HTR3E — 81 ClinVar variants
All ClinVar germline HTR3E variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
2 Benign · 14 Likely benign · 65 Uncertain significance
Full HTR3E gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HTR3E p.Ala116Val Uncertain significance Single submitter
- HTR3E p.Ala313Ser Uncertain significance Single submitter
- HTR3E p.Ala336Thr Uncertain significance Single submitter
- HTR3E p.Ala415Ser Uncertain significance Single submitter
- HTR3E p.Ala430Val Uncertain significance Single submitter
- HTR3E p.Arg345Trp Uncertain significance Single submitter
- HTR3E p.Arg437Cys Uncertain significance Single submitter
- HTR3E p.Arg437His Uncertain significance Single submitter
- HTR3E p.Arg55Leu Uncertain significance Single submitter
- HTR3E p.Asp265Gly Uncertain significance Single submitter
- HTR3E p.Gln37Arg Uncertain significance Single submitter
- HTR3E p.Glu384Gly Uncertain significance Single submitter
- HTR3E p.Glu405Ala Uncertain significance Single submitter
- HTR3E p.Gly139Ser Uncertain significance Single submitter
- HTR3E p.Gly230Glu Uncertain significance Single submitter
- HTR3E p.Gly371Asp Uncertain significance Single submitter
- HTR3E p.His419Asn Uncertain significance Single submitter
- HTR3E p.Ile243Met Uncertain significance Single submitter
- HTR3E p.Ile60Val Uncertain significance Single submitter
- HTR3E p.Leu120Val Uncertain significance Single submitter
- HTR3E p.Leu191Phe Uncertain significance Single submitter
- HTR3E p.Leu191Ser Uncertain significance Single submitter
- HTR3E p.Leu249Phe Uncertain significance Single submitter
- HTR3E p.Leu352Phe Uncertain significance Single submitter
- HTR3E p.Leu374Val Uncertain significance Single submitter
- HTR3E p.Lys135Asn Uncertain significance Single submitter
- HTR3E p.Met194Ile Uncertain significance Single submitter
- HTR3E p.Met431Val Uncertain significance Single submitter
- HTR3E p.Met443Thr Uncertain significance Single submitter
- HTR3E p.Phe281Leu Uncertain significance Single submitter
- HTR3E p.Pro123Gln Uncertain significance Single submitter
- HTR3E p.Pro357Leu Uncertain significance Single submitter
- HTR3E p.Pro365Leu Uncertain significance Single submitter
- HTR3E p.Pro372Gln Uncertain significance Single submitter
- HTR3E p.Ser114Asn Uncertain significance Single submitter
- HTR3E p.Thr305Asn Uncertain significance Single submitter
- HTR3E p.Thr326Ile Uncertain significance Single submitter
- HTR3E p.Thr407Arg Uncertain significance Single submitter
- HTR3E p.Thr64Ile Uncertain significance Single submitter
- HTR3E p.Trp102Arg Uncertain significance Single submitter
- HTR3E p.Trp406Arg Uncertain significance Single submitter
- HTR3E p.Val158Ala Uncertain significance Single submitter
- HTR3E p.Val273Leu Uncertain significance Single submitter
- HTR3E p.Val320Met Uncertain significance Single submitter
- HTR3E p.Val450Ile Uncertain significance Single submitter
- HTR3E p.Val62Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- HTR3E p.Asp134Gly Uncertain significance Single submitter
- HTR3E p.Asp188Tyr Uncertain significance Single submitter
