HSPA2 — 53 ClinVar variants
All ClinVar germline HSPA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
3 Benign · 50 Uncertain significance
Full HSPA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HSPA2 p.Ala180Thr Uncertain significance Single submitter
- HSPA2 p.Ala381Thr Uncertain significance Single submitter
- HSPA2 p.Ala44Thr Uncertain significance Single submitter
- HSPA2 p.Ala7Ser Uncertain significance Single submitter
- HSPA2 p.Arg239Leu Uncertain significance Single submitter
- HSPA2 p.Arg265Leu Uncertain significance Single submitter
- HSPA2 p.Arg304Leu Uncertain significance Single submitter
- HSPA2 p.Arg562Lys Uncertain significance Single submitter
- HSPA2 p.Asn169Ser Uncertain significance Single submitter
- HSPA2 p.Asn551Thr Uncertain significance Single submitter
- HSPA2 p.Asn582Ser Uncertain significance Single submitter
- HSPA2 p.Gln523Arg Uncertain significance Single submitter
- HSPA2 p.Glu361Lys Uncertain significance Single submitter
- HSPA2 p.Glu594Lys Uncertain significance Single submitter
- HSPA2 p.Gly193Asp Uncertain significance Single submitter
- HSPA2 p.Gly466Glu Uncertain significance Single submitter
- HSPA2 p.Gly473Arg Uncertain significance Single submitter
- HSPA2 p.Gly53Cys Uncertain significance Single submitter
- HSPA2 p.Gly631Arg Uncertain significance Single submitter
- HSPA2 p.Ile256Val Uncertain significance Single submitter
- HSPA2 p.Lys598Arg Uncertain significance Single submitter
- HSPA2 p.Met452Leu Uncertain significance Single submitter
- HSPA2 p.Met589Thr Uncertain significance Single submitter
- HSPA2 p.Phe115Leu Uncertain significance Single submitter
- HSPA2 p.Phe305Leu Uncertain significance Single submitter
- HSPA2 p.Pro102Ser Uncertain significance Single submitter
- HSPA2 p.Pro415Ala Uncertain significance Single submitter
- HSPA2 p.Ser142Asn Uncertain significance Single submitter
- HSPA2 p.Thr112Ser Uncertain significance Single submitter
- HSPA2 p.Thr114Asn Uncertain significance Single submitter
- HSPA2 p.Thr164Ile Uncertain significance Single submitter
- HSPA2 p.Thr344Ile Uncertain significance Single submitter
- HSPA2 p.Tyr297Asn Uncertain significance Single submitter
- HSPA2 p.Tyr548His Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- HSPA2 p.Ala470Ser Uncertain significance Single submitter
- HSPA2 p.Arg527Trp Uncertain significance Single submitter
- HSPA2 p.Asp386Asn Uncertain significance Single submitter
- HSPA2 p.Asp393Glu Uncertain significance Single submitter
- HSPA2 p.Glu107Gly Uncertain significance Single submitter
- HSPA2 p.Glu318Gln Uncertain significance Single submitter
- HSPA2 p.Gly620Cys Uncertain significance Single submitter
- HSPA2 p.Ile145Leu Uncertain significance Single submitter
- HSPA2 p.Lys196Asn Uncertain significance Single submitter
- HSPA2 p.Lys72Asn Uncertain significance Single submitter
- HSPA2 p.Thr114Ile Uncertain significance Single submitter
- HSPA2 p.Thr298Met Uncertain significance Single submitter
All HSPA2 variants
Uncertain significance 50
- p.Ala180Thr Single submitter ⚠
- p.Ala381Thr Single submitter ⚠
- p.Ala44Thr Single submitter ⚠
- p.Ala470Ser Single submitter ⚠
- p.Ala7Ser Single submitter ⚠
- p.Arg239Leu Single submitter ⚠
- p.Arg265Leu Single submitter ⚠
- p.Arg304Leu Single submitter ⚠
- p.Arg527Trp Single submitter ⚠
- p.Arg562Lys Single submitter ⚠
- p.Asn169Ser Single submitter ⚠
- p.Asn551Thr Single submitter ⚠
- p.Asn582Ser Single submitter ⚠
- p.Asp386Asn Single submitter ⚠
- p.Asp393Glu Single submitter ⚠
- p.Gln523Arg Single submitter ⚠
- p.Glu107Gly Single submitter ⚠
- p.Glu318Gln Single submitter ⚠
- p.Glu361Lys Single submitter ⚠
- p.Glu591Lys Single submitter
- p.Glu594Lys Single submitter ⚠
- p.Gly193Asp Single submitter ⚠
- p.Gly466Glu Single submitter ⚠
- p.Gly473Arg Single submitter ⚠
- p.Gly53Cys Single submitter ⚠
- p.Gly620Cys Single submitter ⚠
- p.Gly631Arg Single submitter ⚠
- p.Ile145Leu Single submitter ⚠
- p.Ile256Val Single submitter ⚠
- p.Lys196Asn Single submitter ⚠
- p.Lys418Glu Single submitter
- p.Lys461Glu Single submitter
- p.Lys598Arg Single submitter ⚠
- p.Lys72Asn Single submitter ⚠
- p.Met452Leu Single submitter ⚠
- p.Met589Thr Single submitter ⚠
- p.Phe115Leu Single submitter ⚠
- p.Phe305Leu Single submitter ⚠
- p.Pro102Ser Single submitter ⚠
- p.Pro415Ala Single submitter ⚠
- p.Ser142Asn Single submitter ⚠
- p.Thr112Ser Single submitter ⚠
- p.Thr114Asn Single submitter ⚠
- p.Thr114Ile Single submitter ⚠
- p.Thr164Ile Single submitter ⚠
- p.Thr298Met Single submitter ⚠
- p.Thr316Ser Single submitter
- p.Thr344Ile Single submitter ⚠
- p.Tyr297Asn Single submitter ⚠
- p.Tyr548His Single submitter ⚠