HSP90B1 — 80 ClinVar variants
All ClinVar germline HSP90B1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
1 Benign · 2 Likely benign · 77 Uncertain significance
Full HSP90B1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HSP90B1 p.Ala21Thr Uncertain significance Single submitter
- HSP90B1 p.Ala298Thr Uncertain significance Single submitter
- HSP90B1 p.Ala734Ser Uncertain significance Single submitter
- HSP90B1 p.Ala798Pro Uncertain significance Single submitter
- HSP90B1 p.Arg102Gly Uncertain significance Single submitter
- HSP90B1 p.Arg243Trp Uncertain significance Single submitter
- HSP90B1 p.Arg466His Uncertain significance Single submitter
- HSP90B1 p.Arg505Cys Uncertain significance Single submitter
- HSP90B1 p.Arg557Gln Uncertain significance Single submitter
- HSP90B1 p.Arg660Gly Uncertain significance Single submitter
- HSP90B1 p.Arg67Lys Uncertain significance Single submitter
- HSP90B1 p.Arg699Gln Uncertain significance Single submitter
- HSP90B1 p.Arg724Gln Uncertain significance Single submitter
- HSP90B1 p.Asn124Asp Uncertain significance Single submitter
- HSP90B1 p.Asn176Ser Uncertain significance Single submitter
- HSP90B1 p.Asn228Ser Uncertain significance Single submitter
- HSP90B1 p.Asp22Glu Uncertain significance Single submitter
- HSP90B1 p.Asp307Gly Uncertain significance Single submitter
- HSP90B1 p.Asp407Tyr Uncertain significance Single submitter
- HSP90B1 p.Asp440Gly Uncertain significance Single submitter
- HSP90B1 p.Gln182Lys Uncertain significance Single submitter
- HSP90B1 p.Glu327Gly Uncertain significance Single submitter
- HSP90B1 p.Glu449Lys Uncertain significance Single submitter
- HSP90B1 p.Glu616Gln Uncertain significance Single submitter
- HSP90B1 p.Glu71Asp Uncertain significance Single submitter
- HSP90B1 p.Glu768Lys Uncertain significance Single submitter
- HSP90B1 p.Glu790Gln Uncertain significance Single submitter
- HSP90B1 p.Ile342Val Uncertain significance Single submitter
- HSP90B1 p.Ile538Met Uncertain significance Single submitter
- HSP90B1 p.Leu627Phe Uncertain significance Single submitter
- HSP90B1 p.Lys114Glu Uncertain significance Single submitter
- HSP90B1 p.Lys547Arg Uncertain significance Single submitter
- HSP90B1 p.Lys72Asn Uncertain significance Single submitter
- HSP90B1 p.Lys754Thr Uncertain significance Single submitter
- HSP90B1 p.Lys75Arg Uncertain significance Single submitter
- HSP90B1 p.Lys794Gln Uncertain significance Single submitter
- HSP90B1 p.Met662Thr Uncertain significance Single submitter
- HSP90B1 p.Met782Val Uncertain significance Single submitter
- HSP90B1 p.Pro278Thr Uncertain significance Single submitter
- HSP90B1 p.Ser680Thr Uncertain significance Single submitter
- HSP90B1 p.Ser73Trp Uncertain significance Single submitter
- HSP90B1 p.Thr171Ala Uncertain significance Single submitter
- HSP90B1 p.Thr188Ala Uncertain significance Single submitter
- HSP90B1 p.Thr245Met Uncertain significance Single submitter
- HSP90B1 p.Thr675Ala Uncertain significance Single submitter
- HSP90B1 p.Thr722Met Uncertain significance Single submitter
- HSP90B1 p.Thr766Arg Uncertain significance Single submitter
- HSP90B1 p.Trp621Cys Uncertain significance Single submitter
- HSP90B1 p.Tyr735Cys Uncertain significance Single submitter
- HSP90B1 p.Val25Ala Uncertain significance Single submitter
- HSP90B1 p.Val268Ile Uncertain significance Single submitter
- HSP90B1 p.Val326Ile Uncertain significance Single submitter
- HSP90B1 p.Val6Leu Uncertain significance Single submitter
- HSP90B1 p.Val716Ile Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- HSP90B1 p.Arg608Cys Uncertain significance Single submitter
- HSP90B1 p.Arg608His Uncertain significance Single submitter
