HTR3D — 91 ClinVar variants
All ClinVar germline HTR3D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →
16 Likely benign · 75 Uncertain significance
Full HTR3D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 70
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 68
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HTR3D c.112-12C>A Uncertain significance Single submitter
- HTR3D c.112-17A>G Uncertain significance Single submitter
- HTR3D c.112-24C>G Uncertain significance Single submitter
- HTR3D c.66+1034A>G Uncertain significance Single submitter
- HTR3D c.66+1048C>G Uncertain significance Single submitter
- HTR3D c.66+1052C>A Uncertain significance Single submitter
- HTR3D c.66+1052C>G Uncertain significance Single submitter
- HTR3D c.66+1063C>G Uncertain significance Single submitter
- HTR3D c.66+1121G>C Uncertain significance Single submitter
- HTR3D c.66+1126G>C Uncertain significance Single submitter
- HTR3D c.66+1160C>T Uncertain significance Single submitter
- HTR3D c.66+1216G>A Uncertain significance Single submitter
- HTR3D c.67-4C>G Uncertain significance Single submitter
- HTR3D c.67-4C>T Uncertain significance Single submitter
- HTR3D c.770-12C>A Uncertain significance Single submitter
- HTR3D c.770-19C>A Uncertain significance Single submitter
- HTR3D p.Ala174Thr Uncertain significance Single submitter
- HTR3D p.Ala312Val Uncertain significance Single submitter
- HTR3D p.Ala357Thr Uncertain significance Single submitter
- HTR3D p.Ala83Thr Uncertain significance Single submitter
- HTR3D p.Ala97Glu Uncertain significance Single submitter
- HTR3D p.Arg124Gln Uncertain significance Single submitter
- HTR3D p.Arg144Thr Uncertain significance Single submitter
- HTR3D p.Arg155Thr Uncertain significance Single submitter
- HTR3D p.Arg307Ser Uncertain significance Single submitter
- HTR3D p.Arg385Cys Uncertain significance Single submitter
- HTR3D p.Cys43Tyr Uncertain significance Single submitter
- HTR3D p.Gln168Arg Uncertain significance Single submitter
- HTR3D p.Gln69His Uncertain significance Single submitter
- HTR3D p.Gln69Lys Uncertain significance Single submitter
- HTR3D p.Glu332Asp Uncertain significance Single submitter
- HTR3D p.Glu362Lys Uncertain significance Single submitter
- HTR3D p.Glu64Lys Uncertain significance Single submitter
- HTR3D p.Gly222Asp Uncertain significance Single submitter
- HTR3D p.Gly342Ser Uncertain significance Single submitter
- HTR3D p.Gly44Glu Uncertain significance Single submitter
- HTR3D p.Gly73Asp Uncertain significance Single submitter
- HTR3D p.His136Pro Uncertain significance Single submitter
- HTR3D p.His242Arg Uncertain significance Single submitter
- HTR3D p.His242Gln Uncertain significance Single submitter
- HTR3D p.His301Tyr Uncertain significance Single submitter
- HTR3D p.Ile63Val Uncertain significance Single submitter
- HTR3D p.Ile88Arg Uncertain significance Single submitter
- HTR3D p.Leu291Val Uncertain significance Single submitter
- HTR3D p.Leu348Pro Uncertain significance Single submitter
- HTR3D p.Lys315Asn Uncertain significance Single submitter
- HTR3D p.Met229Leu Uncertain significance Single submitter
- HTR3D p.Met340Thr Uncertain significance Single submitter
- HTR3D p.Met379Thr Uncertain significance Single submitter
- HTR3D p.Met51Val Uncertain significance Single submitter
- HTR3D p.Pro183Arg Uncertain significance Single submitter
- HTR3D p.Pro310Ser Uncertain significance Single submitter
- HTR3D p.Pro313Ser Uncertain significance Single submitter
- HTR3D p.Pro333Leu Uncertain significance Single submitter
- HTR3D p.Pro333Ser Uncertain significance Single submitter
- HTR3D p.Ser104Phe Uncertain significance Single submitter
