HTR3C — 72 ClinVar variants
All ClinVar germline HTR3C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
5 Benign · 11 Likely benign · 56 Uncertain significance
Full HTR3C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HTR3C p.Ala242Val Uncertain significance Single submitter
- HTR3C p.Ala313Thr Uncertain significance Single submitter
- HTR3C p.Ala364Val Uncertain significance Single submitter
- HTR3C p.Arg345Ser Uncertain significance Single submitter
- HTR3C p.Arg428Cys Uncertain significance Single submitter
- HTR3C p.Arg428His Uncertain significance Single submitter
- HTR3C p.Asn111Asp Uncertain significance Single submitter
- HTR3C p.Asp132Val Uncertain significance Single submitter
- HTR3C p.Asp265Gly Uncertain significance Single submitter
- HTR3C p.Asp26Asn Uncertain significance Single submitter
- HTR3C p.Asp26Gly Uncertain significance Single submitter
- HTR3C p.Asp41Glu Uncertain significance Single submitter
- HTR3C p.Asp423Gly Uncertain significance Single submitter
- HTR3C p.Cys360Tyr Uncertain significance Single submitter
- HTR3C p.Gln37Lys Uncertain significance Single submitter
- HTR3C p.Gln9His Uncertain significance Single submitter
- HTR3C p.Glu384Asp Uncertain significance Single submitter
- HTR3C p.Glu413Asp Uncertain significance Single submitter
- HTR3C p.Ile243Val Uncertain significance Single submitter
- HTR3C p.Ile251Leu Uncertain significance Single submitter
- HTR3C p.Ile329Val Uncertain significance Single submitter
- HTR3C p.Leu267Val Uncertain significance Single submitter
- HTR3C p.Leu316Arg Uncertain significance Single submitter
- HTR3C p.Leu323Gln Uncertain significance Single submitter
- HTR3C p.Lys151Arg Uncertain significance Single submitter
- HTR3C p.Lys391Asn Uncertain significance Single submitter
- HTR3C p.Met156Ile Uncertain significance Single submitter
- HTR3C p.Phe281Cys Uncertain significance Single submitter
- HTR3C p.Ser146Asn Uncertain significance Single submitter
- HTR3C p.Ser181Gly Uncertain significance Single submitter
- HTR3C p.Ser248Gly Uncertain significance Single submitter
- HTR3C p.Ser437Ala Uncertain significance Single submitter
- HTR3C p.Thr186Ala Uncertain significance Single submitter
- HTR3C p.Thr398Ile Uncertain significance Single submitter
- HTR3C p.Thr424Ile Uncertain significance Single submitter
- HTR3C p.Thr86Ile Uncertain significance Single submitter
- HTR3C p.Trp215Arg Uncertain significance Single submitter
- HTR3C p.Trp406Arg Uncertain significance Single submitter
- HTR3C p.Trp415Arg Uncertain significance Single submitter
- HTR3C p.Val133Ala Uncertain significance Single submitter
- HTR3C p.Val321Phe Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- HTR3C p.Arg206Cys Uncertain significance Single submitter
- HTR3C p.Arg245Cys Uncertain significance Single submitter
- HTR3C p.Arg245His Likely benign Single submitter
- HTR3C p.Arg278His Likely benign Single submitter
- HTR3C p.Gly39Ala Uncertain significance Single submitter
- HTR3C p.Ile144Phe Uncertain significance Single submitter
- HTR3C p.Ile201Thr Uncertain significance Single submitter
- HTR3C p.Leu184Pro Uncertain significance Single submitter
- HTR3C p.Leu351Met Uncertain significance Single submitter
- HTR3C p.Phe183Leu Uncertain significance Single submitter
- HTR3C p.Thr136Met Uncertain significance Single submitter
- HTR3C p.Thr16Asn Uncertain significance Single submitter
- HTR3C p.Tyr168Cys Uncertain significance Single submitter
- HTR3C p.Tyr250Cys Uncertain significance Single submitter
All HTR3C variants
Benign 5
- p.Asp26= Multiple submitters
- p.Ser160= Multiple submitters
- p.Val441Ile Multiple submitters
- p.Gln366fs Single submitter
- p.Thr159Asn Single submitter
Likely benign 11
- p.Arg149Gln Single submitter
- p.Arg206His Single submitter
- p.Arg245His Single submitter ⚠
- p.Arg278His Single submitter ⚠
- p.Arg65His Single submitter
- p.Glu147Gly Single submitter
- p.Leu307Phe Single submitter
- p.Ser275= Single submitter
- p.Tyr331His Single submitter
- p.Val327Ile Single submitter
- p.Val335Leu Single submitter
Uncertain significance 56
- p.Ala242Val Single submitter ⚠
- p.Ala313Thr Single submitter ⚠
- p.Ala364Val Single submitter ⚠
- p.Arg206Cys Single submitter ⚠
- p.Arg245Cys Single submitter ⚠
- p.Arg345Ser Single submitter ⚠
- p.Arg428Cys Single submitter ⚠
- p.Arg428His Single submitter ⚠
- p.Asn111Asp Single submitter ⚠
- p.Asp132Val Single submitter ⚠
- p.Asp265Gly Single submitter ⚠
- p.Asp26Asn Single submitter ⚠
- p.Asp26Gly Single submitter ⚠
- p.Asp41Glu Single submitter ⚠
- p.Asp423Gly Single submitter ⚠
- p.Cys360Tyr Single submitter ⚠
- p.Gln37Lys Single submitter ⚠
- p.Gln9His Single submitter ⚠
- p.Glu325Gly Single submitter
- p.Glu384Asp Single submitter ⚠
- p.Glu413Asp Single submitter ⚠
- p.Gly39Ala Single submitter ⚠
- p.Ile144Phe Single submitter ⚠
- p.Ile201Thr Single submitter ⚠
- p.Ile243Val Single submitter ⚠
- p.Ile251Leu Single submitter ⚠
- p.Ile329Val Single submitter ⚠
- p.Leu184Pro Single submitter ⚠
- p.Leu191Pro Single submitter
- p.Leu267Val Single submitter ⚠
- p.Leu316Arg Single submitter ⚠
- p.Leu318Gln Single submitter
- p.Leu323Gln Single submitter ⚠
- p.Leu351Met Single submitter ⚠
- p.Lys151Arg Single submitter ⚠
- p.Lys391Asn Single submitter ⚠
- p.Met156Ile Single submitter ⚠
- p.Phe183Leu Single submitter ⚠
- p.Phe281Cys Single submitter ⚠
- p.Ser146Asn Single submitter ⚠
- p.Ser181Gly Single submitter ⚠
- p.Ser248Gly Single submitter ⚠
- p.Ser437Ala Single submitter ⚠
- p.Thr136Met Single submitter ⚠
- p.Thr16Asn Single submitter ⚠
- p.Thr186Ala Single submitter ⚠
- p.Thr398Ile Single submitter ⚠
- p.Thr424Ile Single submitter ⚠
- p.Thr86Ile Single submitter ⚠
- p.Trp215Arg Single submitter ⚠
- p.Trp406Arg Single submitter ⚠
- p.Trp415Arg Single submitter ⚠
- p.Tyr168Cys Single submitter ⚠
- p.Tyr250Cys Single submitter ⚠
- p.Val133Ala Single submitter ⚠
- p.Val321Phe Single submitter ⚠