- HSP90B1 p.Arg700Gln Uncertain significance Single submitter
- HSP90B1 p.Asn217Ser Uncertain significance Single submitter
- HSP90B1 p.Asp23Tyr Uncertain significance Single submitter
- HSP90B1 p.Asp399Asn Uncertain significance Single submitter
- HSP90B1 p.Asp482Tyr Uncertain significance Single submitter
- HSP90B1 p.Asp59Glu Uncertain significance Single submitter
- HSP90B1 p.Asp752Val Uncertain significance Single submitter
- HSP90B1 p.Glu302Val Uncertain significance Single submitter
- HSP90B1 p.Glu313Lys Uncertain significance Single submitter
- HSP90B1 p.Lys360Arg Uncertain significance Single submitter
- HSP90B1 p.Lys463Arg Uncertain significance Single submitter
- HSP90B1 p.Lys671Glu Uncertain significance Single submitter
- HSP90B1 p.Phe554Leu Uncertain significance Single submitter
- HSP90B1 p.Pro763Arg Uncertain significance Single submitter
- HSP90B1 p.Ser256Phe Uncertain significance Single submitter
- HSP90B1 p.Thr522Ala Uncertain significance Single submitter
- HSP90B1 p.Tyr735His Uncertain significance Single submitter
All HSP90B1 variants
Benign 1
- p.Ser73= Multiple submitters
Likely benign 2
- p.Ala767Thr Single submitter
- p.Leu713= Single submitter
Uncertain significance 77
- p.Ala21Thr Single submitter ⚠
- p.Ala298Thr Single submitter ⚠
- p.Ala734Ser Single submitter ⚠
- p.Ala798Pro Single submitter ⚠
- p.Arg102Gly Single submitter ⚠
- p.Arg243Trp Single submitter ⚠
- p.Arg466His Single submitter ⚠
- p.Arg505Cys Single submitter ⚠
- p.Arg557Gln Single submitter ⚠
- p.Arg608Cys Single submitter ⚠
- p.Arg608His Single submitter ⚠
- p.Arg660Gly Single submitter ⚠
- p.Arg67Lys Single submitter ⚠
- p.Arg699Gln Single submitter ⚠
- p.Arg700Gln Single submitter ⚠
- p.Arg724Gln Single submitter ⚠
- p.Asn124Asp Single submitter ⚠
- p.Asn176Ser Single submitter ⚠
- p.Asn217Ser Single submitter ⚠
- p.Asn228Ser Single submitter ⚠
- p.Asp22Glu Single submitter ⚠
- p.Asp23Tyr Single submitter ⚠
- p.Asp307Gly Single submitter ⚠
- p.Asp399Asn Single submitter ⚠
- p.Asp407Tyr Single submitter ⚠
- p.Asp440Gly Single submitter ⚠
- p.Asp482Tyr Single submitter ⚠
- p.Asp59Glu Single submitter ⚠
- p.Asp752Val Single submitter ⚠
- p.Gln182Lys Single submitter ⚠
- p.Glu302Val Single submitter ⚠
- p.Glu313Lys Single submitter ⚠
- p.Glu327Gly Single submitter ⚠
- p.Glu449Lys Single submitter ⚠
- p.Glu533Lys Single submitter
- p.Glu616Gln Single submitter ⚠
- p.Glu71Asp Single submitter ⚠
- p.Glu768Lys Single submitter ⚠
- p.Glu790Gln Single submitter ⚠
- p.His215Tyr Single submitter
- p.Ile342Val Single submitter ⚠
- p.Ile538Met Single submitter ⚠
- p.Leu627Phe Single submitter ⚠
- p.Lys114Glu Single submitter ⚠
- p.Lys360Arg Single submitter ⚠
- p.Lys463Arg Single submitter ⚠
- p.Lys547Arg Single submitter ⚠
- p.Lys671Glu Single submitter ⚠
- p.Lys72Asn Single submitter ⚠
- p.Lys754Thr Single submitter ⚠
- p.Lys75Arg Single submitter ⚠
- p.Lys794Gln Single submitter ⚠
- p.Met336Thr Single submitter
- p.Met662Thr Single submitter ⚠
- p.Met782Val Single submitter ⚠
- p.Phe554Leu Single submitter ⚠
- p.Pro278Thr Single submitter ⚠
- p.Pro763Arg Single submitter ⚠
- p.Ser256Phe Single submitter ⚠
- p.Ser680Thr Single submitter ⚠
- p.Ser73Trp Single submitter ⚠
- p.Thr171Ala Single submitter ⚠
- p.Thr188Ala Single submitter ⚠
- p.Thr245Met Single submitter ⚠
- p.Thr522Ala Single submitter ⚠
- p.Thr675Ala Single submitter ⚠
- p.Thr722Met Single submitter ⚠
- p.Thr766Arg Single submitter ⚠
- p.Trp621Cys Single submitter ⚠
- p.Tyr735Cys Single submitter ⚠
- p.Tyr735His Single submitter ⚠
- p.Val25Ala Single submitter ⚠
- p.Val268Ile Single submitter ⚠
- p.Val326Ile Single submitter ⚠
- p.Val528Leu Single submitter
- p.Val6Leu Single submitter ⚠
- p.Val716Ile Single submitter ⚠