HTRA3 — 79 ClinVar variants
All ClinVar germline HTRA3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
1 Benign · 2 Likely benign · 76 Uncertain significance
Full HTRA3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HTRA3 p.Ala331Val Uncertain significance Single submitter
- HTRA3 p.Arg137His Uncertain significance Single submitter
- HTRA3 p.Arg168His Uncertain significance Single submitter
- HTRA3 p.Arg279Gln Uncertain significance Single submitter
- HTRA3 p.Arg355His Uncertain significance Single submitter
- HTRA3 p.Arg360Trp Uncertain significance Single submitter
- HTRA3 p.Arg362Gln Uncertain significance Single submitter
- HTRA3 p.Arg362Trp Uncertain significance Single submitter
- HTRA3 p.Arg38Leu Uncertain significance Single submitter
- HTRA3 p.Arg438Gln Uncertain significance Single submitter
- HTRA3 p.Asn196Asp Uncertain significance Single submitter
- HTRA3 p.Cys83Tyr Uncertain significance Single submitter
- HTRA3 p.Gln204Leu Uncertain significance Single submitter
- HTRA3 p.Glu424Gln Uncertain significance Single submitter
- HTRA3 p.Gly175Ser Uncertain significance Single submitter
- HTRA3 p.Gly184Asp Uncertain significance Single submitter
- HTRA3 p.Gly245Arg Uncertain significance Single submitter
- HTRA3 p.Gly260Ser Uncertain significance Single submitter
- HTRA3 p.Gly358Ser Uncertain significance Single submitter
- HTRA3 p.Gly71Cys Uncertain significance Single submitter
- HTRA3 p.Ile150Asn Uncertain significance Single submitter
- HTRA3 p.Ile179Val Uncertain significance Single submitter
- HTRA3 p.Ile222Val Uncertain significance Single submitter
- HTRA3 p.Ile328Thr Uncertain significance Single submitter
- HTRA3 p.Ile402Met Uncertain significance Single submitter
- HTRA3 p.Leu432Arg Uncertain significance Single submitter
- HTRA3 p.Lys354Arg Uncertain significance Single submitter
- HTRA3 p.Ser420Thr Uncertain significance Single submitter
- HTRA3 p.Tyr293Cys Uncertain significance Single submitter
- HTRA3 p.Val170Met Uncertain significance Single submitter
- HTRA3 p.Val409Ile Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- HTRA3 p.Ala10Pro Uncertain significance Single submitter
- HTRA3 p.Ala27Ser Uncertain significance Single submitter
- HTRA3 p.Ala392Pro Uncertain significance Single submitter
- HTRA3 p.Ala448Pro Uncertain significance Single submitter
- HTRA3 p.Ala88Thr Uncertain significance Single submitter
- HTRA3 p.Arg109His Uncertain significance Single submitter
- HTRA3 p.Arg119His Uncertain significance Single submitter
- HTRA3 p.Arg251Gln Uncertain significance Single submitter
- HTRA3 p.Arg287Gln Uncertain significance Single submitter
- HTRA3 p.Arg339Gln Uncertain significance Single submitter
- HTRA3 p.Arg339Trp Uncertain significance Single submitter
- HTRA3 p.Arg355Cys Uncertain significance Single submitter
- HTRA3 p.Arg437Gln Uncertain significance Single submitter
- HTRA3 p.Arg437Trp Uncertain significance Single submitter
- HTRA3 p.Asn189Ser Uncertain significance Single submitter
- HTRA3 p.Asp213Tyr Uncertain significance Single submitter
- HTRA3 p.Asp290Asn Uncertain significance Single submitter
- HTRA3 p.Asp442Tyr Uncertain significance Single submitter
- HTRA3 p.Glu429Ala Uncertain significance Single submitter
- HTRA3 p.Glu58Ala Uncertain significance Single submitter
- HTRA3 p.Gly115Arg Uncertain significance Single submitter
- HTRA3 p.Gly405Ala Uncertain significance Single submitter
- HTRA3 p.Gly41Ser Uncertain significance Single submitter
- HTRA3 p.Gly42Ser Uncertain significance Single submitter
- HTRA3 p.Gly42Val Uncertain significance Single submitter
- HTRA3 p.Gly63Ser Uncertain significance Single submitter
- HTRA3 p.Ile179Met Uncertain significance Single submitter
