ICAM1 — 95 ClinVar variants
All ClinVar germline ICAM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →
1 Conflicting · 8 Benign · 1 Benign/Likely benign · 15 Likely benign · 70 Uncertain significance
Full ICAM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 70
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
ICAM1 p.Arg478Trp
Conflicting
Single submitter
malaria, susceptibility to
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ICAM1 p.Ala167Ser Uncertain significance Single submitter
- ICAM1 p.Ala205Thr Uncertain significance Single submitter
- ICAM1 p.Ala205Val Uncertain significance Single submitter
- ICAM1 p.Ala216Glu Uncertain significance Single submitter
- ICAM1 p.Ala216Thr Uncertain significance Single submitter
- ICAM1 p.Ala280Ser Uncertain significance Single submitter
- ICAM1 p.Ala280Thr Uncertain significance Single submitter
- ICAM1 p.Ala312Val Uncertain significance Single submitter
- ICAM1 p.Ala490Thr Uncertain significance Single submitter
- ICAM1 p.Arg134His Uncertain significance Single submitter
- ICAM1 p.Arg134Ser Uncertain significance Single submitter
- ICAM1 p.Arg143Gln Uncertain significance Single submitter
- ICAM1 p.Arg152Cys Uncertain significance Single submitter
- ICAM1 p.Arg468His Uncertain significance Single submitter
-
ICAM1 p.Arg507Gln
Uncertain significance
Single submitter
malaria, susceptibility to
- ICAM1 p.Arg76Gln Uncertain significance Single submitter
- ICAM1 p.Arg76Leu Uncertain significance Single submitter
- ICAM1 p.Arg7Pro Uncertain significance Single submitter
- ICAM1 p.Asn202Lys Uncertain significance Single submitter
- ICAM1 p.Asn314Ile Uncertain significance Single submitter
- ICAM1 p.Asn314Lys Uncertain significance Single submitter
- ICAM1 p.Asn406Ser Uncertain significance Single submitter
- ICAM1 p.Asn75Ser Uncertain significance Single submitter
- ICAM1 p.Asp399Gly Uncertain significance Single submitter
- ICAM1 p.Asp98His Uncertain significance Single submitter
- ICAM1 p.Cys52Tyr Uncertain significance Single submitter
- ICAM1 p.Gln125Arg Uncertain significance Single submitter
- ICAM1 p.Gln232His Uncertain significance Single submitter
- ICAM1 p.Gln257His Uncertain significance Single submitter
- ICAM1 p.Glu168Ala Uncertain significance Single submitter
- ICAM1 p.Gly139Asp Uncertain significance Single submitter
- ICAM1 p.Gly366Arg Uncertain significance Single submitter
- ICAM1 p.Gly442Arg Uncertain significance Single submitter
- ICAM1 p.His180Arg Uncertain significance Single submitter
- ICAM1 p.His335Arg Uncertain significance Single submitter
- ICAM1 p.Ile484Val Uncertain significance Single submitter
- ICAM1 p.Leu13Phe Uncertain significance Single submitter
- ICAM1 p.Leu17Phe Uncertain significance Single submitter
- ICAM1 p.Leu456Val Uncertain significance Single submitter
- ICAM1 p.Met523Lys Uncertain significance Single submitter
- ICAM1 p.Phe369Ser Uncertain significance Single submitter
- ICAM1 p.Pro477Ser Uncertain significance Single submitter
- ICAM1 p.Pro525Gln Uncertain significance Single submitter
- ICAM1 p.Thr172Met Uncertain significance Single submitter
- ICAM1 p.Thr448Ser Uncertain significance Single submitter
- ICAM1 p.Tyr479His Uncertain significance Single submitter
- ICAM1 p.Val226Leu Uncertain significance Single submitter
- ICAM1 p.Val377Met Uncertain significance Single submitter
- ICAM1 p.Val84Leu Uncertain significance Single submitter
-
ICAM1 p.Arg513Ser
Uncertain significance
No assertion criteria
ICAM1-related disorder
Predictors split 19
The independent predictors disagree with each other — read with care.
