HSPA4 — 89 ClinVar variants
All ClinVar germline HSPA4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
7 Benign · 1 Benign/Likely benign · 4 Likely benign · 77 Uncertain significance
Full HSPA4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HSPA4 p.Ala151Val Uncertain significance Single submitter
- HSPA4 p.Ala426Val Uncertain significance Single submitter
- HSPA4 p.Ala825Val Uncertain significance Single submitter
- HSPA4 p.Arg614Trp Uncertain significance Single submitter
- HSPA4 p.Asn311Ser Uncertain significance Single submitter
- HSPA4 p.Asn739Lys Uncertain significance Single submitter
- HSPA4 p.Asn747Asp Uncertain significance Single submitter
- HSPA4 p.Asn753Ser Uncertain significance Single submitter
- HSPA4 p.Asp558Asn Uncertain significance Single submitter
- HSPA4 p.Asp654Gly Uncertain significance Single submitter
- HSPA4 p.Asp721Tyr Uncertain significance Single submitter
- HSPA4 p.Gln523Glu Uncertain significance Single submitter
- HSPA4 p.Gln690Arg Uncertain significance Single submitter
- HSPA4 p.Gln707Pro Uncertain significance Single submitter
- HSPA4 p.Gln820His Uncertain significance Single submitter
- HSPA4 p.Glu532Asp Uncertain significance Single submitter
- HSPA4 p.Glu627Asp Uncertain significance Single submitter
- HSPA4 p.Glu767Asp Uncertain significance Single submitter
- HSPA4 p.Glu795Gln Uncertain significance Single submitter
- HSPA4 p.Gly413Trp Uncertain significance Single submitter
- HSPA4 p.Gly72Arg Uncertain significance Single submitter
- HSPA4 p.Gly821Ser Uncertain significance Single submitter
- HSPA4 p.Ile581Val Uncertain significance Single submitter
- HSPA4 p.Ile687Val Uncertain significance Single submitter
- HSPA4 p.Ile713Val Uncertain significance Single submitter
- HSPA4 p.Ile839Val Uncertain significance Single submitter
- HSPA4 p.Leu170Phe Uncertain significance Single submitter
- HSPA4 p.Leu757Phe Uncertain significance Single submitter
- HSPA4 p.Leu87Phe Uncertain significance Single submitter
- HSPA4 p.Lys221Glu Uncertain significance Single submitter
- HSPA4 p.Lys388Arg Uncertain significance Single submitter
- HSPA4 p.Lys437Glu Uncertain significance Single submitter
- HSPA4 p.Lys557Arg Uncertain significance Single submitter
- HSPA4 p.Lys704Arg Uncertain significance Single submitter
- HSPA4 p.Lys719Arg Uncertain significance Single submitter
- HSPA4 p.Lys754Glu Uncertain significance Single submitter
- HSPA4 p.Met106Leu Uncertain significance Single submitter
- HSPA4 p.Met171Leu Uncertain significance Single submitter
- HSPA4 p.Met561Thr Uncertain significance Single submitter
- HSPA4 p.Met742Val Uncertain significance Single submitter
- HSPA4 p.Pro195Arg Uncertain significance Single submitter
- HSPA4 p.Pro401Ser Uncertain significance Single submitter
- HSPA4 p.Pro792Thr Uncertain significance Single submitter
- HSPA4 p.Pro815Ser Uncertain significance Single submitter
- HSPA4 p.Ser323Arg Uncertain significance Single submitter
- HSPA4 p.Ser355Gly Uncertain significance Single submitter
- HSPA4 p.Ser384Leu Uncertain significance Single submitter
- HSPA4 p.Ser40Ala Uncertain significance Single submitter
- HSPA4 p.Ser828Leu Uncertain significance Single submitter
- HSPA4 p.Thr114Ala Uncertain significance Single submitter
- HSPA4 p.Thr114Ile Uncertain significance Single submitter
- HSPA4 p.Thr229Met Uncertain significance Single submitter
- HSPA4 p.Thr551Ile Uncertain significance Single submitter
- HSPA4 p.Thr649Ala Uncertain significance Single submitter
- HSPA4 p.Trp587Arg Uncertain significance Single submitter
- HSPA4 p.Tyr597His Uncertain significance Single submitter
- HSPA4 p.Val398Ile Uncertain significance Single submitter
- HSPA4 p.Val577Met Uncertain significance Single submitter
- HSPA4 p.Val621Ala Uncertain significance Single submitter