- HTR3D p.Ser182Asn Uncertain significance Single submitter
- HTR3D p.Ser270Arg Uncertain significance Single submitter
- HTR3D p.Ser49Pro Uncertain significance Single submitter
- HTR3D p.Ser96Tyr Uncertain significance Single submitter
- HTR3D p.Thr143Ser Uncertain significance Single submitter
- HTR3D p.Thr303Pro Uncertain significance Single submitter
- HTR3D p.Trp126Arg Uncertain significance Single submitter
- HTR3D p.Val173Leu Uncertain significance Single submitter
- HTR3D p.Val185Met Uncertain significance Single submitter
- HTR3D p.Val225Ile Uncertain significance Single submitter
- HTR3D p.Val283Met Uncertain significance Single submitter
- HTR3D p.Val67Glu Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All HTR3D variants
Likely benign 16
- c.112-1G>A Single submitter
- c.112-27C>T Single submitter
- p.Ala337Val Single submitter
- p.Ala378Val Single submitter
- p.Ala381Thr Single submitter
- p.Arg177Cys Single submitter
- p.Arg359Trp Single submitter
- p.Gln27= Single submitter
- p.Gly304Ser Single submitter
- p.Gly50Ser Single submitter
- p.Lys47Arg Single submitter
- p.Lys9Glu Single submitter
- p.Met107Thr Single submitter
- p.Pro320Leu Single submitter
- p.Val159Met Single submitter
- p.Val61Ile Single submitter
Uncertain significance 75
- c.112-12C>A Single submitter ⚠
- c.112-17A>G Single submitter ⚠
- c.112-24C>G Single submitter ⚠
- c.66+1034A>G Single submitter ⚠
- c.66+1048C>G Single submitter ⚠
- c.66+1052C>A Single submitter ⚠
- c.66+1052C>G Single submitter ⚠
- c.66+1063C>G Single submitter ⚠
- c.66+1121G>C Single submitter ⚠
- c.66+1126G>C Single submitter ⚠
- c.66+1160C>T Single submitter ⚠
- c.66+1216G>A Single submitter ⚠
- c.67-4C>G Single submitter ⚠
- c.67-4C>T Single submitter ⚠
- c.770-12C>A Single submitter ⚠
- c.770-19C>A Single submitter ⚠
- p.Ala174Thr Single submitter ⚠
- p.Ala312Val Single submitter ⚠
- p.Ala357Thr Single submitter ⚠
- p.Ala83Thr Single submitter ⚠
- p.Ala97Glu Single submitter ⚠
- p.Arg124Gln Single submitter ⚠
- p.Arg144Thr Single submitter ⚠
- p.Arg155Thr Single submitter ⚠
- p.Arg307Ser Single submitter ⚠
- p.Arg385Cys Single submitter ⚠
- p.Cys43Tyr Single submitter ⚠
- p.Gln168Arg Single submitter ⚠
- p.Gln69His Single submitter ⚠
- p.Gln69Lys Single submitter ⚠
- p.Glu332Asp Single submitter ⚠
- p.Glu362Lys Single submitter ⚠
- p.Glu64Lys Single submitter ⚠
- p.Gly222Asp Single submitter ⚠
- p.Gly342Ser Single submitter ⚠
- p.Gly44Glu Single submitter ⚠
- p.Gly4Val Single submitter
- p.Gly73Asp Single submitter ⚠
- p.His136Pro Single submitter ⚠
- p.His242Arg Single submitter ⚠
- p.His242Gln Single submitter ⚠
- p.His301Tyr Single submitter ⚠
- p.His7Tyr Single submitter
- p.Ile16Asn Single submitter
- p.Ile63Val Single submitter ⚠
- p.Ile88Arg Single submitter ⚠
- p.Leu291Val Single submitter ⚠
- p.Leu348Pro Single submitter ⚠
- p.Lys315Asn Single submitter ⚠
- p.Met229Leu Single submitter ⚠
- p.Met340Thr Single submitter ⚠
- p.Met379Thr Single submitter ⚠
- p.Met51Val Single submitter ⚠
- p.Phe11Leu Single submitter
- p.Pro183Arg Single submitter ⚠
- p.Pro310Ser Single submitter ⚠
- p.Pro313Ser Single submitter ⚠
- p.Pro333Leu Single submitter ⚠
- p.Pro333Ser Single submitter ⚠
- p.Ser104Phe Single submitter ⚠
- p.Ser182Asn Single submitter ⚠
- p.Ser270Arg Single submitter ⚠
- p.Ser49Pro Single submitter ⚠
- p.Ser96Tyr Single submitter ⚠
- p.Thr143Ser Single submitter ⚠
- p.Thr303Pro Single submitter ⚠
- p.Trp126Arg Single submitter ⚠
- p.Trp402Arg Single submitter ⚠
- p.Tyr387His Single submitter
- p.Val173Leu Single submitter ⚠
- p.Val185Met Single submitter ⚠
- p.Val225Ile Single submitter ⚠
- p.Val283Met Single submitter ⚠
- p.Val398Asp Single submitter ⚠
- p.Val67Glu Single submitter ⚠