance Single submitter
- HSF1 p.Ser403Arg Uncertain significance Single submitter
- HSF1 p.Ser408Gly Uncertain significance Single submitter
- HSF1 p.Ser412Asn Uncertain significance Single submitter
- HSF1 p.Ser43Arg Uncertain significance Single submitter
- HSF1 p.Ser444Phe Uncertain significance Single submitter
- HSF1 p.Ser458Asn Uncertain significance Single submitter
- HSF1 p.Thr355Met Uncertain significance Single submitter
- HSF1 p.Thr423Ser Uncertain significance Single submitter
- HSF1 p.Val186Ile Uncertain significance Single submitter
- HSF1 p.Val376Ile Uncertain significance Single submitter
- HSF1 p.Val424Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- HSF1 p.Ala173Thr Uncertain significance Single submitter
- HSF1 p.Ala470Glu Uncertain significance Single submitter
- HSF1 p.Ala67Val Uncertain significance Single submitter
- HSF1 p.Arg106His Uncertain significance Single submitter
- HSF1 p.Arg227Gln Uncertain significance Single submitter
- HSF1 p.Ile190Val Uncertain significance Single submitter
- HSF1 p.Met154Thr Uncertain significance Single submitter
- HSF1 p.Met161Val Uncertain significance Single submitter
- HSF1 p.Ser13Arg Uncertain significance Single submitter
- HSF1 p.Ser279Cys Uncertain significance Single submitter
- HSF1 p.Val119Gly Uncertain significance Single submitter
All HSF1 variants
Likely benign 6
- p.Gly505Ser Single submitter
- p.Leu379= Single submitter
- p.Pro365Leu Single submitter
- p.Ser237= Single submitter
- p.Ser249Gly Single submitter
- p.Ser320= Single submitter
Uncertain significance 66
- p.Ala160Thr Single submitter ⚠
- p.Ala173Thr Single submitter ⚠
- p.Ala313Glu Single submitter ⚠
- p.Ala343Thr Single submitter ⚠
- p.Ala437Thr Single submitter ⚠
- p.Ala470Glu Single submitter ⚠
- p.Ala67Val Single submitter ⚠
- p.Arg106His Single submitter ⚠
- p.Arg133Cys Single submitter ⚠
- p.Arg227Gln Single submitter ⚠
- p.Arg296Cys Single submitter ⚠
- p.Arg309Gln Single submitter ⚠
- p.Arg309Trp Single submitter ⚠
- p.Arg336Leu Single submitter ⚠
- p.Asn42Thr Single submitter ⚠
- p.Asp135Tyr Single submitter
- p.Asp32Asn Single submitter ⚠
- p.Asp332Asn Single submitter ⚠
- p.Asp433Asn Single submitter ⚠
- p.Asp482His Single submitter ⚠
- p.Gln51Pro Single submitter ⚠
- p.Glu299Lys Single submitter ⚠
- p.Glu312Asp Single submitter ⚠
- p.Glu455Asp Single submitter ⚠
- p.Glu496Asp Single submitter ⚠
- p.Glu508Lys Single submitter ⚠
- p.Gly316Arg Single submitter ⚠
- p.Gly479Ala Single submitter ⚠
- p.Gly484Arg Single submitter ⚠
- p.Ile190Val Single submitter ⚠
- p.Ile35Thr Single submitter ⚠
- p.Leu417Val Single submitter ⚠
- p.Leu465Val Single submitter ⚠
- p.Leu488Pro Single submitter
- p.Lys62Arg Single submitter ⚠
- p.Met154Thr Single submitter ⚠
- p.Met161Val Single submitter ⚠
- p.Pro29Leu Single submitter ⚠
- p.Pro302Leu Single submitter ⚠
- p.Pro304Leu Single submitter ⚠
- p.Pro308Ser Single submitter ⚠
- p.Pro318Leu Single submitter ⚠
- p.Pro327Ser Single submitter
- p.Pro340Leu Single submitter ⚠
- p.Pro340Ser Single submitter ⚠
- p.Pro361Leu Single submitter ⚠
- p.Pro370Arg Single submitter ⚠
- p.Pro425Arg Single submitter ⚠
- p.Pro478Ala Single submitter ⚠
- p.Ser13Arg Single submitter ⚠
- p.Ser226Ile Single submitter ⚠
- p.Ser251Gly Single submitter ⚠
- p.Ser279Cys Single submitter ⚠
- p.Ser385Cys Single submitter ⚠
- p.Ser403Arg Single submitter ⚠
- p.Ser408Gly Single submitter ⚠
- p.Ser412Asn Single submitter ⚠
- p.Ser43Arg Single submitter ⚠
- p.Ser444Phe Single submitter ⚠
- p.Ser458Asn Single submitter ⚠
- p.Thr355Met Single submitter ⚠
- p.Thr423Ser Single submitter ⚠
- p.Val119Gly Single submitter ⚠
- p.Val186Ile Single submitter ⚠
- p.Val376Ile Single submitter ⚠
- p.Val424Leu Single submitter ⚠