- HTRA3 p.Ile231Val Uncertain significance Single submitter
- HTRA3 p.Leu121Met Uncertain significance Single submitter
- HTRA3 p.Leu286Ile Uncertain significance Single submitter
- HTRA3 p.Lys238Asn Uncertain significance Single submitter
- HTRA3 p.Pro164Leu Uncertain significance Single submitter
- HTRA3 p.Pro35Arg Uncertain significance Single submitter
- HTRA3 p.Pro377Arg Uncertain significance Single submitter
- HTRA3 p.Pro377Leu Uncertain significance Single submitter
- HTRA3 p.Pro380Leu Uncertain significance Single submitter
- HTRA3 p.Pro393Gln Uncertain significance Single submitter
- HTRA3 p.Ser195Arg Uncertain significance Single submitter
- HTRA3 p.Ser214Ala Uncertain significance Single submitter
- HTRA3 p.Ser289Cys Uncertain significance Single submitter
- HTRA3 p.Ser32Leu Uncertain significance Single submitter
- HTRA3 p.Thr271Met Uncertain significance Single submitter
- HTRA3 p.Thr325Met Uncertain significance Single submitter
- HTRA3 p.Thr428Pro Uncertain significance Single submitter
- HTRA3 p.Val89Met Uncertain significance Single submitter
All HTRA3 variants
Benign 1
- p.Val269Met Single submitter
Likely benign 2
- p.Ala199= Single submitter
- p.Ala392Val Single submitter
Uncertain significance 76
- p.Ala10Pro Single submitter ⚠
- p.Ala27Ser Single submitter ⚠
- p.Ala331Val Single submitter ⚠
- p.Ala392Pro Single submitter ⚠
- p.Ala448Pro Single submitter ⚠
- p.Ala88Thr Single submitter ⚠
- p.Arg109His Single submitter ⚠
- p.Arg119His Single submitter ⚠
- p.Arg137His Single submitter ⚠
- p.Arg168His Single submitter ⚠
- p.Arg251Gln Single submitter ⚠
- p.Arg279Gln Single submitter ⚠
- p.Arg287Gln Single submitter ⚠
- p.Arg339Gln Single submitter ⚠
- p.Arg339Trp Single submitter ⚠
- p.Arg355Cys Single submitter ⚠
- p.Arg355His Single submitter ⚠
- p.Arg360Trp Single submitter ⚠
- p.Arg362Gln Single submitter ⚠
- p.Arg362Trp Single submitter ⚠
- p.Arg38Leu Single submitter ⚠
- p.Arg437Gln Single submitter ⚠
- p.Arg437Trp Single submitter ⚠
- p.Arg438Gln Single submitter ⚠
- p.Asn189Ser Single submitter ⚠
- p.Asn196Asp Single submitter ⚠
- p.Asp213Tyr Single submitter ⚠
- p.Asp290Asn Single submitter ⚠
- p.Asp442Tyr Single submitter ⚠
- p.Cys83Tyr Single submitter ⚠
- p.Gln204Leu Single submitter ⚠
- p.Glu424Gln Single submitter ⚠
- p.Glu429Ala Single submitter ⚠
- p.Glu58Ala Single submitter ⚠
- p.Gly115Arg Single submitter ⚠
- p.Gly175Ser Single submitter ⚠
- p.Gly184Asp Single submitter ⚠
- p.Gly245Arg Single submitter ⚠
- p.Gly260Ser Single submitter ⚠
- p.Gly358Ser Single submitter ⚠
- p.Gly405Ala Single submitter ⚠
- p.Gly41Ser Single submitter ⚠
- p.Gly42Ser Single submitter ⚠
- p.Gly42Val Single submitter ⚠
- p.Gly63Ser Single submitter ⚠
- p.Gly71Cys Single submitter ⚠
- p.Ile150Asn Single submitter ⚠
- p.Ile179Met Single submitter ⚠
- p.Ile179Val Single submitter ⚠
- p.Ile222Val Single submitter ⚠
- p.Ile231Val Single submitter ⚠
- p.Ile328Thr Single submitter ⚠
- p.Ile402Met Single submitter ⚠
- p.Leu121Met Single submitter ⚠
- p.Leu286Ile Single submitter ⚠
- p.Leu432Arg Single submitter ⚠
- p.Lys238Asn Single submitter ⚠
- p.Lys354Arg Single submitter ⚠
- p.Pro164Leu Single submitter ⚠
- p.Pro35Arg Single submitter ⚠
- p.Pro377Arg Single submitter ⚠
- p.Pro377Leu Single submitter ⚠
- p.Pro380Leu Single submitter ⚠
- p.Pro393Gln Single submitter ⚠
- p.Ser195Arg Single submitter ⚠
- p.Ser214Ala Single submitter ⚠
- p.Ser289Cys Single submitter ⚠
- p.Ser32Leu Single submitter ⚠
- p.Ser420Thr Single submitter ⚠
- p.Thr271Met Single submitter ⚠
- p.Thr325Met Single submitter ⚠
- p.Thr428Pro Single submitter ⚠
- p.Tyr293Cys Single submitter ⚠
- p.Val170Met Single submitter ⚠
- p.Val409Ile Single submitter ⚠
- p.Val89Met Single submitter ⚠