HTR3B — 80 ClinVar variants
All ClinVar germline HTR3B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →
1 Conflicting · 2 Benign · 4 Likely benign · 73 Uncertain significance
Full HTR3B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 74
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HTR3B p.Ala11Thr Uncertain significance Single submitter
- HTR3B p.Ala56Val Uncertain significance Single submitter
- HTR3B p.Arg268Gly Uncertain significance Single submitter
- HTR3B p.Arg343Gly Uncertain significance Single submitter
- HTR3B p.Arg359Cys Uncertain significance Single submitter
- HTR3B p.Arg411Cys Uncertain significance Single submitter
- HTR3B p.Arg411His Uncertain significance Single submitter
- HTR3B p.Asn145Lys Uncertain significance Single submitter
- HTR3B p.Asn232Ser Uncertain significance Single submitter
- HTR3B p.Asp117Asn Uncertain significance Single submitter
- HTR3B p.Asp117His Uncertain significance Single submitter
- HTR3B p.Asp125Asn Uncertain significance Single submitter
- HTR3B p.Asp165Val Uncertain significance Single submitter
- HTR3B p.Asp23Asn Uncertain significance Single submitter
- HTR3B p.Asp257Tyr Uncertain significance Single submitter
- HTR3B p.Asp347Asn Uncertain significance Single submitter
- HTR3B p.Gln195His Uncertain significance Single submitter
- HTR3B p.Gln228Arg Uncertain significance Single submitter
- HTR3B p.Glu192Gln Uncertain significance Single submitter
- HTR3B p.Glu370Lys Uncertain significance Single submitter
- HTR3B p.Glu404Lys Uncertain significance Single submitter
- HTR3B p.Gly333Asp Uncertain significance Single submitter
- HTR3B p.Gly425Val Uncertain significance Single submitter
- HTR3B p.His238Leu Uncertain significance Single submitter
- HTR3B p.His66Tyr Uncertain significance Single submitter
- HTR3B p.Ile13Leu Uncertain significance Single submitter
- HTR3B p.Ile13Thr Uncertain significance Single submitter
- HTR3B p.Ile149Val Uncertain significance Single submitter
- HTR3B p.Ile229Val Uncertain significance Single submitter
- HTR3B p.Ile248Val Uncertain significance Single submitter
- HTR3B p.Ile426Val Uncertain significance Single submitter
- HTR3B p.Ile429Thr Uncertain significance Single submitter
- HTR3B p.Leu202Phe Uncertain significance Single submitter
- HTR3B p.Leu20Pro Uncertain significance Single submitter
- HTR3B p.Leu253Pro Uncertain significance Single submitter
- HTR3B p.Leu263Pro Uncertain significance Single submitter
- HTR3B p.Lys147Arg Uncertain significance Single submitter
- HTR3B p.Lys319Arg Uncertain significance Single submitter
- HTR3B p.Met288Val Uncertain significance Single submitter
- HTR3B p.Met423Thr Uncertain significance Single submitter
- HTR3B p.Phe306Val Uncertain significance Single submitter
- HTR3B p.Pro116Ser Uncertain significance Single submitter
- HTR3B p.Pro130Thr Uncertain significance Single submitter
- HTR3B p.Pro191Ala Uncertain significance Single submitter
- HTR3B p.Pro338Ala Uncertain significance Single submitter
- HTR3B p.Pro49Ser Uncertain significance Single submitter
- HTR3B p.Ser156Asn Uncertain significance Single submitter
- HTR3B p.Ser211Phe Uncertain significance Single submitter
- HTR3B p.Ser221Asn Uncertain significance Single submitter
- HTR3B p.Ser222Gly Uncertain significance Single submitter
- HTR3B p.Ser36Gly Uncertain significance Single submitter
- HTR3B p.Ser383Leu Uncertain significance Single submitter
- HTR3B p.Ser3Pro Uncertain significance Single submitter
- HTR3B p.Thr54Ala Uncertain significance Single submitter
- HTR3B p.Val244Met Uncertain significance Single submitter
- HTR3B p.Val65Ile Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- HTR3B p.Asp72Val Uncertain significance Single submitter