- HTR3E p.Ile308Thr Uncertain significance Single submitter
- HTR3E p.Ile329Phe Uncertain significance Single submitter
- HTR3E p.Pro56Leu Uncertain significance Single submitter
- HTR3E p.Thr111Met Uncertain significance Single submitter
- HTR3E p.Thr326Asn Uncertain significance Single submitter
- HTR3E p.Thr338Pro Uncertain significance Single submitter
- HTR3E p.Tyr250Cys Uncertain significance Single submitter
- HTR3E p.Val48Gly Uncertain significance Single submitter
All HTR3E variants
Benign 2
- p.Ala71Thr Multiple submitters
- p.Leu425Val Multiple submitters
Likely benign 14
- p.Ala204Thr Single submitter
- p.Ala396= Single submitter
- p.Ala430= Single submitter
- p.Ala44Val Single submitter
- p.Arg206Gln Single submitter
- p.Gln65Arg Single submitter
- p.Glu368Gly Single submitter
- p.Met115Val Single submitter
- p.Met392Val Single submitter
- p.Met434Leu Single submitter
- p.Ser101Arg Single submitter
- p.Ser420Leu Single submitter
- p.Thr284Met Single submitter
- p.Val144Ile Single submitter
Uncertain significance 65
- c.68-100A>G Single submitter
- c.68-15C>G Single submitter
- c.68-84C>T Single submitter
- p.Ala116Val Single submitter ⚠
- p.Ala313Ser Single submitter ⚠
- p.Ala336Thr Single submitter ⚠
- p.Ala415Ser Single submitter ⚠
- p.Ala430Val Single submitter ⚠
- p.Arg345Trp Single submitter ⚠
- p.Arg437Cys Single submitter ⚠
- p.Arg437His Single submitter ⚠
- p.Arg55Leu Single submitter ⚠
- p.Asn253Lys Single submitter
- p.Asp134Gly Single submitter ⚠
- p.Asp188Tyr Single submitter ⚠
- p.Asp265Gly Single submitter ⚠
- p.Gln37Arg Single submitter ⚠
- p.Glu384Gly Single submitter ⚠
- p.Glu405Ala Single submitter ⚠
- p.Gly139Ser Single submitter ⚠
- p.Gly230Glu Single submitter ⚠
- p.Gly371Asp Single submitter ⚠
- p.His419Asn Single submitter ⚠
- p.Ile243Met Single submitter ⚠
- p.Ile308Thr Single submitter ⚠
- p.Ile329Phe Single submitter ⚠
- p.Ile60Val Single submitter ⚠
- p.Leu120Val Single submitter ⚠
- p.Leu191Phe Single submitter ⚠
- p.Leu191Ser Single submitter ⚠
- p.Leu249Phe Single submitter ⚠
- p.Leu314Gln Single submitter
- p.Leu352Phe Single submitter ⚠
- p.Leu374Val Single submitter ⚠
- p.Lys135Asn Single submitter ⚠
- p.Met190Thr Single submitter
- p.Met194Ile Single submitter ⚠
- p.Met431Val Single submitter ⚠
- p.Met443Thr Single submitter ⚠
- p.Met72Lys Single submitter
- p.Met72Thr Single submitter
- p.Phe281Leu Single submitter ⚠
- p.Pro123Gln Single submitter ⚠
- p.Pro357Leu Single submitter ⚠
- p.Pro365Leu Single submitter ⚠
- p.Pro372Gln Single submitter ⚠
- p.Pro56Leu Single submitter ⚠
- p.Ser114Asn Single submitter ⚠
- p.Thr111Met Single submitter ⚠
- p.Thr305Asn Single submitter ⚠
- p.Thr326Asn Single submitter ⚠
- p.Thr326Ile Single submitter ⚠
- p.Thr338Pro Single submitter ⚠
- p.Thr407Arg Single submitter ⚠
- p.Thr64Ile Single submitter ⚠
- p.Trp102Arg Single submitter ⚠
- p.Trp406Arg Single submitter ⚠
- p.Tyr250Cys Single submitter ⚠
- p.Tyr439Ser Single submitter
- p.Val158Ala Single submitter ⚠
- p.Val273Leu Single submitter ⚠
- p.Val320Met Single submitter ⚠
- p.Val450Ile Single submitter ⚠
- p.Val48Gly Single submitter ⚠
- p.Val62Leu Single submitter ⚠