HSPB2 — 25 ClinVar variants
All ClinVar germline HSPB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
1 Benign/Likely benign · 1 Likely benign · 23 Uncertain significance
Full HSPB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HSPB2 p.Ala178Thr Uncertain significance Single submitter
- HSPB2 p.Ala62Thr Uncertain significance Single submitter
- HSPB2 p.Arg115Gln Uncertain significance Single submitter
- HSPB2 p.Arg115Pro Uncertain significance Single submitter
- HSPB2 p.Glu181Lys Uncertain significance Single submitter
- HSPB2 p.His152Arg Uncertain significance Single submitter
- HSPB2 p.Pro104Ser Uncertain significance Single submitter
- HSPB2 p.Pro124Thr Uncertain significance Single submitter
- HSPB2 p.Tyr121His Uncertain significance Single submitter
- HSPB2 p.Val113Met Uncertain significance Single submitter
- HSPB2 p.Val88Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- HSPB2 p.Arg102Trp Uncertain significance Single submitter
- HSPB2 p.Arg106His Uncertain significance Single submitter
- HSPB2 p.Arg4Ser Uncertain significance Single submitter
- HSPB2 p.Asp94Asn Uncertain significance Single submitter
- HSPB2 p.Phe112Ile Uncertain significance Single submitter
- HSPB2 p.Pro21Leu Uncertain significance Single submitter
- HSPB2 p.Pro41Thr Uncertain significance Single submitter
- HSPB2 p.Ser81Arg Uncertain significance Single submitter
- HSPB2 p.Tyr16Asn Uncertain significance Single submitter
All HSPB2 variants
Benign/Likely benign 1
- p.Gly111Ser Multiple submitters
Likely benign 1
- p.Ala54Thr Single submitter
Uncertain significance 23
- p.Ala178Thr Single submitter ⚠
- p.Ala62Thr Single submitter ⚠
- p.Arg102Trp Single submitter ⚠
- p.Arg106His Single submitter ⚠
- p.Arg115Gln Single submitter ⚠
- p.Arg115Pro Single submitter ⚠
- p.Arg4Ser Single submitter ⚠
- p.Asp94Asn Single submitter ⚠
- p.Glu181Lys Single submitter ⚠
- p.His138fs Single submitter
- p.His152Arg Single submitter ⚠
- p.His8Arg Single submitter
- p.Phe112Ile Single submitter ⚠
- p.Pro104Ser Single submitter ⚠
- p.Pro124Thr Single submitter ⚠
- p.Pro21Leu Single submitter ⚠
- p.Pro41Thr Single submitter ⚠
- p.Ser22Arg Single submitter
- p.Ser81Arg Single submitter ⚠
- p.Tyr121His Single submitter ⚠
- p.Tyr16Asn Single submitter ⚠
- p.Val113Met Single submitter ⚠
- p.Val88Met Single submitter ⚠