- ICAM1 p.Arg134Cys Uncertain significance Single submitter
- ICAM1 p.Arg187Cys Uncertain significance Single submitter
- ICAM1 p.Arg388Trp Uncertain significance Single submitter
-
ICAM1 p.Arg40Trp
Uncertain significance
Single submitter
malaria, susceptibility to
- ICAM1 p.Asp191His Uncertain significance Single submitter
- ICAM1 p.Glu189Lys Uncertain significance Single submitter
- ICAM1 p.Glu324Asp Uncertain significance Single submitter
- ICAM1 p.Glu400Lys Uncertain significance Single submitter
- ICAM1 p.Glu428Gly Uncertain significance Single submitter
- ICAM1 p.Pro219Arg Uncertain significance Single submitter
- ICAM1 p.Pro219Gln Uncertain significance Single submitter
- ICAM1 p.Pro313Ser Uncertain significance Single submitter
- ICAM1 p.Pro313Thr Uncertain significance Single submitter
- ICAM1 p.Thr408Met Uncertain significance Single submitter
- ICAM1 p.Val137Met Uncertain significance Single submitter
- ICAM1 p.Val148Met Uncertain significance Single submitter
- ICAM1 p.Val235Met Uncertain significance Single submitter
- ICAM1 p.Val330Met Likely benign Single submitter
- ICAM1 p.Val44Met Uncertain significance Single submitter
All ICAM1 variants
Conflicting classifications of pathogenicity 1
- p.Arg478Trp Single submitter malaria, susceptibility to ⚠
Benign 8
- p.Arg397Gln Multiple submitters
- p.Asp282= Multiple submitters
- p.Thr408= Multiple submitters
- p.Asn365= Single submitter
- p.Thr279= Single submitter
- c.-9A>C No assertion criteria ICAM1-related disorder
- p.Gly241Arg No assertion criteria ICAM1-related disorder
- p.Lys469Glu No assertion criteria ICAM1-related disorder
Benign/Likely benign 1
- p.Arg458Trp Multiple submitters
Likely benign 15
- p.Thr289= Multiple submitters
- c.1427-6C>T Single submitter
- c.332-4G>A Single submitter
- p.Arg458Gln Single submitter
- p.Arg478Gln Single submitter
- p.Asp240= Single submitter
- p.Asp450Glu Single submitter
- p.Glu428Lys Single submitter
- p.Gly520Glu Single submitter
- p.Ile441= Single submitter
- p.Pro122= Single submitter
- p.Ser49= Single submitter
- p.Val330Met Single submitter ⚠
- p.Gln54= No assertion criteria ICAM1-related disorder
- p.Thr231= No assertion criteria ICAM1-related disorder
Uncertain significance 70
- p.Ala167Ser Single submitter ⚠
- p.Ala205Thr Single submitter ⚠
- p.Ala205Val Single submitter ⚠
- p.Ala216Glu Single submitter ⚠
- p.Ala216Thr Single submitter ⚠
- p.Ala280Ser Single submitter ⚠
- p.Ala280Thr Single submitter ⚠
- p.Ala312Val Single submitter ⚠
- p.Ala490Thr Single submitter ⚠
- p.Arg134Cys Single submitter ⚠
- p.Arg134His Single submitter ⚠
- p.Arg134Ser Single submitter ⚠
- p.Arg143Gln Single submitter ⚠
- p.Arg152Cys Single submitter ⚠
- p.Arg187Cys Single submitter ⚠
- p.Arg388Trp Single submitter ⚠
- p.Arg40Trp Single submitter malaria, susceptibility to ⚠
- p.Arg468His Single submitter ⚠
- p.Arg507Gln Single submitter malaria, susceptibility to ⚠
- p.Arg76Gln Single submitter ⚠
- p.Arg76Leu Single submitter ⚠
- p.Arg7Pro Single submitter ⚠
- p.Asn202Lys Single submitter ⚠
- p.Asn314Ile Single submitter ⚠
- p.Asn314Lys Single submitter ⚠
- p.Asn406Ser Single submitter ⚠
- p.Asn75Ser Single submitter ⚠
- p.Asp191His Single submitter ⚠
- p.Asp399Gly Single submitter ⚠
- p.Asp98His Single submitter ⚠
- p.Cys52Tyr Single submitter ⚠
- p.Gln125Arg Single submitter ⚠
- p.Gln232His Single submitter ⚠
- p.Gln257His Single submitter ⚠
- p.Gln516Ter Single submitter malaria, susceptibility to
- p.Glu168Ala Single submitter ⚠
- p.Glu189Lys Single submitter ⚠
- p.Glu324Asp Single submitter ⚠
- p.Glu400Lys Single submitter ⚠
- p.Glu428Gly Single submitter ⚠
- p.Gly139Asp Single submitter ⚠
- p.Gly366Arg Single submitter ⚠
- p.Gly442Arg Single submitter ⚠
- p.His180Arg Single submitter ⚠
- p.His335Arg Single submitter ⚠
- p.Ile484Val Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu17Phe Single submitter ⚠
- p.Leu456Val Single submitter ⚠
- p.Met523Lys Single submitter ⚠
- p.Phe369Ser Single submitter ⚠
- p.Pro219Arg Single submitter ⚠
- p.Pro219Gln Single submitter ⚠
- p.Pro313Ser Single submitter ⚠
- p.Pro313Thr Single submitter ⚠
- p.Pro404= Single submitter malaria, susceptibility to
- p.Pro477Ser Single submitter ⚠
- p.Pro525Gln Single submitter ⚠
- p.Thr172Met Single submitter ⚠
- p.Thr408Met Single submitter ⚠
- p.Thr448Ser Single submitter ⚠
- p.Tyr479His Single submitter ⚠
- p.Val137Met Single submitter ⚠
- p.Val148Met Single submitter ⚠
- p.Val226Leu Single submitter ⚠
- p.Val235Met Single submitter ⚠
- p.Val377Met Single submitter ⚠
- p.Val44Met Single submitter ⚠
- p.Val84Leu Single submitter ⚠
- p.Arg513Ser No assertion criteria ICAM1-related disorder ⚠