HTR6 — 86 ClinVar variants
All ClinVar germline HTR6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
6 Benign · 8 Likely benign · 72 Uncertain significance
Full HTR6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HTR6 p.Ala112Thr Uncertain significance Single submitter
- HTR6 p.Ala415Ser Uncertain significance Single submitter
- HTR6 p.Ala43Val Uncertain significance Single submitter
- HTR6 p.Ala87Val Uncertain significance Single submitter
- HTR6 p.Ala95Val Uncertain significance Single submitter
- HTR6 p.Arg181Gly Uncertain significance Single submitter
- HTR6 p.Arg244His Uncertain significance Single submitter
- HTR6 p.Arg254Cys Uncertain significance Single submitter
- HTR6 p.Arg261Thr Uncertain significance Single submitter
- HTR6 p.Arg339Cys Uncertain significance Single submitter
- HTR6 p.Arg342Gln Uncertain significance Single submitter
- HTR6 p.Arg342Leu Uncertain significance Single submitter
- HTR6 p.Arg354Cys Uncertain significance Single submitter
- HTR6 p.Arg354His Uncertain significance Single submitter
- HTR6 p.Arg393Leu Uncertain significance Single submitter
- HTR6 p.Asn44Lys Uncertain significance Single submitter
- HTR6 p.Asp123Asn Uncertain significance Single submitter
- HTR6 p.Cys118Tyr Uncertain significance Single submitter
- HTR6 p.Cys311Ser Uncertain significance Single submitter
- HTR6 p.Cys34Ser Uncertain significance Single submitter
- HTR6 p.Gln345His Uncertain significance Single submitter
- HTR6 p.Glu168Lys Uncertain significance Single submitter
- HTR6 p.Gly16Glu Uncertain significance Single submitter
- HTR6 p.Gly202Val Uncertain significance Single submitter
- HTR6 p.Gly388Cys Uncertain significance Single submitter
- HTR6 p.Gly388Ser Uncertain significance Single submitter
- HTR6 p.Ile204Val Uncertain significance Single submitter
- HTR6 p.Ile423Val Uncertain significance Single submitter
- HTR6 p.Ile48Phe Uncertain significance Single submitter
- HTR6 p.Leu146Pro Uncertain significance Single submitter
- HTR6 p.Leu162Val Uncertain significance Single submitter
- HTR6 p.Leu169Pro Uncertain significance Single submitter
- HTR6 p.Leu255Pro Uncertain significance Single submitter
- HTR6 p.Leu46Val Uncertain significance Single submitter
- HTR6 p.Leu47Pro Uncertain significance Single submitter
- HTR6 p.Met315Arg Uncertain significance Single submitter
- HTR6 p.Phe284Tyr Uncertain significance Single submitter
- HTR6 p.Pro161Ser Uncertain significance Single submitter
- HTR6 p.Pro19Leu Uncertain significance Single submitter
- HTR6 p.Pro23Arg Uncertain significance Single submitter
- HTR6 p.Pro240Ser Uncertain significance Single submitter
- HTR6 p.Pro245Ser Uncertain significance Single submitter
- HTR6 p.Pro371Leu Uncertain significance Single submitter
- HTR6 p.Pro375Leu Uncertain significance Single submitter
- HTR6 p.Pro409Leu Uncertain significance Single submitter
- HTR6 p.Pro434Leu Uncertain significance Single submitter
- HTR6 p.Pro55Thr Uncertain significance Single submitter
- HTR6 p.Pro81Leu Uncertain significance Single submitter
- HTR6 p.Ser130Trp Uncertain significance Single submitter
- HTR6 p.Ser380Leu Uncertain significance Single submitter
- HTR6 p.Ser390Ala Uncertain significance Single submitter
- HTR6 p.Thr236Arg Uncertain significance Single submitter
- HTR6 p.Thr257Met Uncertain significance Single submitter
- HTR6 p.Thr314Asn Uncertain significance Single submitter
- HTR6 p.Thr355Ile Uncertain significance Single submitter
- HTR6 p.Thr395Met Uncertain significance Single submitter