- HTR3B p.His196Pro Uncertain significance Single submitter
- HTR3B p.Ile118Thr Uncertain significance Single submitter
- HTR3B p.Ile271Ser Conflicting Single submitter
- HTR3B p.Leu313Ser Uncertain significance Single submitter
- HTR3B p.Met288Arg Uncertain significance Single submitter
- HTR3B p.Met310Val Uncertain significance Single submitter
- HTR3B p.Phe261Tyr Uncertain significance Single submitter
- HTR3B p.Phe273Leu Uncertain significance Single submitter
- HTR3B p.Pro109His Uncertain significance Single submitter
- HTR3B p.Pro239His Uncertain significance Single submitter
- HTR3B p.Pro293Leu Uncertain significance Single submitter
- HTR3B p.Ser139Leu Uncertain significance Single submitter
- HTR3B p.Trp405Cys Uncertain significance Single submitter
- HTR3B p.Trp405Leu Uncertain significance Single submitter
- HTR3B p.Tyr136Cys Uncertain significance Single submitter
- HTR3B p.Tyr160Cys Uncertain significance Single submitter
- HTR3B p.Val283Ala Uncertain significance Single submitter
All HTR3B variants
Conflicting classifications of pathogenicity 1
- p.Ile271Ser Single submitter ⚠
Benign 2
- c.369-3T>C Single submitter
- p.Glu354Lys Single submitter
Likely benign 4
- p.Leu323Val Multiple submitters
- p.Arg414Gln Single submitter
- p.Asn390Ser Single submitter
- p.Lys42Asn Single submitter
Uncertain significance 73
- p.Ala11Thr Single submitter ⚠
- p.Ala56Val Single submitter ⚠
- p.Arg268Gly Single submitter ⚠
- p.Arg343Gly Single submitter ⚠
- p.Arg359Cys Single submitter ⚠
- p.Arg411Cys Single submitter ⚠
- p.Arg411His Single submitter ⚠
- p.Asn145Lys Single submitter ⚠
- p.Asn232Ser Single submitter ⚠
- p.Asp117Asn Single submitter ⚠
- p.Asp117His Single submitter ⚠
- p.Asp125Asn Single submitter ⚠
- p.Asp165Val Single submitter ⚠
- p.Asp23Asn Single submitter ⚠
- p.Asp257Tyr Single submitter ⚠
- p.Asp347Asn Single submitter ⚠
- p.Asp72Val Single submitter ⚠
- p.Gln195His Single submitter ⚠
- p.Gln228Arg Single submitter ⚠
- p.Glu192Gln Single submitter ⚠
- p.Glu370Lys Single submitter ⚠
- p.Glu404Lys Single submitter ⚠
- p.Gly333Asp Single submitter ⚠
- p.Gly425Val Single submitter ⚠
- p.His196Pro Single submitter ⚠
- p.His238Leu Single submitter ⚠
- p.His66Tyr Single submitter ⚠
- p.Ile118Thr Single submitter ⚠
- p.Ile13Leu Single submitter ⚠
- p.Ile13Thr Single submitter ⚠
- p.Ile149Val Single submitter ⚠
- p.Ile229Val Single submitter ⚠
- p.Ile248Val Single submitter ⚠
- p.Ile426Val Single submitter ⚠
- p.Ile429Thr Single submitter ⚠
- p.Leu202Phe Single submitter ⚠
- p.Leu20Pro Single submitter ⚠
- p.Leu253Pro Single submitter ⚠
- p.Leu263Pro Single submitter ⚠
- p.Leu313Ser Single submitter ⚠
- p.Lys147Arg Single submitter ⚠
- p.Lys319Arg Single submitter ⚠
- p.Met288Arg Single submitter ⚠
- p.Met288Val Single submitter ⚠
- p.Met310Val Single submitter ⚠
- p.Met423Thr Single submitter ⚠
- p.Phe261Tyr Single submitter ⚠
- p.Phe273Leu Single submitter ⚠
- p.Phe306Val Single submitter ⚠
- p.Pro109His Single submitter ⚠
- p.Pro116Ser Single submitter ⚠
- p.Pro130Thr Single submitter ⚠
- p.Pro191Ala Single submitter ⚠
- p.Pro239His Single submitter ⚠
- p.Pro293Leu Single submitter ⚠
- p.Pro338Ala Single submitter ⚠
- p.Pro49Ser Single submitter ⚠
- p.Ser139Leu Single submitter ⚠
- p.Ser156Asn Single submitter ⚠
- p.Ser211Phe Single submitter ⚠
- p.Ser221Asn Single submitter ⚠
- p.Ser222Gly Single submitter ⚠
- p.Ser36Gly Single submitter ⚠
- p.Ser383Leu Single submitter ⚠
- p.Ser3Pro Single submitter ⚠
- p.Thr54Ala Single submitter ⚠
- p.Trp405Cys Single submitter ⚠
- p.Trp405Leu Single submitter ⚠
- p.Tyr136Cys Single submitter ⚠
- p.Tyr160Cys Single submitter ⚠
- p.Val244Met Single submitter ⚠
- p.Val283Ala Single submitter ⚠
- p.Val65Ile Single submitter ⚠