HTR1B — 37 ClinVar variants
All ClinVar germline HTR1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
5 Likely benign · 32 Uncertain significance
Full HTR1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HTR1B p.Ala150Ser Uncertain significance Single submitter
- HTR1B p.Ala322Val Uncertain significance Single submitter
- HTR1B p.Ala9Val Uncertain significance Single submitter
- HTR1B p.Arg253Gln Uncertain significance Single submitter
- HTR1B p.Asn361Lys Uncertain significance Single submitter
- HTR1B p.Asn67Lys Uncertain significance Single submitter
- HTR1B p.Cys388Arg Uncertain significance Single submitter
- HTR1B p.Cys388Tyr Uncertain significance Single submitter
- HTR1B p.Gln7Pro Uncertain significance Single submitter
- HTR1B p.Glu156Asp Uncertain significance Single submitter
- HTR1B p.Gly358Arg Uncertain significance Single submitter
- HTR1B p.Ile100Val Uncertain significance Single submitter
- HTR1B p.Ile143Phe Uncertain significance Single submitter
- HTR1B p.Ile332Val Uncertain significance Single submitter
- HTR1B p.Ile350Val Uncertain significance Single submitter
- HTR1B p.Leu299Gln Uncertain significance Single submitter
- HTR1B p.Lys164Asn Uncertain significance Single submitter
- HTR1B p.Met108Leu Uncertain significance Single submitter
- HTR1B p.Pro244Leu Uncertain significance Single submitter
- HTR1B p.Pro244Thr Uncertain significance Single submitter
- HTR1B p.Pro29Ser Uncertain significance Single submitter
- HTR1B p.Ser269Phe Uncertain significance Single submitter
- HTR1B p.Thr112Asn Uncertain significance Single submitter
- HTR1B p.Thr134Ile Uncertain significance Single submitter
- HTR1B p.Tyr38Ser Uncertain significance Single submitter
- HTR1B p.Val173Ala Uncertain significance Single submitter
- HTR1B p.Val214Met Uncertain significance Single submitter
- HTR1B p.Val325Met Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All HTR1B variants
Likely benign 5
- p.Ala35= Single submitter
- p.Ala35Thr Single submitter
- p.Ile105Val Single submitter
- p.Ile225= Single submitter
- p.Met337Leu Single submitter
Uncertain significance 32
- p.Ala150Ser Single submitter ⚠
- p.Ala322Val Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg253Gln Single submitter ⚠
- p.Asn361Lys Single submitter ⚠
- p.Asn67Lys Single submitter ⚠
- p.Cys388Arg Single submitter ⚠
- p.Cys388Tyr Single submitter ⚠
- p.Gln7Pro Single submitter ⚠
- p.Glu156Asp Single submitter ⚠
- p.Gly358Arg Single submitter ⚠
- p.Ile100Val Single submitter ⚠
- p.Ile143Phe Single submitter ⚠
- p.Ile206Thr Single submitter
- p.Ile332Val Single submitter ⚠
- p.Ile350Val Single submitter ⚠
- p.Leu299Gln Single submitter ⚠
- p.Lys164Asn Single submitter ⚠
- p.Met108Leu Single submitter ⚠
- p.Phe346Leu Single submitter ⚠
- p.Pro244Leu Single submitter ⚠
- p.Pro244Thr Single submitter ⚠
- p.Pro29Ser Single submitter ⚠
- p.Ser127Leu Single submitter
- p.Ser269Phe Single submitter ⚠
- p.Ser45Cys Single submitter ⚠
- p.Thr112Asn Single submitter ⚠
- p.Thr134Ile Single submitter ⚠
- p.Tyr38Ser Single submitter ⚠
- p.Val173Ala Single submitter ⚠
- p.Val214Met Single submitter ⚠
- p.Val325Met Single submitter ⚠