HSPBP1 — 64 ClinVar variants
All ClinVar germline HSPBP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
2 Benign · 5 Likely benign · 57 Uncertain significance
Full HSPBP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HSPBP1 p.Ala114Val Uncertain significance Single submitter
- HSPBP1 p.Ala138Thr Uncertain significance Single submitter
- HSPBP1 p.Ala159Thr Uncertain significance Single submitter
- HSPBP1 p.Ala208Thr Uncertain significance Single submitter
- HSPBP1 p.Arg10Leu Uncertain significance Single submitter
- HSPBP1 p.Arg152Gln Uncertain significance Single submitter
- HSPBP1 p.Arg152Trp Uncertain significance Single submitter
- HSPBP1 p.Arg190Cys Uncertain significance Single submitter
- HSPBP1 p.Arg190His Uncertain significance Single submitter
- HSPBP1 p.Arg190Ser Uncertain significance Single submitter
- HSPBP1 p.Arg194Trp Uncertain significance Single submitter
- HSPBP1 p.Arg198Cys Uncertain significance Single submitter
- HSPBP1 p.Arg205Cys Uncertain significance Single submitter
- HSPBP1 p.Arg205His Uncertain significance Single submitter
- HSPBP1 p.Arg282Gln Uncertain significance Single submitter
- HSPBP1 p.Arg308His Uncertain significance Single submitter
- HSPBP1 p.Arg359Gln Uncertain significance Single submitter
- HSPBP1 p.Arg84Gln Uncertain significance Single submitter
- HSPBP1 p.Arg87Gln Uncertain significance Single submitter
- HSPBP1 p.Arg98Gln Uncertain significance Single submitter
- HSPBP1 p.Asn44Lys Uncertain significance Single submitter
- HSPBP1 p.Asp354Glu Uncertain significance Single submitter
- HSPBP1 p.Asp355Asn Uncertain significance Single submitter
- HSPBP1 p.Cys214Tyr Uncertain significance Single submitter
- HSPBP1 p.Cys325Phe Uncertain significance Single submitter
- HSPBP1 p.Gln275Glu Uncertain significance Single submitter
- HSPBP1 p.Glu110Val Uncertain significance Single submitter
- HSPBP1 p.Gly122Arg Uncertain significance Single submitter
- HSPBP1 p.Gly21Val Uncertain significance Single submitter
- HSPBP1 p.Gly29Ser Uncertain significance Single submitter
- HSPBP1 p.His331Arg Uncertain significance Single submitter
- HSPBP1 p.Leu215Val Uncertain significance Single submitter
- HSPBP1 p.Leu223Pro Uncertain significance Single submitter
- HSPBP1 p.Pro12Leu Uncertain significance Single submitter
- HSPBP1 p.Pro17Ala Uncertain significance Single submitter
- HSPBP1 p.Pro304Leu Uncertain significance Single submitter
- HSPBP1 p.Ser270Thr Uncertain significance Single submitter
- HSPBP1 p.Ser80Leu Uncertain significance Single submitter
- HSPBP1 p.Thr107Asn Uncertain significance Single submitter
- HSPBP1 p.Thr171Met Uncertain significance Single submitter
- HSPBP1 p.Val176Met Uncertain significance Single submitter
- HSPBP1 p.Val206Ile Uncertain significance Single submitter
- HSPBP1 p.Val243Leu Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- HSPBP1 p.Ala156Val Uncertain significance Single submitter
- HSPBP1 p.Ala211Ser Uncertain significance Single submitter
- HSPBP1 p.Ala251Thr Uncertain significance Single submitter
- HSPBP1 p.Arg322Cys Uncertain significance Single submitter
- HSPBP1 p.Arg87Pro Uncertain significance Single submitter
- HSPBP1 p.Glu112Lys Uncertain significance Single submitter
- HSPBP1 p.Gly170Ala Uncertain significance Single submitter
- HSPBP1 p.Gly25Trp Uncertain significance Single submitter
- HSPBP1 p.Leu227Phe Uncertain significance Single submitter
- HSPBP1 p.Phe83Ser Uncertain significance Single submitter
- HSPBP1 p.Pro313Leu Uncertain significance Single submitter
- HSPBP1 p.Val234Leu Uncertain significance Single submitter
- HSPBP1 p.Val300Leu Likely benign Single submitter
All HSPBP1 variants
Benign 2
- p.Asn44= Single submitter
- p.Gly28_Gly30dup Single submitter
Likely benign 5
Uncertain significance 57
- p.Ala114Val Single submitter ⚠
- p.Ala138Thr Single submitter ⚠
- p.Ala156Val Single submitter ⚠
- p.Ala159Thr Single submitter ⚠
- p.Ala208Thr Single submitter ⚠
- p.Ala211Ser Single submitter ⚠
- p.Ala251Thr Single submitter ⚠
- p.Arg10Leu Single submitter ⚠
- p.Arg152Gln Single submitter ⚠
- p.Arg152Trp Single submitter ⚠
- p.Arg190Cys Single submitter ⚠
- p.Arg190His Single submitter ⚠
- p.Arg190Ser Single submitter ⚠
- p.Arg194Trp Single submitter ⚠
- p.Arg198Cys Single submitter ⚠
- p.Arg205Cys Single submitter ⚠
- p.Arg205His Single submitter ⚠
- p.Arg282Gln Single submitter ⚠
- p.Arg308His Single submitter ⚠
- p.Arg322Cys Single submitter ⚠
- p.Arg324His Single submitter
- p.Arg359Gln Single submitter ⚠
- p.Arg84Gln Single submitter ⚠
- p.Arg87Gln Single submitter ⚠
- p.Arg87Pro Single submitter ⚠
- p.Arg98Gln Single submitter ⚠
- p.Asn44Lys Single submitter ⚠
- p.Asp354Glu Single submitter ⚠
- p.Asp355Asn Single submitter ⚠
- p.Cys214Tyr Single submitter ⚠
- p.Cys325Phe Single submitter ⚠
- p.Gln275Glu Single submitter ⚠
- p.Glu110Val Single submitter ⚠
- p.Glu112Lys Single submitter ⚠
- p.Gly122Arg Single submitter ⚠
- p.Gly170Ala Single submitter ⚠
- p.Gly21Val Single submitter ⚠
- p.Gly25Trp Single submitter ⚠
- p.Gly29Ser Single submitter ⚠
- p.His331Arg Single submitter ⚠
- p.Leu215Val Single submitter ⚠
- p.Leu223Pro Single submitter ⚠
- p.Leu227Phe Single submitter ⚠
- p.Leu45Phe Single submitter
- p.Phe83Ser Single submitter ⚠
- p.Pro12Leu Single submitter ⚠
- p.Pro17Ala Single submitter ⚠
- p.Pro304Leu Single submitter ⚠
- p.Pro313Leu Single submitter ⚠
- p.Ser270Thr Single submitter ⚠
- p.Ser80Leu Single submitter ⚠
- p.Thr107Asn Single submitter ⚠
- p.Thr171Met Single submitter ⚠
- p.Val176Met Single submitter ⚠
- p.Val206Ile Single submitter ⚠
- p.Val234Leu Single submitter ⚠
- p.Val243Leu Single submitter ⚠