- HTR6 p.Thr8Ile Uncertain significance Single submitter
- HTR6 p.Trp15Cys Uncertain significance Single submitter
- HTR6 p.Tyr89Cys Uncertain significance Single submitter
- HTR6 p.Tyr89His Uncertain significance Single submitter
- HTR6 p.Val220Met Uncertain significance Single submitter
- HTR6 p.Val290Ile Uncertain significance Single submitter
- HTR6 p.Val293Met Uncertain significance Single submitter
- HTR6 p.Val35Gly Uncertain significance Single submitter
- HTR6 p.Val36Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- HTR6 p.Arg261Ser Uncertain significance Single submitter
- HTR6 p.Arg325Trp Uncertain significance Single submitter
- HTR6 p.Arg91Cys Uncertain significance Single submitter
- HTR6 p.Asp106Gly Uncertain significance Single submitter
- HTR6 p.Leu156Phe Uncertain significance Single submitter
- HTR6 p.Met74Ile Uncertain significance Single submitter
All HTR6 variants
Benign 6
Likely benign 8
- p.Ala384Ser Single submitter
- p.Ala415Thr Single submitter
- p.Ala426= Single submitter
- p.Arg342Trp Single submitter
- p.Asp424Asn Single submitter
- p.Glu429Lys Single submitter
- p.Leu274= Single submitter
- p.Thr439Met Single submitter
Uncertain significance 72
- p.Ala112Thr Single submitter ⚠
- p.Ala30Glu Single submitter
- p.Ala415Ser Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Ala87Val Single submitter ⚠
- p.Ala95Val Single submitter ⚠
- p.Arg181Gly Single submitter ⚠
- p.Arg244His Single submitter ⚠
- p.Arg254Cys Single submitter ⚠
- p.Arg261Ser Single submitter ⚠
- p.Arg261Thr Single submitter ⚠
- p.Arg325Trp Single submitter ⚠
- p.Arg339Cys Single submitter ⚠
- p.Arg342Gln Single submitter ⚠
- p.Arg342Leu Single submitter ⚠
- p.Arg354Cys Single submitter ⚠
- p.Arg354His Single submitter ⚠
- p.Arg393Leu Single submitter ⚠
- p.Arg91Cys Single submitter ⚠
- p.Asn44Lys Single submitter ⚠
- p.Asp106Gly Single submitter ⚠
- p.Asp123Asn Single submitter ⚠
- p.Cys118Tyr Single submitter ⚠
- p.Cys311Ser Single submitter ⚠
- p.Cys34Ser Single submitter ⚠
- p.Gln345His Single submitter ⚠
- p.Glu168Lys Single submitter ⚠
- p.Gly16Glu Single submitter ⚠
- p.Gly202Val Single submitter ⚠
- p.Gly388Cys Single submitter ⚠
- p.Gly388Ser Single submitter ⚠
- p.Ile204Val Single submitter ⚠
- p.Ile423Val Single submitter ⚠
- p.Ile48Phe Single submitter ⚠
- p.Leu146Pro Single submitter ⚠
- p.Leu156Phe Single submitter ⚠
- p.Leu162Val Single submitter ⚠
- p.Leu169Pro Single submitter ⚠
- p.Leu255Pro Single submitter ⚠
- p.Leu46Val Single submitter ⚠
- p.Leu47Pro Single submitter ⚠
- p.Met315Arg Single submitter ⚠
- p.Met74Ile Single submitter ⚠
- p.Phe284Tyr Single submitter ⚠
- p.Pro161Ser Single submitter ⚠
- p.Pro19Leu Single submitter ⚠
- p.Pro23Arg Single submitter ⚠
- p.Pro240Ser Single submitter ⚠
- p.Pro245Ser Single submitter ⚠
- p.Pro371Leu Single submitter ⚠
- p.Pro375Leu Single submitter ⚠
- p.Pro409Leu Single submitter ⚠
- p.Pro434Leu Single submitter ⚠
- p.Pro55Thr Single submitter ⚠
- p.Pro81Leu Single submitter ⚠
- p.Ser130Trp Single submitter ⚠
- p.Ser380Leu Single submitter ⚠
- p.Ser390Ala Single submitter ⚠
- p.Thr236Arg Single submitter ⚠
- p.Thr257Met Single submitter ⚠
- p.Thr314Asn Single submitter ⚠
- p.Thr355Ile Single submitter ⚠
- p.Thr395Met Single submitter ⚠
- p.Thr8Ile Single submitter ⚠
- p.Trp15Cys Single submitter ⚠
- p.Tyr89Cys Single submitter ⚠
- p.Tyr89His Single submitter ⚠
- p.Val220Met Single submitter ⚠
- p.Val290Ile Single submitter ⚠
- p.Val293Met Single submitter ⚠
- p.Val35Gly Single submitter ⚠
- p.Val36Ala Single submitter ⚠