- HSPA4 p.Val64Ala Uncertain significance Single submitter
- HSPA4 p.Val806Met Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- HSPA4 p.Pro696Ser Benign/Likely benign Multiple submitters
- HSPA4 p.Arg483Gln Uncertain significance Single submitter
- HSPA4 p.Asn86Asp Uncertain significance Single submitter
- HSPA4 p.Gly359Ala Uncertain significance Single submitter
- HSPA4 p.Gly413Arg Uncertain significance Single submitter
- HSPA4 p.Pro453Leu Uncertain significance Single submitter
- HSPA4 p.Ser421Cys Uncertain significance Single submitter
- HSPA4 p.Ser474Cys Uncertain significance Single submitter
- HSPA4 p.Ser496Phe Uncertain significance Single submitter
- HSPA4 p.Ser76Phe Uncertain significance Single submitter
- HSPA4 p.Thr576Ile Uncertain significance Single submitter
- HSPA4 p.Val431Ala Uncertain significance Single submitter
All HSPA4 variants
Benign 7
- c.1651-10A>G Single submitter
- c.664-4T>A Single submitter
- p.Ala151= Single submitter
- p.Asp32= Single submitter
- p.Leu276= Single submitter
- p.Thr649Ser Single submitter
- p.Val198= Single submitter
Benign/Likely benign 1
- p.Pro696Ser Multiple submitters ⚠
Likely benign 4
- p.Ala176= Single submitter
- p.Glu611= Single submitter
- p.Thr104Lys Single submitter
- p.Thr778Ile Single submitter
Uncertain significance 77
- p.Ala151Val Single submitter ⚠
- p.Ala426Val Single submitter ⚠
- p.Ala825Val Single submitter ⚠
- p.Arg316Ile Single submitter
- p.Arg483Gln Single submitter ⚠
- p.Arg614Trp Single submitter ⚠
- p.Asn311Ser Single submitter ⚠
- p.Asn739Lys Single submitter ⚠
- p.Asn747Asp Single submitter ⚠
- p.Asn753Ser Single submitter ⚠
- p.Asn86Asp Single submitter ⚠
- p.Asp558Asn Single submitter ⚠
- p.Asp654Gly Single submitter ⚠
- p.Asp721Tyr Single submitter ⚠
- p.Gln523Glu Single submitter ⚠
- p.Gln690Arg Single submitter ⚠
- p.Gln707Pro Single submitter ⚠
- p.Gln820His Single submitter ⚠
- p.Glu532Asp Single submitter ⚠
- p.Glu627Asp Single submitter ⚠
- p.Glu767Asp Single submitter ⚠
- p.Glu795Gln Single submitter ⚠
- p.Gly249Trp Single submitter
- p.Gly359Ala Single submitter ⚠
- p.Gly413Arg Single submitter ⚠
- p.Gly413Trp Single submitter ⚠
- p.Gly72Arg Single submitter ⚠
- p.Gly821Ser Single submitter ⚠
- p.Ile581Val Single submitter ⚠
- p.Ile687Val Single submitter ⚠
- p.Ile713Val Single submitter ⚠
- p.Ile839Val Single submitter ⚠
- p.Leu170Phe Single submitter ⚠
- p.Leu757Phe Single submitter ⚠
- p.Leu87Phe Single submitter ⚠
- p.Lys221Glu Single submitter ⚠
- p.Lys388Arg Single submitter ⚠
- p.Lys437Glu Single submitter ⚠
- p.Lys557Arg Single submitter ⚠
- p.Lys704Arg Single submitter ⚠
- p.Lys719Arg Single submitter ⚠
- p.Lys754Glu Single submitter ⚠
- p.Met106Leu Single submitter ⚠
- p.Met171Leu Single submitter ⚠
- p.Met277Leu Single submitter
- p.Met561Thr Single submitter ⚠
- p.Met742Val Single submitter ⚠
- p.Pro195Arg Single submitter ⚠
- p.Pro401Ser Single submitter ⚠
- p.Pro453Leu Single submitter ⚠
- p.Pro792Thr Single submitter ⚠
- p.Pro815Ser Single submitter ⚠
- p.Ser323Arg Single submitter ⚠
- p.Ser355Gly Single submitter ⚠
- p.Ser384Leu Single submitter ⚠
- p.Ser40Ala Single submitter ⚠
- p.Ser421Cys Single submitter ⚠
- p.Ser474Cys Single submitter ⚠
- p.Ser496Phe Single submitter ⚠
- p.Ser76Phe Single submitter ⚠
- p.Ser828Leu Single submitter ⚠
- p.Thr114Ala Single submitter ⚠
- p.Thr114Ile Single submitter ⚠
- p.Thr229Met Single submitter ⚠
- p.Thr551Ile Single submitter ⚠
- p.Thr576Ile Single submitter ⚠
- p.Thr649Ala Single submitter ⚠
- p.Trp587Arg Single submitter ⚠
- p.Tyr435Cys Single submitter
- p.Tyr597His Single submitter ⚠
- p.Tyr723Cys Single submitter
- p.Val398Ile Single submitter ⚠
- p.Val431Ala Single submitter ⚠
- p.Val577Met Single submitter ⚠
- p.Val621Ala Single submitter ⚠
- p.Val64Ala Single submitter ⚠
- p.Val806Met Single submitter ⚠