HTR5A — 61 ClinVar variants
All ClinVar germline HTR5A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
5 Benign · 56 Uncertain significance
Full HTR5A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HTR5A p.Ala170Ser Uncertain significance Single submitter
- HTR5A p.Ala264Ser Uncertain significance Single submitter
- HTR5A p.Ala348Pro Uncertain significance Single submitter
- HTR5A p.Ala80Val Uncertain significance Single submitter
- HTR5A p.Ala90Thr Uncertain significance Single submitter
- HTR5A p.Arg262Cys Uncertain significance Single submitter
- HTR5A p.Arg282Gln Uncertain significance Single submitter
- HTR5A p.Arg30Cys Uncertain significance Single submitter
- HTR5A p.Arg30Ser Uncertain significance Single submitter
- HTR5A p.Asn342Lys Uncertain significance Single submitter
- HTR5A p.Gln254Lys Uncertain significance Single submitter
- HTR5A p.Gln356Arg Uncertain significance Single submitter
- HTR5A p.Glu244Gln Uncertain significance Single submitter
- HTR5A p.Glu244Lys Uncertain significance Single submitter
- HTR5A p.Glu277Asp Uncertain significance Single submitter
- HTR5A p.Glu277Lys Uncertain significance Single submitter
- HTR5A p.Gly110Arg Uncertain significance Single submitter
- HTR5A p.Gly25Asp Uncertain significance Single submitter
- HTR5A p.Gly25Ser Uncertain significance Single submitter
- HTR5A p.Ile162Val Uncertain significance Single submitter
- HTR5A p.Ile299Thr Uncertain significance Single submitter
- HTR5A p.Leu151Phe Uncertain significance Single submitter
- HTR5A p.Leu310Phe Uncertain significance Single submitter
- HTR5A p.Lys222Asn Uncertain significance Single submitter
- HTR5A p.Lys228Asn Uncertain significance Single submitter
- HTR5A p.Pro15Arg Uncertain significance Single submitter
- HTR5A p.Pro335Ser Uncertain significance Single submitter
- HTR5A p.Ser23Thr Uncertain significance Single submitter
- HTR5A p.Thr133Met Uncertain significance Single submitter
- HTR5A p.Thr274Arg Uncertain significance Single submitter
- HTR5A p.Thr274Lys Uncertain significance Single submitter
- HTR5A p.Thr304Ala Uncertain significance Single submitter
- HTR5A p.Thr64Ala Uncertain significance Single submitter
- HTR5A p.Trp181Cys Uncertain significance Single submitter
- HTR5A p.Trp221Leu Uncertain significance Single submitter
- HTR5A p.Trp325Arg Uncertain significance Single submitter
- HTR5A p.Tyr224His Uncertain significance Single submitter
- HTR5A p.Val246Met Uncertain significance Single submitter
- HTR5A p.Val295Leu Uncertain significance Single submitter
-
HTR5A p.Asp27His
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 14
The independent predictors disagree with each other — read with care.
- HTR5A p.Ala80Ser Uncertain significance Single submitter
- HTR5A p.Arg282Leu Uncertain significance Single submitter
- HTR5A p.Arg69Gly Uncertain significance Single submitter
- HTR5A p.Glu305Lys Uncertain significance Single submitter
- HTR5A p.Leu213Ile Uncertain significance Single submitter
- HTR5A p.Leu217Phe Uncertain significance Single submitter
- HTR5A p.Lys350Glu Uncertain significance Single submitter
- HTR5A p.Phe332Leu Uncertain significance Single submitter
- HTR5A p.Pro309Ser Uncertain significance Single submitter
- HTR5A p.Ser37Leu Uncertain significance Single submitter
- HTR5A p.Thr150Ala Uncertain significance Single submitter
- HTR5A p.Thr339Arg Uncertain significance Single submitter
- HTR5A p.Val41Met Uncertain significance Single submitter
- HTR5A p.Val61Leu Uncertain significance Single submitter
All HTR5A variants
Benign 5
Uncertain significance 56
- p.Ala170Ser Single submitter ⚠
- p.Ala264Ser Single submitter ⚠
- p.Ala348Pro Single submitter ⚠
- p.Ala80Ser Single submitter ⚠
- p.Ala80Val Single submitter ⚠
- p.Ala90Thr Single submitter ⚠
- p.Arg154His Single submitter
- p.Arg262Cys Single submitter ⚠
- p.Arg282Gln Single submitter ⚠
- p.Arg282Leu Single submitter ⚠
- p.Arg30Cys Single submitter ⚠
- p.Arg30Ser Single submitter ⚠
- p.Arg69Gly Single submitter ⚠
- p.Asn342Lys Single submitter ⚠
- p.Gln254Lys Single submitter ⚠
- p.Gln356Arg Single submitter ⚠
- p.Glu244Gln Single submitter ⚠
- p.Glu244Lys Single submitter ⚠
- p.Glu277Asp Single submitter ⚠
- p.Glu277Lys Single submitter ⚠
- p.Glu305Lys Single submitter ⚠
- p.Gly110Arg Single submitter ⚠
- p.Gly25Asp Single submitter ⚠
- p.Gly25Ser Single submitter ⚠
- p.Ile162Val Single submitter ⚠
- p.Ile299Thr Single submitter ⚠
- p.Leu151Phe Single submitter ⚠
- p.Leu213Ile Single submitter ⚠
- p.Leu217Phe Single submitter ⚠
- p.Leu310Phe Single submitter ⚠
- p.Lys222Asn Single submitter ⚠
- p.Lys228Asn Single submitter ⚠
- p.Lys350Glu Single submitter ⚠
- p.Phe332Leu Single submitter ⚠
- p.Pro15Arg Single submitter ⚠
- p.Pro309Ser Single submitter ⚠
- p.Pro335Ser Single submitter ⚠
- p.Ser23Thr Single submitter ⚠
- p.Ser37Leu Single submitter ⚠
- p.Thr133Met Single submitter ⚠
- p.Thr150Ala Single submitter ⚠
- p.Thr274Arg Single submitter ⚠
- p.Thr274Lys Single submitter ⚠
- p.Thr304Ala Single submitter ⚠
- p.Thr339Arg Single submitter ⚠
- p.Thr64Ala Single submitter ⚠
- p.Trp181Cys Single submitter ⚠
- p.Trp221Leu Single submitter ⚠
- p.Trp325Arg Single submitter ⚠
- p.Tyr224His Single submitter ⚠
- p.Val246Met Single submitter ⚠
- p.Val293Met Single submitter
- p.Val295Leu Single submitter ⚠
- p.Val41Met Single submitter ⚠
- p.Val61Leu Single submitter ⚠
- p.Asp27His No assertion criteria prostate cancer ⚠