HTR3A — 96 ClinVar variants

All ClinVar germline HTR3A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →

6 Benign · 6 Likely benign · 84 Uncertain significance

Full HTR3A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 78

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 57

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 21

The independent predictors disagree with each other — read with care.

All HTR3A variants

Benign 6

p.Ile261= Multiple submitters
p.Ser447= Multiple submitters
c.374+9C>T Single submitter
c.-7G>T Single submitter
p.Arg409Gln Single submitter
p.Gly271= Single submitter

Likely benign 6

c.374+10G>A Single submitter
p.Arg140Gln Single submitter
p.Arg219Trp Single submitter ⚠
p.Arg399= Single submitter
p.Leu343= Single submitter
p.Tyr136= Single submitter

Uncertain significance 84

p.Arg27Gln Multiple submitters ⚠
p.Ala230Gly Single submitter ⚠
p.Ala299Val Single submitter ⚠
p.Ala352Thr Single submitter ⚠
p.Ala368Pro Single submitter ⚠
p.Ala478Thr Single submitter ⚠
p.Ala69Asp Single submitter ⚠
p.Arg191His Single submitter ⚠
p.Arg239Cys Single submitter ⚠
p.Arg240Gln Single submitter ⚠
p.Arg24Met Single submitter ⚠
p.Arg344Cys Single submitter ⚠
p.Arg399Thr Single submitter ⚠
p.Arg432Trp Single submitter ⚠
p.Arg444Cys Single submitter ⚠
p.Arg46Gly Single submitter ⚠
p.Arg56Met Single submitter
p.Arg87Pro Single submitter ⚠
p.Asn147Lys Single submitter ⚠
p.Asn44Lys Single submitter ⚠
p.Asn72Lys Single submitter ⚠
p.Asp160Asn Single submitter ⚠
p.Asp393Asn Single submitter ⚠
p.Cys157Tyr Single submitter ⚠
p.Cys171Ser Single submitter ⚠
p.Cys416Tyr Single submitter ⚠
p.Gln142Lys Single submitter ⚠
p.Gln337Arg Single submitter ⚠
p.Glu124Lys Single submitter ⚠
p.Glu144Lys Single submitter ⚠
p.Glu208Asp Single submitter ⚠
p.Glu220Lys Single submitter ⚠
p.Glu272Lys Single submitter ⚠
p.Glu322Lys Single submitter ⚠
p.Glu395Lys Single submitter ⚠
p.Gly129Glu Single submitter ⚠
p.Gly213Glu Single submitter ⚠
p.Gly213Val Single submitter ⚠
p.Gly263Ser Single submitter ⚠
p.Gly271Ser Single submitter ⚠
p.Gly301Ser Single submitter ⚠
p.His384Tyr Single submitter ⚠
p.Ile187Phe Single submitter ⚠
p.Ile351Asn Single submitter ⚠
p.Leu173Arg Single submitter ⚠
p.Leu250Ile Single submitter ⚠
p.Leu304Phe Single submitter ⚠
p.Leu346Arg Single submitter ⚠
p.Leu453Val Single submitter ⚠
p.Lys130Met Single submitter ⚠
p.Met259Thr Single submitter ⚠
p.Met313Val Single submitter ⚠
p.Met381Thr Single submitter ⚠
p.Pro216Ser Single submitter ⚠
p.Pro242Ser Single submitter ⚠
p.Pro267Thr Single submitter ⚠
p.Pro296Leu Single submitter ⚠
p.Pro303Arg Single submitter ⚠
p.Pro405Ser Single submitter ⚠
p.Pro406Arg Single submitter ⚠
p.Ser226Arg Single submitter ⚠
p.Ser26Arg Single submitter ⚠
p.Ser370Pro Single submitter ⚠
p.Ser412Trp Single submitter ⚠
p.Thr112Met Single submitter ⚠
p.Thr298Ser Single submitter ⚠
p.Thr369Ile Single submitter ⚠
p.Thr59Ile Single submitter ⚠
p.Trp190Arg Single submitter
p.Trp342Cys Single submitter ⚠
p.Tyr217Cys Single submitter ⚠
p.Tyr217His Single submitter ⚠
p.Tyr228fs Single submitter
p.Tyr45Cys Single submitter ⚠
p.Val126Met Single submitter
p.Val128Ala Single submitter ⚠
p.Val137Leu Single submitter
p.Val258Phe Single submitter ⚠
p.Val339Met Single submitter
p.Val445Met Single submitter
p.Val448Met Single submitter ⚠
p.Val52Met Single submitter ⚠
p.Val61Ile Single submitter ⚠
p.Val65Ile Single submitter ⚠