IAPP — 4 ClinVar variants
All ClinVar germline IAPP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 4 flagged for review →
4 Uncertain significance
Full IAPP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 4
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
All IAPP variants
Uncertain significance 4
- p.Arg33Gln Single submitter ⚠
- p.Asn47Ser Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Thr23Ile Single submitter ⚠